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Role of the vascular wall in sodium homeostasis and salt sensitivity. / Olde Engberink, Rik H. G.; Rorije, Nienke M. G.; Homan van der Heide, Jaap J. et al.

In: Journal of the American Society of Nephrology, Vol. 26, No. 4, 2015, p. 777-783.

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Olde Engberink, Rik H. G. ; Rorije, Nienke M. G. ; Homan van der Heide, Jaap J. et al. / Role of the vascular wall in sodium homeostasis and salt sensitivity. In: Journal of the American Society of Nephrology. 2015 ; Vol. 26, No. 4. pp. 777-783.

BibTeX

@article{b25785c0b4fd4431a969de8da7ddc126,
title = "Role of the vascular wall in sodium homeostasis and salt sensitivity",
abstract = "Excessive sodium intake is associated with both hypertension and an increased risk of cardiovascular events, presumably because of an increase in extracellular volume. The extent to which sodium intake affects extracellular volume and BP varies considerably among individuals, discriminating subjects who are salt-sensitive from those who are salt-resistant. Recent experiments have shown that, other than regulation by the kidney, sodium homeostasis is also regulated by negatively charged glycosaminoglycans in the skin interstitium, where sodium is bound to glycosaminoglycans without commensurate effects on extracellular volume. The endothelial surface layer is a dynamic layer on the luminal side of the endothelium that is in continuous exchange with flowing blood. Because negatively charged glycosaminoglycans are abundantly present in this layer, it may act as an intravascular buffer compartment that allows sodium to be transiently stored. This review focuses on the putative role of the endothelial surface layer as a contributor to salt sensitivity, the consequences of a perturbed endothelial surface layer on sodium homeostasis, and the endothelial surface layer as a possible target for the treatment of hypertension and an expanded extracellular volume",
author = "{Olde Engberink}, {Rik H. G.} and Rorije, {Nienke M. G.} and {Homan van der Heide}, {Jaap J.} and {van den Born}, {Bert-Jan H.} and Liffert Vogt",
year = "2015",
doi = "10.1681/ASN.2014050430",
language = "English",
volume = "26",
pages = "777--783",
journal = "Journal of the American Society of Nephrology",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "4",

}

RIS

TY - JOUR

T1 - Role of the vascular wall in sodium homeostasis and salt sensitivity

AU - Olde Engberink, Rik H. G.

AU - Rorije, Nienke M. G.

AU - Homan van der Heide, Jaap J.

AU - van den Born, Bert-Jan H.

AU - Vogt, Liffert

PY - 2015

Y1 - 2015

N2 - Excessive sodium intake is associated with both hypertension and an increased risk of cardiovascular events, presumably because of an increase in extracellular volume. The extent to which sodium intake affects extracellular volume and BP varies considerably among individuals, discriminating subjects who are salt-sensitive from those who are salt-resistant. Recent experiments have shown that, other than regulation by the kidney, sodium homeostasis is also regulated by negatively charged glycosaminoglycans in the skin interstitium, where sodium is bound to glycosaminoglycans without commensurate effects on extracellular volume. The endothelial surface layer is a dynamic layer on the luminal side of the endothelium that is in continuous exchange with flowing blood. Because negatively charged glycosaminoglycans are abundantly present in this layer, it may act as an intravascular buffer compartment that allows sodium to be transiently stored. This review focuses on the putative role of the endothelial surface layer as a contributor to salt sensitivity, the consequences of a perturbed endothelial surface layer on sodium homeostasis, and the endothelial surface layer as a possible target for the treatment of hypertension and an expanded extracellular volume

AB - Excessive sodium intake is associated with both hypertension and an increased risk of cardiovascular events, presumably because of an increase in extracellular volume. The extent to which sodium intake affects extracellular volume and BP varies considerably among individuals, discriminating subjects who are salt-sensitive from those who are salt-resistant. Recent experiments have shown that, other than regulation by the kidney, sodium homeostasis is also regulated by negatively charged glycosaminoglycans in the skin interstitium, where sodium is bound to glycosaminoglycans without commensurate effects on extracellular volume. The endothelial surface layer is a dynamic layer on the luminal side of the endothelium that is in continuous exchange with flowing blood. Because negatively charged glycosaminoglycans are abundantly present in this layer, it may act as an intravascular buffer compartment that allows sodium to be transiently stored. This review focuses on the putative role of the endothelial surface layer as a contributor to salt sensitivity, the consequences of a perturbed endothelial surface layer on sodium homeostasis, and the endothelial surface layer as a possible target for the treatment of hypertension and an expanded extracellular volume

U2 - 10.1681/ASN.2014050430

DO - 10.1681/ASN.2014050430

M3 - Review article

C2 - 25294232

VL - 26

SP - 777

EP - 783

JO - Journal of the American Society of Nephrology

JF - Journal of the American Society of Nephrology

SN - 1046-6673

IS - 4

ER -

ID: 2488157