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Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study : a prospective, multinational, observational study. / Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban et al.

In: Critical Care, Vol. 26, No. 1, 276, 12.2022.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Reyes, LF, Murthy, S, Garcia-Gallo, E, Merson, L, Ibáñez-Prada, ED, Rello, J, Fuentes, YV, Martin-Loeches, I, Bozza, F, Duque, S, Taccone, FS, Fowler, RA, Kartsonaki, C, Gonçalves, BP, Citarella, BW, Aryal, D, Burhan, E, Cummings, MJ, Delmas, C, Diaz, R, Figueiredo-Mello, C, Hashmi, M, Panda, PK, Jiménez, MP, Rincon, DFB, Thomson, D, Nichol, A, Marshall, JC, Olliaro, PL, the ISARIC Characterization Group, Abbas, A, Abdukahil, SA, Abe, R, Abel, L, Absil, L, Acharya, S, Acker, A, Adrião, D, Al Ageel, S, Ahmed, S, Ainscough, K, Aisa, T, Hssain, AA, Tamlihat, YA, Akimoto, T, Akmal, E, Al Qasim, E, Alalqam, R, Al-dabbous, T, Alegesan, S, Alegre, C, Alessi, M, Alex, B, Alexandre, KV, Al-Fares, A, Alfoudri, H, Ali, I, Shah, NA, Alidjnou, KE, Aliudin, J, Alkhafajee, Q, Allavena, C, Allou, N, Altaf, A, Alves, J, Alves, JM, Alves, R, Cabrita, JA, Amaral, M, Ampaw, P, Andini, R, Andréjak, C, Angheben, A, Angoulvant, F, Ansart, SV, Antonelli, M, de Brito, CAA, Apriyana, A, Arabi, Y, Aragao, I, 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Borie, R, Bosse, HM, Botelho-Nevers, E, Bouadma, L, Bouchaud, O, Bouchez, S, Bouhmani, D, Bouhour, D, Bouiller, KV, Bouillet, L, Bouisse, C, Boureau, A-S, Bourke, J, Bouscambert, M, Bousquet, A, Bouziotis, J, Boxma, B, Boyer-Besseyre, M, Boylan, M, Braconnier, A, Braga, C, Brandenburger, T, Monteiro, FB, Brazzi, L, Breen, D, Breen, P, Brickell, K, Browne, A, Browne, S, Brusse-Keizer, M, Buchtele, N, Buesaquillo, C, Bugaeva, P, Buisson, M, Burrell, A, Bustos, IG, Butnaru, D, Cabie, A, Cabral, S, Caceres, E, Cadoz, C, Garcês, RC, Calligy, K, Calvache, JA, Camões, J, Campana, V, Campbell, P, Canepa, C, Cantero, M, Caraux-Paz, P, Cárcel, S, Cardellino, CS, Cardoso, F, Cardoso, F, Cardoso, N, Cardoso, S, Carelli, S, Carlier, N, Carmoi, T, Carney, G, Carqueja, I, Carret, M-C, Carrier, FM, Carroll, I, Carson, G, Casanova, M-L, Cascão, M, Casey, S, Casimiro, J, Cassandra, B, Castañeda, S, Castanheira, N, Castor-Alexandre, G, Castrillón, H, Castro, I, Catarino, A, Catherine, F-X, Cattaneo, P, 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APA

Reyes, L. F., Murthy, S., Garcia-Gallo, E., Merson, L., Ibáñez-Prada, E. D., Rello, J., Fuentes, Y. V., Martin-Loeches, I., Bozza, F., Duque, S., Taccone, F. S., Fowler, R. A., Kartsonaki, C., Gonçalves, B. P., Citarella, B. W., Aryal, D., Burhan, E., Cummings, M. J., Delmas, C., ... Zucman, D. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Critical Care, 26(1), [276]. https://doi.org/10.1186/s13054-022-04155-1

Vancouver

Reyes LF, Murthy S, Garcia-Gallo E, Merson L, Ibáñez-Prada ED, Rello J et al. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Critical Care. 2022 Dec;26(1):276. doi: 10.1186/s13054-022-04155-1

Author

Reyes, Luis Felipe ; Murthy, Srinivas ; Garcia-Gallo, Esteban et al. / Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study : a prospective, multinational, observational study. In: Critical Care. 2022 ; Vol. 26, No. 1.

