Generic Portal

TY - JOUR

T1 - Serum potassium concentration and its association with hypertension among Ghanaian migrants and non-migrants

T2 - The RODAM study

AU - Ndong, Amie K.

AU - van der Linden, Eva L.

AU - Beune, Erik J. A. J.

AU - Meeks, Karlijn A. C.

AU - Danquah, Ina

AU - Bahendeka, Silver

AU - Klipstein-Grobusch, Kerstin

AU - Schulze, Matthias B.

AU - Addo, Juliet

AU - van den Born, Bert-Jan H.

AU - Agyemang, Charles

N1 - Funding Information: This work was supported by the European Commission under the Framework Program (Grant Number: 278901 ). K.A.C.M. is supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute , the National Institute of Diabetes and Digestive and Kidney Diseases , the Center for Information Technology , and the Office of the Director at the National Institutes of Health ( 1ZIAHG200362 ). Publisher Copyright: © 2021 The Authors

PY - 2021/12/12

Y1 - 2021/12/12

N2 - Background and aims: Low serum potassium concentration is associated with hypertension, but whether the same association can be found in African origin populations, is unknown. We assessed serum potassium concentration, and its association with hypertension among Ghanaians living in different geographical locations. Methods: Baseline data of 962 rural, 1420 urban, and 2947 migrant Ghanaians from the Research on Obesity and Diabetes among African Migrants study were analysed. Mean serum potassium concentration was compared between the groups, and the association between serum potassium and hypertension was assessed using multivariate regression analyses. Results: Mean serum potassium concentration was higher in rural Ghana (4.28, 95% confidence interval 4.25–4.32 mmol/L) than in Ghanaians living in Amsterdam (3.90, 3.88–3.92 mmol/L) and London (4.11, 4.07–4.14 mmol/L), but lower than in Ghanaians living in urban Ghana (4.38, 4.34–4.42 mmol/L) and Berlin (4.57, 4.51–4.62 mmol/L) in both sexes. In the age-adjusted analyses, serum potassium was associated with hypertension in urban- (odds ratio 0.44, 0.23–0.82), London- (0.34, 0.17–0.64) and Amsterdam-Ghanaian males (0.41, 0.20–0.86), and in rural- (0.49, 0.28–0.84), London- (0.29, 0.17–0.49) and Amsterdam-Ghanaian females (0.33, 0.17–0.64). However, after adjustment for demographic, lifestyle, and health factors, serum potassium was associated with hypertension in Amsterdam-Ghanaian males only (0.12, 0.02–0.59). Conclusions: This study shows differences in mean serum potassium among Ghanaian populations living in different locations in Europe and Ghana, and different associations with hypertension between sites. Further research should focus on elucidating the mechanism underlying potassium handling and blood pressure regulation in African populations, in order to mitigate the burden of hypertension among these populations.

AB - Background and aims: Low serum potassium concentration is associated with hypertension, but whether the same association can be found in African origin populations, is unknown. We assessed serum potassium concentration, and its association with hypertension among Ghanaians living in different geographical locations. Methods: Baseline data of 962 rural, 1420 urban, and 2947 migrant Ghanaians from the Research on Obesity and Diabetes among African Migrants study were analysed. Mean serum potassium concentration was compared between the groups, and the association between serum potassium and hypertension was assessed using multivariate regression analyses. Results: Mean serum potassium concentration was higher in rural Ghana (4.28, 95% confidence interval 4.25–4.32 mmol/L) than in Ghanaians living in Amsterdam (3.90, 3.88–3.92 mmol/L) and London (4.11, 4.07–4.14 mmol/L), but lower than in Ghanaians living in urban Ghana (4.38, 4.34–4.42 mmol/L) and Berlin (4.57, 4.51–4.62 mmol/L) in both sexes. In the age-adjusted analyses, serum potassium was associated with hypertension in urban- (odds ratio 0.44, 0.23–0.82), London- (0.34, 0.17–0.64) and Amsterdam-Ghanaian males (0.41, 0.20–0.86), and in rural- (0.49, 0.28–0.84), London- (0.29, 0.17–0.49) and Amsterdam-Ghanaian females (0.33, 0.17–0.64). However, after adjustment for demographic, lifestyle, and health factors, serum potassium was associated with hypertension in Amsterdam-Ghanaian males only (0.12, 0.02–0.59). Conclusions: This study shows differences in mean serum potassium among Ghanaian populations living in different locations in Europe and Ghana, and different associations with hypertension between sites. Further research should focus on elucidating the mechanism underlying potassium handling and blood pressure regulation in African populations, in order to mitigate the burden of hypertension among these populations.

KW - Blood pressure

KW - Europe

KW - Ghana

KW - Hypertension

KW - Migration

KW - Research on Obesity and diabetes among African migrants study

KW - Serum potassium

KW - Sub-Sahara Africa

UR - http://www.scopus.com/inward/record.url?scp=85121715049&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2021.12.006

DO - 10.1016/j.atherosclerosis.2021.12.006

M3 - Article

C2 - 34952692

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -