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The magnitude and directions of the associations between early life factors and metabolic syndrome differ across geographical locations among migrant and non-migrant ghanaians—the rodam study. / van der Heijden, Thijs G. W.; Chilunga, Felix P.; Meeks, Karlijn A. C. et al.

In: International journal of environmental research and public health, Vol. 18, No. 22, 11996, 01.11.2021.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

van der Heijden, TGW, Chilunga, FP, Meeks, KAC, Addo, J, Danquah, I, Beune, EJ, Bahendeka, SK, Klipstein-Grobusch, K, Mockenhaupt, FP, Waltz, MM & Agyemang, C 2021, 'The magnitude and directions of the associations between early life factors and metabolic syndrome differ across geographical locations among migrant and non-migrant ghanaians—the rodam study', International journal of environmental research and public health, vol. 18, no. 22, 11996. https://doi.org/10.3390/ijerph182211996

APA

van der Heijden, T. G. W., Chilunga, F. P., Meeks, K. A. C., Addo, J., Danquah, I., Beune, E. J., Bahendeka, S. K., Klipstein-Grobusch, K., Mockenhaupt, F. P., Waltz, M. M., & Agyemang, C. (2021). The magnitude and directions of the associations between early life factors and metabolic syndrome differ across geographical locations among migrant and non-migrant ghanaians—the rodam study. International journal of environmental research and public health, 18(22), [11996]. https://doi.org/10.3390/ijerph182211996

Vancouver

van der Heijden TGW, Chilunga FP, Meeks KAC, Addo J, Danquah I, Beune EJ et al. The magnitude and directions of the associations between early life factors and metabolic syndrome differ across geographical locations among migrant and non-migrant ghanaians—the rodam study. International journal of environmental research and public health. 2021 Nov 1;18(22):11996. doi: 10.3390/ijerph182211996

Author

BibTeX

@article{1fff1e1fefc3427fa5287fa45b2a4193,
title = "The magnitude and directions of the associations between early life factors and metabolic syndrome differ across geographical locations among migrant and non-migrant ghanaians—the rodam study",
abstract = "Background: Early-life factors (ELFs) such as childhood nutrition and childhood socioeconomic status could be the drivers of the increase in metabolic syndrome (MetSyn) among African populations, but data are lacking. This study evaluated whether markers of childhood nutritional status and childhood socio-economic status were associated with MetSyn in adulthood among migrant Ghanaians living in Europe and non-migrant Ghanaians living in Ghana. Methods: Data from the Research on Obesity and Diabetes among African Migrants (RODAM) study, involving 2008 migrants and 2320 non-migrants aged ≥25 years, were analysed for this study. We used leg-length to height ratio (LHR), which is an anthropometric marker of childhood nutritional status, and parental education, which is a marker of childhood socio-economic status, as proxies. Adjusted odds ratios (AOR) and 95% confidence intervals (95% CI) were calculated by logistic regression with adjustments for demographic and lifestyle factors. Results: Parental education was higher among Ghanaians in Europe than among residents in rural and urban Ghana. The prevalence of MetSyn was 18.5%, 27.7% and 33.5% for rural, urban, and migrant residents, respectively. LHR was inversely associated with MetSyn among migrants. Compared with high paternal education, individuals with low paternal education had lower odds of MetSyn in migrants (AOR 0.71 95% CI 0.54–0.94). In contrast, compared with high maternal education, individuals with intermediate maternal education had higher odds of MetSyn in urban Ghanaians (AOR 4.53 95% CI 1.50–3.74). No associations were found among rural Ghanaians. Conclusion: The magnitude and direction of the associations between ELFs and MetSyn differ across geographical locations. Intermediate maternal education was positively associated with MetSyn among urban Ghanaians, while LHR and low paternal education were inversely associated with MetSyn among migrant Ghanaians. Further research into the interplay of genetics, environment and behaviour is needed to elucidate the underlying pathological mechanisms of MetSyn amongst migrants.",
keywords = "Diabetes, Early life factors, Metabolic syndrome, Migration, Obesity",
author = "{van der Heijden}, {Thijs G. W.} and Chilunga, {Felix P.} and Meeks, {Karlijn A. C.} and Juliet Addo and Ina Danquah and Beune, {Erik J.} and Bahendeka, {Silver K.} and Kerstin Klipstein-Grobusch and Mockenhaupt, {Frank P.} and Waltz, {Mitzi M.} and Charles Agyemang",
note = "Funding Information: Funding: The RODAM study was supported by the European Commission under the Framework Programme (Grant Number: 278901). K.A.C.M. is supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = nov,
day = "1",
doi = "10.3390/ijerph182211996",
language = "English",
volume = "18",
journal = "International journal of environmental research and public health",
issn = "1661-7827",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "22",

}

RIS

TY - JOUR

T1 - The magnitude and directions of the associations between early life factors and metabolic syndrome differ across geographical locations among migrant and non-migrant ghanaians—the rodam study

AU - van der Heijden, Thijs G. W.

