Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies

Standard

Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies. / Hassani Lahsinoui, H.; Amraoui, F.; Spijkers, L. J.A. et al.

In: Scientific reports, Vol. 11, No. 1, 4387, 23.02.2021.

Research output: Contribution to journal › Article › Academic › peer-review

BibTeX

@article{d0591adbef6f4a979d6e35b9bdd94078,

title = "Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies",

abstract = "Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in human samples. While soluble syndecan-1 and heparan sulphate were similar in plasma of preeclamptic and normotensive pregnant women, dermatan sulphate was increased and keratan sulphate decreased in preeclamptic women. Dermatan sulphate was correlated with soluble syndecan-1, and inversely correlated with blood pressure and activated partial thromboplastin time. To determine if syndecan-1 was a prerequisite for the sFlt1 induced increase in blood pressure in mice we studied the effect of sFlt1 on blood pressure and vascular contractile responses in syndecan-1 deficient and wild type male mice. The classical sFlt1 induced rise in blood pressure was absent in syndecan-1 deficient mice indicating that syndecan-1 is a prerequisite for sFlt1 induced increase in blood pressure central to preeclampsia. The results show that an interplay between syndecan-1 and dermatan sulphate contributes to sFlt1 induced blood pressure elevation in pre-eclampsia.",

author = "{Hassani Lahsinoui}, H. and F. Amraoui and Spijkers, {L. J.A.} and Veenboer, {G. J.M.} and Peters, {S. L.M.} and {van Vlies}, N. and L. Vogt and C. Ris-Stalpers and {van den Born}, {B. J.H.} and Afink, {G. B.}",

note = "Funding Information: This study was funded by a Clinical Fellowship awarded to B.J.H. van den Born (90700310) from the Netherlands Organization for Scientific Research/ZonMw, The Netherlands. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Data from this study has been previously published in the PhD thesis of F.A34. Figures and tables from this work have been adapted with permission of F.A. and the University of Amsterdam. Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = feb,

day = "23",

doi = "10.1038/s41598-021-82972-0",

language = "English",

volume = "11",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

RIS

TY - JOUR

T1 - Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies

AU - Hassani Lahsinoui, H.

AU - Amraoui, F.

AU - Spijkers, L. J.A.

AU - Veenboer, G. J.M.

AU - Peters, S. L.M.

AU - van Vlies, N.

AU - Vogt, L.

AU - Ris-Stalpers, C.

AU - van den Born, B. J.H.

AU - Afink, G. B.

N1 - Funding Information: This study was funded by a Clinical Fellowship awarded to B.J.H. van den Born (90700310) from the Netherlands Organization for Scientific Research/ZonMw, The Netherlands. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Data from this study has been previously published in the PhD thesis of F.A34. Figures and tables from this work have been adapted with permission of F.A. and the University of Amsterdam. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2/23

Y1 - 2021/2/23

N2 - Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in human samples. While soluble syndecan-1 and heparan sulphate were similar in plasma of preeclamptic and normotensive pregnant women, dermatan sulphate was increased and keratan sulphate decreased in preeclamptic women. Dermatan sulphate was correlated with soluble syndecan-1, and inversely correlated with blood pressure and activated partial thromboplastin time. To determine if syndecan-1 was a prerequisite for the sFlt1 induced increase in blood pressure in mice we studied the effect of sFlt1 on blood pressure and vascular contractile responses in syndecan-1 deficient and wild type male mice. The classical sFlt1 induced rise in blood pressure was absent in syndecan-1 deficient mice indicating that syndecan-1 is a prerequisite for sFlt1 induced increase in blood pressure central to preeclampsia. The results show that an interplay between syndecan-1 and dermatan sulphate contributes to sFlt1 induced blood pressure elevation in pre-eclampsia.

AB - Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in human samples. While soluble syndecan-1 and heparan sulphate were similar in plasma of preeclamptic and normotensive pregnant women, dermatan sulphate was increased and keratan sulphate decreased in preeclamptic women. Dermatan sulphate was correlated with soluble syndecan-1, and inversely correlated with blood pressure and activated partial thromboplastin time. To determine if syndecan-1 was a prerequisite for the sFlt1 induced increase in blood pressure in mice we studied the effect of sFlt1 on blood pressure and vascular contractile responses in syndecan-1 deficient and wild type male mice. The classical sFlt1 induced rise in blood pressure was absent in syndecan-1 deficient mice indicating that syndecan-1 is a prerequisite for sFlt1 induced increase in blood pressure central to preeclampsia. The results show that an interplay between syndecan-1 and dermatan sulphate contributes to sFlt1 induced blood pressure elevation in pre-eclampsia.

UR - http://www.scopus.com/inward/record.url?scp=85101527942&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-82972-0

DO - 10.1038/s41598-021-82972-0

M3 - Article

C2 - 33623064

AN - SCOPUS:85101527942

VL - 11

JO - Scientific reports

JF - Scientific reports

SN - 2045-2322

IS - 1

M1 - 4387

ER -

ID: 17474311

Generic Portal