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Targeting working memory to modify emotional reactivity in adult attention deficit hyperactivity disorder: a functional magnetic resonance imaging study. / Kaiser, Antonia; Reneman, Liesbeth; Lucassen, Paul J. et al.

In: Brain imaging and behavior, 2021.

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@article{0f335c22728a441f92ffd9be79d1e1f3,
title = "Targeting working memory to modify emotional reactivity in adult attention deficit hyperactivity disorder: a functional magnetic resonance imaging study",
abstract = "Understanding the neural mechanisms of emotional reactivity in Attention-Deficit/Hyperactivity Disorder (ADHD) may help develop more effective treatments that target emotion dysregulation. In adult ADHD, emotion regulation problems cover a range of dimensions, including emotional reactivity (ER). One important process that could underlie an impaired ER in ADHD might be impaired working memory (WM) processing. We recently demonstrated that taxing WM prior to the exposure of emotionally salient stimuli reduced physiological and subjective reactivity to such cues in heavy drinkers, suggesting lasting effects of WM activation on ER. Here, we investigated neural mechanisms that could underlie the interaction between WM and ER in adult ADHD participants. We included 30 male ADHD participants and 30 matched controls. Participants performed a novel functional magnetic resonance imaging paradigm in which active WM-blocks were alternated with passive blocks of negative and neutral images. We demonstrated group-independent significant main effects of negative emotional images on amygdala activation, and WM-load on paracingulate gyrus and dorsolateral prefrontal cortex activation. Contrary to earlier reports in adolescent ADHD, no impairments were found in neural correlates of WM or ER. Moreover, taxing WM did not alter the neural correlates of ER in either ADHD or control participants. While we did find effects on the amygdala, paCG, and dlPFC activation, we did not find interactions between WM and ER, possibly due to the relatively unimpaired ADHD population and a well-matched control group. Whether targeting WM might be effective in participants with ADHD with severe ER impairments remains to be investigated.",
keywords = "Adult Attention-Deficit/Hyperactivity Disorder (ADHD), Emotional dysregulation, Emotional reactivity, Functional magnetic resonance imaging (fMRI), Working memory",
author = "Antonia Kaiser and Liesbeth Reneman and Lucassen, {Paul J.} and {de Vries}, {Taco J.} and Anouk Schrantee and Kaag, {Anne Marije}",
note = "Funding Information: This work was supported by Amsterdam Neuroscience [to A.M.K., A.S., P.J.L., T.J.dV., and L.R.], Amsterdam Brain & Cognition [to A.S., P.J.L., and L.R.] and Urban Mental Health Amsterdam [to P.J.L, A.S.]. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
doi = "10.1007/s11682-021-00532-6",
language = "English",
journal = "Brain imaging and behavior",
issn = "1931-7557",
publisher = "Springer New York",

}

RIS

TY - JOUR

T1 - Targeting working memory to modify emotional reactivity in adult attention deficit hyperactivity disorder: a functional magnetic resonance imaging study

AU - Kaiser, Antonia

AU - Reneman, Liesbeth

AU - Lucassen, Paul J.

AU - de Vries, Taco J.

AU - Schrantee, Anouk

AU - Kaag, Anne Marije

N1 - Funding Information: This work was supported by Amsterdam Neuroscience [to A.M.K., A.S., P.J.L., T.J.dV., and L.R.], Amsterdam Brain & Cognition [to A.S., P.J.L., and L.R.] and Urban Mental Health Amsterdam [to P.J.L, A.S.]. Publisher Copyright: © 2021, The Author(s).

PY - 2021

Y1 - 2021

N2 - Understanding the neural mechanisms of emotional reactivity in Attention-Deficit/Hyperactivity Disorder (ADHD) may help develop more effective treatments that target emotion dysregulation. In adult ADHD, emotion regulation problems cover a range of dimensions, including emotional reactivity (ER). One important process that could underlie an impaired ER in ADHD might be impaired working memory (WM) processing. We recently demonstrated that taxing WM prior to the exposure of emotionally salient stimuli reduced physiological and subjective reactivity to such cues in heavy drinkers, suggesting lasting effects of WM activation on ER. Here, we investigated neural mechanisms that could underlie the interaction between WM and ER in adult ADHD participants. We included 30 male ADHD participants and 30 matched controls. Participants performed a novel functional magnetic resonance imaging paradigm in which active WM-blocks were alternated with passive blocks of negative and neutral images. We demonstrated group-independent significant main effects of negative emotional images on amygdala activation, and WM-load on paracingulate gyrus and dorsolateral prefrontal cortex activation. Contrary to earlier reports in adolescent ADHD, no impairments were found in neural correlates of WM or ER. Moreover, taxing WM did not alter the neural correlates of ER in either ADHD or control participants. While we did find effects on the amygdala, paCG, and dlPFC activation, we did not find interactions between WM and ER, possibly due to the relatively unimpaired ADHD population and a well-matched control group. Whether targeting WM might be effective in participants with ADHD with severe ER impairments remains to be investigated.

AB - Understanding the neural mechanisms of emotional reactivity in Attention-Deficit/Hyperactivity Disorder (ADHD) may help develop more effective treatments that target emotion dysregulation. In adult ADHD, emotion regulation problems cover a range of dimensions, including emotional reactivity (ER). One important process that could underlie an impaired ER in ADHD might be impaired working memory (WM) processing. We recently demonstrated that taxing WM prior to the exposure of emotionally salient stimuli reduced physiological and subjective reactivity to such cues in heavy drinkers, suggesting lasting effects of WM activation on ER. Here, we investigated neural mechanisms that could underlie the interaction between WM and ER in adult ADHD participants. We included 30 male ADHD participants and 30 matched controls. Participants performed a novel functional magnetic resonance imaging paradigm in which active WM-blocks were alternated with passive blocks of negative and neutral images. We demonstrated group-independent significant main effects of negative emotional images on amygdala activation, and WM-load on paracingulate gyrus and dorsolateral prefrontal cortex activation. Contrary to earlier reports in adolescent ADHD, no impairments were found in neural correlates of WM or ER. Moreover, taxing WM did not alter the neural correlates of ER in either ADHD or control participants. While we did find effects on the amygdala, paCG, and dlPFC activation, we did not find interactions between WM and ER, possibly due to the relatively unimpaired ADHD population and a well-matched control group. Whether targeting WM might be effective in participants with ADHD with severe ER impairments remains to be investigated.

KW - Adult Attention-Deficit/Hyperactivity Disorder (ADHD)

KW - Emotional dysregulation

KW - Emotional reactivity

KW - Functional magnetic resonance imaging (fMRI)

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=85115028092&partnerID=8YFLogxK

U2 - 10.1007/s11682-021-00532-6

DO - 10.1007/s11682-021-00532-6

M3 - Article

C2 - 34524649

JO - Brain imaging and behavior

JF - Brain imaging and behavior

SN - 1931-7557

ER -

ID: 19814955