BibTeX

@article{bbf5effd21bb43d9b3477be8cf4c1e6e,
title = "Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study",
abstract = "Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.",
keywords = "COVID-19, Critical care, High flow nasal cannula, Invasive mechanical ventilation",
author = "Reyes, {Luis Felipe} and Srinivas Murthy and Esteban Garcia-Gallo and Laura Merson and Ib{\'a}{\~n}ez-Prada, {Elsa D.} and Jordi Rello and Fuentes, {Yuli V.} and Ignacio Martin-Loeches and Fernando Bozza and Sara Duque and Taccone, {Fabio S.} and Fowler, {Robert A.} and Christiana Kartsonaki and Gon{\c c}alves, {Bronner P.} and Citarella, {Barbara Wanjiru} and Diptesh Aryal and Erlina Burhan and Cummings, {Matthew J.} and Christelle Delmas and Rodrigo Diaz and Claudia Figueiredo-Mello and Madiha Hashmi and Panda, {Prasan Kumar} and Jim{\'e}nez, {Miguel Pedrera} and Rincon, {Diego Fernando Bautista} and David Thomson and Alistair Nichol and Marshall, {John C.} and Olliaro, {Piero L.} and {the ISARIC Characterization Group} and Ali Abbas and Abdukahil, {Sheryl Ann} and Ryuzo Abe and Laurent Abel and Lara Absil and Subhash Acharya and Andrew Acker and Diana Adri{\~a}o and {Al Ageel}, Saleh and Shakeel Ahmed and Kate Ainscough and Tharwat Aisa and Hssain, {Ali Ait} and Tamlihat, {Younes Ait} and Takako Akimoto and Ernita Akmal and {Al Qasim}, Eman and Razi Alalqam and Tala Al-dabbous and Senthilkumar Alegesan and Cynthia Alegre and Marta Alessi and Beatrice Alex and Alexandre, {K. vin} and Abdulrahman Al-Fares and Huda Alfoudri and Imran Ali and Shah, {Naseem Ali} and Alidjnou, {Kazali Enagnon} and Jeffrey Aliudin and Qabas Alkhafajee and Clotilde Allavena and Nathalie Allou and Aneela Altaf and Jo{\~a}o Alves and Alves, {Jo{\~a}o Melo} and Rita Alves and Cabrita, {Joana Alves} and Maria Amaral and Phoebe Ampaw and Roberto Andini and Claire Andr{\'e}jak and Andrea Angheben and Fran{\c c}ois Angoulvant and Ansart, {S. verine} and Massimo Antonelli and {de Brito}, {Carlos Alexandre Antunes} and Ardiyan Apriyana and Yaseen Arabi and Irene Aragao and Carolline Araujo and Antonio Arcadipane and Patrick Archambault and Lukas Arenz and Jean-Beno{\^i}t Arlet and Christel Arnold-Day and Lovkesh Arora and Rakesh Arora and Elise Artaud-Macari and Angel Asensio and Namra Asif and Mohammad Asim and Assie, {Jean Baptiste} and Anika Atique and Attanyake, {A. M. Udara Lakshan} and Johann Auchabie and Hugues Aumaitre and Adrien Auvet and Laur{\`e}ne Azemar and Cecile Azoulay and Benjamin Bach and Delphine Bachelet and Claudine Badr and Nadia Baig and Baillie, {J. Kenneth} and Erica Bak and Agamemnon Bakakos and Andriy Bal and Valeria Balan and Firouz{\'e} Bani-Sadr and Renata Barbalho and Barclay, {Wendy S.