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Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19. / Soares, Madu N.; Eggelbusch, Moritz; Naddaf, Elie et al.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 13, No. 1, 02.2022, p. 11-22.

Research output: Contribution to journalReview articleAcademicpeer-review

Harvard

Soares, MN, Eggelbusch, M, Naddaf, E, Gerrits, KHL, van der Schaaf, M, van den Borst, B, Wiersinga, WJ, van Vugt, M, Weijs, PJM, Murray, AJ & Wüst, RCI 2022, 'Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19', Journal of Cachexia, Sarcopenia and Muscle, vol. 13, no. 1, pp. 11-22. https://doi.org/10.1002/jcsm.12896

APA

Soares, M. N., Eggelbusch, M., Naddaf, E., Gerrits, K. H. L., van der Schaaf, M., van den Borst, B., Wiersinga, W. J., van Vugt, M., Weijs, P. J. M., Murray, A. J., & Wüst, R. C. I. (2022). Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19. Journal of Cachexia, Sarcopenia and Muscle, 13(1), 11-22. https://doi.org/10.1002/jcsm.12896

Vancouver

Soares MN, Eggelbusch M, Naddaf E, Gerrits KHL, van der Schaaf M, van den Borst B et al. Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19. Journal of Cachexia, Sarcopenia and Muscle. 2022 Feb;13(1):11-22. https://doi.org/10.1002/jcsm.12896

Author

Soares, Madu N. ; Eggelbusch, Moritz ; Naddaf, Elie et al. / Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19. In: Journal of Cachexia, Sarcopenia and Muscle. 2022 ; Vol. 13, No. 1. pp. 11-22.

BibTeX

@article{65a00955e3364dde8744f94cbbd93ad9,
title = "Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19",
abstract = "Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post-viral fatigue syndrome. Patients with severe Covid-19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid-19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post-intensive care unit (ICU) syndrome and ICU-acquired weakness and likely explain a substantial part of Covid-19-acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS-CoV)-2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS-CoV-2-specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid-19 and PASC.",
keywords = "Covid-19, Inflammation, Metabolism, Muscle wasting, Skeletal muscle",
author = "Soares, {Madu N.} and Moritz Eggelbusch and Elie Naddaf and Gerrits, {Karin H. L.} and {van der Schaaf}, Marike and {van den Borst}, Bram and Wiersinga, {W. Joost} and {van Vugt}, Michele and Weijs, {Peter J. M.} and Murray, {Andrew J.} and W{\"u}st, {Rob C. I.}",
note = "Funding Information: The authors of this manuscript certify that they comply with the ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia and Muscle.121 Publisher Copyright: {\textcopyright} 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.",
year = "2022",
month = feb,
doi = "10.1002/jcsm.12896",
language = "English",
volume = "13",
pages = "11--22",
journal = "JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE",
issn = "2190-5991",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19

AU - Soares, Madu N.

AU - Eggelbusch, Moritz

AU - Naddaf, Elie

AU - Gerrits, Karin H. L.

AU - van der Schaaf, Marike

AU - van den Borst, Bram

AU - Wiersinga, W. Joost

AU - van Vugt, Michele

AU - Weijs, Peter J. M.

AU - Murray, Andrew J.

AU - Wüst, Rob C. I.

N1 - Funding Information: The authors of this manuscript certify that they comply with the ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia and Muscle.121 Publisher Copyright: © 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

PY - 2022/2

Y1 - 2022/2

N2 - Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post-viral fatigue syndrome. Patients with severe Covid-19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid-19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post-intensive care unit (ICU) syndrome and ICU-acquired weakness and likely explain a substantial part of Covid-19-acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS-CoV)-2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS-CoV-2-specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid-19 and PASC.

AB - Skeletal muscle-related symptoms are common in both acute coronavirus disease (Covid)-19 and post-acute sequelae of Covid-19 (PASC). In this narrative review, we discuss cellular and molecular pathways that are affected and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post-viral fatigue syndrome. Patients with severe Covid-19 and PASC suffer from skeletal muscle weakness and exercise intolerance. Histological sections present muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue in patients with severe Covid-19 include systemic inflammation, disuse, hypoxaemia, and malnutrition. These factors also contribute to post-intensive care unit (ICU) syndrome and ICU-acquired weakness and likely explain a substantial part of Covid-19-acquired weakness. The skeletal muscle weakness and exercise intolerance associated with PASC are more obscure. Direct severe acute respiratory syndrome coronavirus (SARS-CoV)-2 viral infiltration into skeletal muscle or an aberrant immune system likely contribute. Similarities between skeletal muscle alterations in PASC and chronic fatigue syndrome deserve further study. Both SARS-CoV-2-specific factors and generic consequences of acute disease likely underlie the observed skeletal muscle alterations in both acute Covid-19 and PASC.

KW - Covid-19

KW - Inflammation

KW - Metabolism

KW - Muscle wasting

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=85122629995&partnerID=8YFLogxK

U2 - 10.1002/jcsm.12896

DO - 10.1002/jcsm.12896

M3 - Review article

C2 - 34997689

VL - 13

SP - 11

EP - 22

JO - JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

JF - JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

SN - 2190-5991

IS - 1

ER -

ID: 21306851