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The association between maternal stress and glucocorticoid rhythmicity in human milk. / Romijn, Michelle; van Tilburg, Luca J. L.; Hollanders, Jonneke J. et al.

In: Nutrients, Vol. 13, No. 5, 1608, 01.05.2021.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Romijn, M, van Tilburg, LJL, Hollanders, JJ, van der Voorn, B, de Goede, P, Dolman, KM, Heijboer, AC, Broekman, BFP, Rotteveel, J & Finken, MJJ 2021, 'The association between maternal stress and glucocorticoid rhythmicity in human milk', Nutrients, vol. 13, no. 5, 1608. https://doi.org/10.3390/nu13051608

APA

Romijn, M., van Tilburg, L. J. L., Hollanders, J. J., van der Voorn, B., de Goede, P., Dolman, K. M., Heijboer, A. C., Broekman, B. F. P., Rotteveel, J., & Finken, M. J. J. (2021). The association between maternal stress and glucocorticoid rhythmicity in human milk. Nutrients, 13(5), [1608]. https://doi.org/10.3390/nu13051608

Vancouver

Romijn M, van Tilburg LJL, Hollanders JJ, van der Voorn B, de Goede P, Dolman KM et al. The association between maternal stress and glucocorticoid rhythmicity in human milk. Nutrients. 2021 May 1;13(5):1608. doi: 10.3390/nu13051608

Author

Romijn, Michelle ; van Tilburg, Luca J. L. ; Hollanders, Jonneke J. et al. / The association between maternal stress and glucocorticoid rhythmicity in human milk. In: Nutrients. 2021 ; Vol. 13, No. 5.

BibTeX

@article{44951c0671f54cfeade9d4b185d6d486,
title = "The association between maternal stress and glucocorticoid rhythmicity in human milk",
abstract = "Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Methods: We included 19 mothers who sought consultation at the psychiatry–obstetric–pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography–tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software. Results: For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group (p = 0.02). GC levels in human milk and saliva were highly correlated within each group (p < 0.001). Conclusion: Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs.",
keywords = "Breast milk, Glucocorticoid rhythm, Hypothalamus–pituitary–adrenal axis, Psychopathology",
author = "Michelle Romijn and {van Tilburg}, {Luca J. L.} and Hollanders, {Jonneke J.} and {van der Voorn}, Bibian and {de Goede}, Paul and Dolman, {Koert M.} and Heijboer, {Annemieke C.} and Broekman, {Birit F. P.} and Joost Rotteveel and Finken, {Martijn J. J.}",
note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = may,
day = "1",
doi = "10.3390/nu13051608",
language = "English",
volume = "13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "5",

}

RIS

TY - JOUR

T1 - The association between maternal stress and glucocorticoid rhythmicity in human milk

AU - Romijn, Michelle

AU - van Tilburg, Luca J. L.

AU - Hollanders, Jonneke J.

AU - van der Voorn, Bibian

AU - de Goede, Paul

AU - Dolman, Koert M.

AU - Heijboer, Annemieke C.

AU - Broekman, Birit F. P.

AU - Rotteveel, Joost

AU - Finken, Martijn J. J.

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Methods: We included 19 mothers who sought consultation at the psychiatry–obstetric–pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography–tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software. Results: For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group (p = 0.02). GC levels in human milk and saliva were highly correlated within each group (p < 0.001). Conclusion: Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs.

AB - Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on the diurnal rhythmicity of breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant women with an increased risk of psychological distress with control mothers for GC diurnal rhythmicity in milk and saliva obtained at the same time. Methods: We included 19 mothers who sought consultation at the psychiatry–obstetric–pediatric (POP) outpatient clinic and 44 control mothers. One month postpartum, mothers collected on average eight paired milk and saliva samples during a 24 h period. GC levels were measured using liquid chromatography–tandem mass spectrometry. GC rhythmicity parameters were determined with specialized software. Results: For both milk and saliva, no group differences regarding GC rhythms were found. Milk cortisol area under the curve with respect to the ground was lower in the POP group than in the control group (p = 0.02). GC levels in human milk and saliva were highly correlated within each group (p < 0.001). Conclusion: Although there were no differences between groups in GC rhythmicity, the total amount of milk cortisol was lower in the POP group. Long-term follow-up is needed to address the impact of vertical transmission of breast milk GCs.

KW - Breast milk

KW - Glucocorticoid rhythm

KW - Hypothalamus–pituitary–adrenal axis

KW - Psychopathology

UR - http://www.scopus.com/inward/record.url?scp=85105921188&partnerID=8YFLogxK

U2 - 10.3390/nu13051608

DO - 10.3390/nu13051608

M3 - Article

C2 - 34064929

VL - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 5

M1 - 1608

ER -

ID: 18312488