} and Michaela Barnikel and Helena Barrasa and Audrey Barrelet and Cleide Barrigoto and Marie Bartoli and Joaqu{\'i}n Baruch and Romain Basmaci and Denise Battaglini and Jules Bauer and Dow, {Denisse Bazan} and Abigail Beane and Alexandra Bedossa and Husna Begum and Sylvie Behilill and Albertus Beishuizen and Aleksandr Beljantsev and David Bellemare and Anna Beltrame and Marine Beluze and Nicolas Benech and Dehbia Benkerrou and Suzanne Bennett and Lu{\'i}s Bento and Jan-Erik Berdal and Delphine Bergeaud and Hazel Bergin and Sobrino, {Jos{\'e} Luis Bernal} and Giulia Bertoli and Lorenzo Bertolino and Simon Bessis and Sybille Bevilcaqua and Karine Bezulier and Amar Bhatt and Krishna Bhavsar and Claudia Bianco and Singh, {Moirangthem Bikram} and Humaid, {Felwa Bin} and Fran{\c c}ois Bissuel and Laurent Bitker and Jonathan Bitton and Pablo Blanco-Schweizer and Catherine Blier and Frank Bloos and Mathieu Blot and Filomena Boccia and Laetitia Bodenes and Debby Bogaert and Boivin, {Anne-H. l{\`e}ne} and Pierre-Adrien Bolze and Fran{\c c}ois Bompart and Diogo Borges and Rapha{\"e}l Borie and Bosse, {Hans Martin} and Elisabeth Botelho-Nevers and Lila Bouadma and Olivier Bouchaud and Sabelline Bouchez and Dounia Bouhmani and Damien Bouhour and Bouiller, {K. vin} and Laurence Bouillet and Camile Bouisse and Anne-Sophie Boureau and John Bourke and Maude Bouscambert and Aurore Bousquet and Jason Bouziotis and Bianca Boxma and Marielle Boyer-Besseyre and Maria Boylan and Axelle Braconnier and Cynthia Braga and Timo Brandenburger and Monteiro, {Filipa Br{\'a}s} and Luca Brazzi and Dorothy Breen and Patrick Breen and Kathy Brickell and Alex Browne and Shaunagh Browne and Marjolein Brusse-Keizer and Nina Buchtele and Christian Buesaquillo and Polina Bugaeva and Marielle Buisson and Aidan Burrell and Bustos, {Ingrid G.} and Denis Butnaru and Andr{\'e} Cabie and Susana Cabral and Eder Caceres and Cyril Cadoz and Garc{\^e}s, {Rui Caetano} and Kate Calligy and Calvache, {Jose Andres} and Jo{\~a}o Cam{\~o}es and Valentine Campana and Paul Campbell and Cecilia Canepa and Mireia Cantero and Pauline Caraux-Paz and Sheila C{\'a}rcel and Cardellino, {Chiara Simona} and Filipa Cardoso and Filipe Cardoso and Nelson Cardoso and Sofia Cardoso and Simone Carelli and Nicolas Carlier and Thierry Carmoi and Gayle Carney and In{\^e}s Carqueja and Marie-Christine Carret and Carrier, {Fran{\c c}ois Martin} and Ida Carroll and Gail Carson and Maire-Laure Casanova and Mariana Casc{\~a}o and Siobhan Casey and Jos{\'e} Casimiro and Bailey Cassandra and Silvia Casta{\~n}eda and Nidyanara Castanheira and Guylaine Castor-Alexandre and Henry Castrill{\'o}n and Ivo Castro and Ana Catarino and Fran{\c c}ois-Xavier Catherine and Paolo Cattaneo and Roberta Cavalin and Cavalli, {Giulio Giovanni} and Alexandros Cavayas and Adrian Ceccato and Minerva Cervantes-Gonzalez and Anissa Chair and Catherine Chakveatze and Adrienne Chan and Meera Chand and Auger, {Christelle Chantalat} and Jean-Marc Chapplain and Julie Chas and Mobin Chaudry and I{\~n}iguez, {Jonathan Samuel Ch{\'a}vez} and Anjellica Chen and Yih-Sharng Chen and Cheng, {Matthew Pellan} and Antoine Cheret and Thibault Chiarabini and Julian Chica and Catherine Chirouze and Davide Chiumello and Sung-Min Cho and Bernard Cholley and Marie-Charlotte Chopin and Cidade, {Jose Pedro} and Herreros, {Jos{\'e} Miguel Cisneros} and Anna Ciullo and Emma Clarke and Jennifer Clarke and Sara Clohisey and Cobb, {Perren J.