AU - Chilunga, Felix P.

AU - Meeks, Karlijn A. C.

AU - Addo, Juliet

AU - Danquah, Ina

AU - Beune, Erik J.

AU - Bahendeka, Silver K.

AU - Klipstein-Grobusch, Kerstin

AU - Mockenhaupt, Frank P.

AU - Waltz, Mitzi M.

AU - Agyemang, Charles

N1 - Funding Information: Funding: The RODAM study was supported by the European Commission under the Framework Programme (Grant Number: 278901). K.A.C.M. is supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Background: Early-life factors (ELFs) such as childhood nutrition and childhood socioeconomic status could be the drivers of the increase in metabolic syndrome (MetSyn) among African populations, but data are lacking. This study evaluated whether markers of childhood nutritional status and childhood socio-economic status were associated with MetSyn in adulthood among migrant Ghanaians living in Europe and non-migrant Ghanaians living in Ghana. Methods: Data from the Research on Obesity and Diabetes among African Migrants (RODAM) study, involving 2008 migrants and 2320 non-migrants aged ≥25 years, were analysed for this study. We used leg-length to height ratio (LHR), which is an anthropometric marker of childhood nutritional status, and parental education, which is a marker of childhood socio-economic status, as proxies. Adjusted odds ratios (AOR) and 95% confidence intervals (95% CI) were calculated by logistic regression with adjustments for demographic and lifestyle factors. Results: Parental education was higher among Ghanaians in Europe than among residents in rural and urban Ghana. The prevalence of MetSyn was 18.5%, 27.7% and 33.5% for rural, urban, and migrant residents, respectively. LHR was inversely associated with MetSyn among migrants. Compared with high paternal education, individuals with low paternal education had lower odds of MetSyn in migrants (AOR 0.71 95% CI 0.54–0.94). In contrast, compared with high maternal education, individuals with intermediate maternal education had higher odds of MetSyn in urban Ghanaians (AOR 4.53 95% CI 1.50–3.74). No associations were found among rural Ghanaians. Conclusion: The magnitude and direction of the associations between ELFs and MetSyn differ across geographical locations. Intermediate maternal education was positively associated with MetSyn among urban Ghanaians, while LHR and low paternal education were inversely associated with MetSyn among migrant Ghanaians. Further research into the interplay of genetics, environment and behaviour is needed to elucidate the underlying pathological mechanisms of MetSyn amongst migrants.

AB - Background: Early-life factors (ELFs) such as childhood nutrition and childhood socioeconomic status could be the drivers of the increase in metabolic syndrome (MetSyn) among African populations, but data are lacking. This study evaluated whether markers of childhood nutritional status and childhood socio-economic status were associated with MetSyn in adulthood among migrant Ghanaians living in Europe and non-migrant Ghanaians living in Ghana. Methods: Data from the Research on Obesity and Diabetes among African Migrants (RODAM) study, involving 2008 migrants and 2320 non-migrants aged ≥25 years, were analysed for this study. We used leg-length to height ratio (LHR), which is an anthropometric marker of childhood nutritional status, and parental education, which is a marker of childhood socio-economic status, as proxies. Adjusted odds ratios (AOR) and 95% confidence intervals (95% CI) were calculated by logistic regression with adjustments for demographic and lifestyle factors. Results: Parental education was higher among Ghanaians in Europe than among residents in rural and urban Ghana. The prevalence of MetSyn was 18.5%, 27.7% and 33.5% for rural, urban, and migrant residents, respectively. LHR was inversely associated with MetSyn among migrants. Compared with high paternal education, individuals with low paternal education had lower odds of MetSyn in migrants (AOR 0.71 95% CI 0.54–0.94). In contrast, compared with high maternal education, individuals with intermediate maternal education had higher odds of MetSyn in urban Ghanaians (AOR 4.53 95% CI 1.50–3.74). No associations were found among rural Ghanaians. Conclusion: The magnitude and direction of the associations between ELFs and MetSyn differ across geographical locations. Intermediate maternal education was positively associated with MetSyn among urban Ghanaians, while LHR and low paternal education were inversely associated with MetSyn among migrant Ghanaians. Further research into the interplay of genetics, environment and behaviour is needed to elucidate the underlying pathological mechanisms of MetSyn amongst migrants.

KW - Diabetes

KW - Early life factors

KW - Metabolic syndrome

KW - Migration

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85118974545&partnerID=8YFLogxK

U2 - 10.3390/ijerph182211996

DO - 10.3390/ijerph182211996

M3 - Article

C2 - 34831754

VL - 18

JO - International journal of environmental research and public health

JF - International journal of environmental research and public health

SN - 1661-7827

IS - 22

M1 - 11996

ER -

ID: 20466155