Research output: Contribution to journal › Article › Academic › peer-review
The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. / Grebely, Jason; Page, Kimberly; Sacks-Davis, Rachel et al.
In: Hepatology (Baltimore, Md.), Vol. 59, No. 1, 2014, p. 109-120.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection
AU - Grebely, Jason
AU - Page, Kimberly
AU - Sacks-Davis, Rachel
AU - van der Loeff, Maarten Schim
AU - Rice, Thomas M.
AU - Bruneau, Julie
AU - Morris, Meghan D.
AU - Hajarizadeh, Behzad
AU - Amin, Janaki
AU - Cox, Andrea L.
AU - Kim, Arthur Y.
AU - McGovern, Barbara H.
AU - Schinkel, Janke
AU - George, Jacob
AU - Shoukry, Naglaa H.
AU - Lauer, Georg M.
AU - Maher, Lisa
AU - Lloyd, Andrew R.
AU - Hellard, Margaret
AU - Dore, Gregory J.
AU - Prins, Maria
AU - AUTHOR GROUP
AU - Lauer, Georg
AU - Morris, Meghan
AU - Hahn, Judy
AU - Rilla, Megan
AU - Alavi, Maryam
AU - Bouchard, Rachel
AU - Evans, Jennifer
AU - Grady, Bart
AU - Aneja, Jasneet
AU - Teutsch, Suzy
AU - White, Bethany
AU - Wells, Brittany
AU - Zang, Geng
AU - Applegate, Tanya
AU - Matthews, Gail
AU - Yeung, Barbara
AU - Prince, Leslie Erin
AU - Roy, Elise
AU - Bates, Anna
AU - Enriquez, Jarliene
AU - Chow, Sammy
AU - McCredie, Luke
AU - Aitken, Campbell
AU - Doyle, Joseph
AU - Spelman, Tim
PY - 2014
Y1 - 2014
N2 - Although 20%-40% of persons with acute hepatitis C virus (HCV) infection demonstrate spontaneous clearance, the time course and factors associated with clearance remain poorly understood. We investigated the time to spontaneous clearance and predictors among participants with acute HCV using Cox proportional hazards analyses. Data for this analysis were drawn from an international collaboration of nine prospective cohorts evaluating outcomes after acute HCV infection. Among 632 participants with acute HCV, 35% were female, 82% were Caucasian, 49% had interleukin-28 (IL28)B CC genotype (rs12979860), 96% had injected drugs ever, 47% were infected with HCV genotype 1, and 7% had human immunodeficiency virus (HIV) coinfection. Twenty-eight percent were HCV antibody negative/RNA positive at the time of acute HCV detection (early acute HCV). During follow-up, spontaneous clearance occurred in 173 of 632, and at 1 year after infection, 25% (95% confidence interval [CI]: 21, 29) had cleared virus. Among those with clearance, the median time to clearance was 16.5 weeks (IQR: 10.5, 33.4), with 34%, 67%, and 83% demonstrating clearance at 3, 6, and 12 months. Adjusting for age, factors independently associated with time to spontaneous clearance included female sex (adjusted hazards ratio [AHR]: 2.16; 95% CI: 1.48, 3.18), IL28B CC genotype (versus CT/TT; AHR, 2.26; 95% CI: 1.52, 3.34), and HCV genotype 1 (versus non-genotype 1; AHR: 1.56; 95% CI: 1.06, 2.30). The effect of IL28B genotype and HCV genotype on spontaneous clearance was greater among females, compared to males. Conclusions: Female sex, favorable IL28B genotype, and HCV genotype 1 are independent predictors of spontaneous clearance. Further research is required to elucidate the observed sex-based differences in HCV control
AB - Although 20%-40% of persons with acute hepatitis C virus (HCV) infection demonstrate spontaneous clearance, the time course and factors associated with clearance remain poorly understood. We investigated the time to spontaneous clearance and predictors among participants with acute HCV using Cox proportional hazards analyses. Data for this analysis were drawn from an international collaboration of nine prospective cohorts evaluating outcomes after acute HCV infection. Among 632 participants with acute HCV, 35% were female, 82% were Caucasian, 49% had interleukin-28 (IL28)B CC genotype (rs12979860), 96% had injected drugs ever, 47% were infected with HCV genotype 1, and 7% had human immunodeficiency virus (HIV) coinfection. Twenty-eight percent were HCV antibody negative/RNA positive at the time of acute HCV detection (early acute HCV). During follow-up, spontaneous clearance occurred in 173 of 632, and at 1 year after infection, 25% (95% confidence interval [CI]: 21, 29) had cleared virus. Among those with clearance, the median time to clearance was 16.5 weeks (IQR: 10.5, 33.4), with 34%, 67%, and 83% demonstrating clearance at 3, 6, and 12 months. Adjusting for age, factors independently associated with time to spontaneous clearance included female sex (adjusted hazards ratio [AHR]: 2.16; 95% CI: 1.48, 3.18), IL28B CC genotype (versus CT/TT; AHR, 2.26; 95% CI: 1.52, 3.34), and HCV genotype 1 (versus non-genotype 1; AHR: 1.56; 95% CI: 1.06, 2.30). The effect of IL28B genotype and HCV genotype on spontaneous clearance was greater among females, compared to males. Conclusions: Female sex, favorable IL28B genotype, and HCV genotype 1 are independent predictors of spontaneous clearance. Further research is required to elucidate the observed sex-based differences in HCV control
U2 - 10.1002/hep.26639
DO - 10.1002/hep.26639
M3 - Article
C2 - 23908124
VL - 59
SP - 109
EP - 120
JO - Hepatology (Baltimore, Md.)
JF - Hepatology (Baltimore, Md.)
SN - 0270-9139
IS - 1
ER -
ID: 2186581