} and Cassidy Codan and Caitriona Cody and Alexandra Coelho and Megan Coles and Gwenha{\"e}l Colin and Michael Collins and Colombo, {Sebastiano Maria} and Pamela Combs and Marie Connor and Anne Conrad and Sof{\'i}a Contreras and Elaine Conway and Cooke, {Graham S.} and Mary Copland and Hugues Cordel and Amanda Corley and Sabine Cornelis and Cornet, {Alexander Daniel} and Corpuz, {Arianne Joy} and Andrea Cortegiani and Gr{\'e}gory Corvaisier and Emma Costigan and Camille Couffignal and Sandrine Couffin-Cadiergues and Roxane Courtois and St{\'e}phanie Cousse and Rachel Cregan and Sabine Croonen and Gloria Crowl and Jonathan Crump and Claudina Cruz and Berm{\'u}dez, {Juan Luis Cruz} and Rojo, {Jaime Cruz} and Marc Csete and Ailbhe Cullen and Ger Curley and Elodie Curlier and Colleen Curran and Paula Custodio and {da Silva Filipe}, Ana and {da Silveira}, Charlene and Al-Awwab Dabaliz and Andrew Dagens and Darren Dahly and Heidi Dalton and Jo Dalton and Seamus Daly and Juliana Damas and Nick Daneman and Corinne Daniel and Dankwa, {Emmanuelle A.} and Jorge Dantas and Fr{\'e}d{\'e}rick D{\textquoteright}Aragon and {de Loughry}, Gillian and {de Mendoza}, Diego and {de Montmollin}, Etienne and {de Oliveira Fran{\c c}a}, {Rafael Freitas} and {de Pinho Oliveira}, {Ana Isabel} and {de Rosa}, Rosanna and {de Silva}, Thushan and {de Vries}, Peter and Jillian Deacon and David Dean and Alexa Debard and Marie-Pierre Debray and Nathalie DeCastro and William Dechert and Lauren Deconninck and Romain Decours and Eve Defous and Isabelle Delacroix and Eric Delaveuve and Karen Delavigne and Andrea Dell{\textquoteright}Amore and Pierre Delobel and Corine Delsing and Elisa Demonchy and Emmanuelle Denis and Dominique Deplanque and Pieter Depuydt and Diane Descamps and Mathilde Desvall{\'e}es and Santi Dewayanti and Pathik Dhanger and Alpha Diallo and Sylvain Diamantis and Andr{\'e} Dias and Diaz, {Juan Jose} and Priscila Diaz and Didier, {K. vin} and Jean-Luc Diehl and Wim Dieperink and Dimet, {J. r{\^o}me} and Vincent Dinot and Fara Diop and Alphonsine Diouf and Yael Dishon and Djossou, {F. lix} and Docherty, {Annemarie B.} and Helen Doherty and Dondorp, {Arjen M.} and Donnelly, {Christl A.} and Maria Donnelly and Chloe Donohue and Sean Donohue and Yoann Donohue and Peter Doran and Dorival, {C. line} and Eric D{\textquoteright}Ortenzio and Douglas, {James Joshua} and Nathalie Dournon and Triona Downer and Joanne Downey and Mark Downing and Tom Drake and Aoife Driscoll and Fonseca, {Claudio Duarte} and Vincent Dubee and Fran{\c c}ois Dubos and Alexandre Ducancelle and Susanne Dudman and Paul Dunand and Jake Dunning and Mathilde Duplaix and Emanuele Durante-Mangoni and