Weight management and determinants of weight change in patients with coronary artery disease

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Weight management and determinants of weight change in patients with coronary artery disease. / Tijssen, Arno; Snaterse, Marjolein ; Minneboo, Madelon et al.

In: Heart, Vol. 107, No. 19, heartjnl-2021-319224, 01.10.2021, p. 1552-1559.

Research output: Contribution to journal › Article › Academic › peer-review

BibTeX

@article{4bba4fdd0eb2493180fc28a8524476f8,

title = "Weight management and determinants of weight change in patients with coronary artery disease",

abstract = "Objective: To study the effects of a comprehensive secondary prevention programme on weight loss and to identify determinants of weight change in patients with coronary artery disease (CAD). Methods: We performed a secondary analysis focusing on the subgroup of overweight CAD patients (BMI ≥27 kg/m2) in the Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists-2 (RESPONSE-2) multicentre randomised trial. We evaluated weight change from baseline to 12-month follow-up; multivariable logistic regression with backward elimination was used to identify determinants of weight change. Results: Intervention patients (n=280) lost significantly more weight than control patients (n=257) (-2.4±7.1 kg vs -0.2±4.6 kg; p<0.001). Individual weight change varied widely, with weight gain (≥1.0 kg) occurring in 36% of interventions versus 41% controls (p=0.21). In the intervention group, weight loss of ≥5% was associated with higher age (OR 2.94), lower educational level (OR 1.91), non-smoking status (OR 2.92), motivation to start with weight loss directly after the baseline visit (OR 2.31) and weight loss programme participation (OR 3.33), whereas weight gain (≥1 kg) was associated with smoking cessation ≤6 months before or during hospitalisation (OR 3.21), non-Caucasian ethnicity (OR 2.77), smoking at baseline (OR 2.70), lower age (<65 years) (OR 1.47) and weight loss programme participation (OR 0.59). Conclusion: The comprehensive secondary prevention programme was, on average, effective in achieving weight loss. However, wide variation was observed. As weight gain was observed in over one in three participants in both groups, prevention of weight gain may be as important as attempts to lose weight. Trial registration number: NTR3937.",

keywords = "coronary artery disease, risk factors",

author = "Arno Tijssen and Marjolein Snaterse and Madelon Minneboo and Sangeeta Lachman and {Scholte op Reimer}, Wilma and Peters, {Ron J.} and J{\o}rstad, {Harald Thune}",

note = "Funding Information: Funding The RESPONSE-2 trial was sponsored by WW International Inc (formerly Weight Watchers International, Inc) (New York, New York, USA), Philips Consumer Lifestyle (Eindhoven, the Netherlands) and an anonymous private fund (Amsterdam, the Netherlands). Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = oct,

day = "1",

doi = "10.1136/heartjnl-2021-319224",

language = "English",

volume = "107",

pages = "1552--1559",

journal = "Heart (British Cardiac Society)",

issn = "1355-6037",

publisher = "BMJ Publishing Group",

number = "19",

}

RIS

TY - JOUR

T1 - Weight management and determinants of weight change in patients with coronary artery disease

AU - Tijssen, Arno

AU - Snaterse, Marjolein

AU - Minneboo, Madelon

AU - Lachman, Sangeeta

AU - Scholte op Reimer, Wilma

AU - Peters, Ron J.

AU - Jørstad, Harald Thune

N1 - Funding Information: Funding The RESPONSE-2 trial was sponsored by WW International Inc (formerly Weight Watchers International, Inc) (New York, New York, USA), Philips Consumer Lifestyle (Eindhoven, the Netherlands) and an anonymous private fund (Amsterdam, the Netherlands). Publisher Copyright: © Author(s) (or their employer(s)) 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Objective: To study the effects of a comprehensive secondary prevention programme on weight loss and to identify determinants of weight change in patients with coronary artery disease (CAD). Methods: We performed a secondary analysis focusing on the subgroup of overweight CAD patients (BMI ≥27 kg/m2) in the Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists-2 (RESPONSE-2) multicentre randomised trial. We evaluated weight change from baseline to 12-month follow-up; multivariable logistic regression with backward elimination was used to identify determinants of weight change. Results: Intervention patients (n=280) lost significantly more weight than control patients (n=257) (-2.4±7.1 kg vs -0.2±4.6 kg; p<0.001). Individual weight change varied widely, with weight gain (≥1.0 kg) occurring in 36% of interventions versus 41% controls (p=0.21). In the intervention group, weight loss of ≥5% was associated with higher age (OR 2.94), lower educational level (OR 1.91), non-smoking status (OR 2.92), motivation to start with weight loss directly after the baseline visit (OR 2.31) and weight loss programme participation (OR 3.33), whereas weight gain (≥1 kg) was associated with smoking cessation ≤6 months before or during hospitalisation (OR 3.21), non-Caucasian ethnicity (OR 2.77), smoking at baseline (OR 2.70), lower age (<65 years) (OR 1.47) and weight loss programme participation (OR 0.59). Conclusion: The comprehensive secondary prevention programme was, on average, effective in achieving weight loss. However, wide variation was observed. As weight gain was observed in over one in three participants in both groups, prevention of weight gain may be as important as attempts to lose weight. Trial registration number: NTR3937.

AB - Objective: To study the effects of a comprehensive secondary prevention programme on weight loss and to identify determinants of weight change in patients with coronary artery disease (CAD). Methods: We performed a secondary analysis focusing on the subgroup of overweight CAD patients (BMI ≥27 kg/m2) in the Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists-2 (RESPONSE-2) multicentre randomised trial. We evaluated weight change from baseline to 12-month follow-up; multivariable logistic regression with backward elimination was used to identify determinants of weight change. Results: Intervention patients (n=280) lost significantly more weight than control patients (n=257) (-2.4±7.1 kg vs -0.2±4.6 kg; p<0.001). Individual weight change varied widely, with weight gain (≥1.0 kg) occurring in 36% of interventions versus 41% controls (p=0.21). In the intervention group, weight loss of ≥5% was associated with higher age (OR 2.94), lower educational level (OR 1.91), non-smoking status (OR 2.92), motivation to start with weight loss directly after the baseline visit (OR 2.31) and weight loss programme participation (OR 3.33), whereas weight gain (≥1 kg) was associated with smoking cessation ≤6 months before or during hospitalisation (OR 3.21), non-Caucasian ethnicity (OR 2.77), smoking at baseline (OR 2.70), lower age (<65 years) (OR 1.47) and weight loss programme participation (OR 0.59). Conclusion: The comprehensive secondary prevention programme was, on average, effective in achieving weight loss. However, wide variation was observed. As weight gain was observed in over one in three participants in both groups, prevention of weight gain may be as important as attempts to lose weight. Trial registration number: NTR3937.

KW - coronary artery disease

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=85111692625&partnerID=8YFLogxK

U2 - 10.1136/heartjnl-2021-319224

DO - 10.1136/heartjnl-2021-319224

M3 - Article

C2 - 34326136

VL - 107

SP - 1552

EP - 1559

JO - Heart (British Cardiac Society)

JF - Heart (British Cardiac Society)

SN - 1355-6037

IS - 19

M1 - heartjnl-2021-319224

ER -

ID: 19262213

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