Research output: Contribution to journal › Article › Academic › peer-review
Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies. / Hassani Lahsinoui, H.; Amraoui, F.; Spijkers, L. J.A. et al.
In: Scientific reports, Vol. 11, No. 1, 4387, 23.02.2021.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies
AU - Hassani Lahsinoui, H.
AU - Amraoui, F.
AU - Spijkers, L. J.A.
AU - Veenboer, G. J.M.
AU - Peters, S. L.M.
AU - van Vlies, N.
AU - Vogt, L.
AU - Ris-Stalpers, C.
AU - van den Born, B. J.H.
AU - Afink, G. B.
N1 - Funding Information: This study was funded by a Clinical Fellowship awarded to B.J.H. van den Born (90700310) from the Netherlands Organization for Scientific Research/ZonMw, The Netherlands. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Data from this study has been previously published in the PhD thesis of F.A34. Figures and tables from this work have been adapted with permission of F.A. and the University of Amsterdam. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2/23
Y1 - 2021/2/23
N2 - Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in human samples. While soluble syndecan-1 and heparan sulphate were similar in plasma of preeclamptic and normotensive pregnant women, dermatan sulphate was increased and keratan sulphate decreased in preeclamptic women. Dermatan sulphate was correlated with soluble syndecan-1, and inversely correlated with blood pressure and activated partial thromboplastin time. To determine if syndecan-1 was a prerequisite for the sFlt1 induced increase in blood pressure in mice we studied the effect of sFlt1 on blood pressure and vascular contractile responses in syndecan-1 deficient and wild type male mice. The classical sFlt1 induced rise in blood pressure was absent in syndecan-1 deficient mice indicating that syndecan-1 is a prerequisite for sFlt1 induced increase in blood pressure central to preeclampsia. The results show that an interplay between syndecan-1 and dermatan sulphate contributes to sFlt1 induced blood pressure elevation in pre-eclampsia.
AB - Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in human samples. While soluble syndecan-1 and heparan sulphate were similar in plasma of preeclamptic and normotensive pregnant women, dermatan sulphate was increased and keratan sulphate decreased in preeclamptic women. Dermatan sulphate was correlated with soluble syndecan-1, and inversely correlated with blood pressure and activated partial thromboplastin time. To determine if syndecan-1 was a prerequisite for the sFlt1 induced increase in blood pressure in mice we studied the effect of sFlt1 on blood pressure and vascular contractile responses in syndecan-1 deficient and wild type male mice. The classical sFlt1 induced rise in blood pressure was absent in syndecan-1 deficient mice indicating that syndecan-1 is a prerequisite for sFlt1 induced increase in blood pressure central to preeclampsia. The results show that an interplay between syndecan-1 and dermatan sulphate contributes to sFlt1 induced blood pressure elevation in pre-eclampsia.
UR - http://www.scopus.com/inward/record.url?scp=85101527942&partnerID=8YFLogxK
U2 - 10.1038/s41598-021-82972-0
DO - 10.1038/s41598-021-82972-0
M3 - Article
C2 - 33623064
AN - SCOPUS:85101527942
VL - 11
JO - Scientific reports
JF - Scientific reports
SN - 2045-2322
IS - 1
M1 - 4387
ER -
ID: 17474311