Lucian Durham and Bertrand Dussol and Juliette Duthoit and Xavier Duval and Dyrhol-Riise, {Anne Margarita} and Marco Echeverria-Villalobos and Siobhan Egan and Carla Eira and Sanharawi, {Mohammed El} and Subbarao Elapavaluru and Brigitte Elharrar and Jacobien Ellerbroek and Philippine Eloy and Tarek Elshazly and Isabelle Enderle and Tomoyuki Endo and Ilka Engelmann and Vincent Enouf and Olivier Epaulard and Martina Escher and Mariano Esperatti and Esperou, {H. l{\`e}ne} and Santo, {Catarina Esp{\'i}rito} and Marina Esposito-Farese and Jo{\~a}o Estev{\~a}o and Manuel Etienne and Nadia Ettalhaoui and Everding, {Anna Greti} and Mirjam Evers and Isabelle Fabre and Marc Fabre and Amna Faheem and Arabella Fahy and Fairfield, {Cameron J.} and Zul Fakar and Komal Fareed and Pedro Faria and Ahmed Farooq and Fatoni, {Arie Zainul} and Karine Faure and Rapha{\"e}l Favory and Mohamed Fayed and Niamh Feely and Laura Feeney and Jorge Fernandes and Fernandes, {Mar{\'i}lia Andreia} and Susana Fernandes and Fran{\c c}ois-Xavier Ferrand and Devouge, {Eglantine Ferrand} and Joana Ferr{\~a}o and Ferraz, {M. rio} and Benigno Ferreira and Bernardo Ferreira and Isabel Ferreira and Ferreira, {S. lvia} and Ricard Ferrer-Roca and Nicolas Ferriere and Ficko, {C. line} and Juan Fiorda and Thomas Flament and Clara Flateau and Tom Fletcher and Florio, {Letizia Lucia} and Deirdre Flynn and Claire Foley and Jean Foley and Victor Fomin and Tatiana Fonseca and Patricia Fontela and Simon Forsyth and Denise Foster and Giuseppe Foti and Erwan Fourn and Marianne Fraher and Diego Franch-Llasat and Christophe Fraser and Fraser, {John F.} and Freire, {Marcela Vieira} and Ribeiro, {Ana Freitas} and Craig French and Caren Friedrich and St{\'e}phanie Fry and Nora Fuentes and Masahiro Fukuda and G. Argin and Val{\'e}rie Gaborieau and Rostane Gaci and Massimo Gagliardi and Jean-Charles Gagnard and Amandine Gagneux-Brunon and Gai{\~a}o, {S. rgio} and Skeie, {Linda Gail} and Phil Gallagher and Carrol Gamble and Arthur Garan and Rebekha Garcia and Barrio, {Noelia Garc{\'i}a} and Navya Garimella and Denis Garot and Val{\'e}rie Garrait and Basanta Gauli and Nathalie Gault and Aisling Gavin and Anatoliy Gavrylov and Alexandre Gaymard and Johannes Gebauer and Eva Geraud and Morlaes, {Louis Gerbaud} and Nuno Germano and Jade Ghosn and Marco Giani and Jess Gibson and Tristan Gigante and Morgane Gilg and Elaine Gilroy and Guillermo Giordano and Michelle Girvan and Val{\'e}rie Gissot and Daniel Glikman and Petr Glybochko and Eric Gnall and Geraldine Goco and Fran{\c c}ois Goehringer and Siri Goepel and Jean-Christophe Goffard and Jonathan Golob and Joan G{\'o}mez-Junyent and Marie Gominet and Alicia Gonzalez and Patricia Gordon and Isabelle Gorenne and Laure Goubert and Goujard, {C. cile} and Tiphaine Goulenok and Margarite Grable and Jeronimo Graf and Grandin, {Edward Wilson} and Pascal Granier and Giacomo Grasselli and Green, {Christopher A.} and Courtney Greene and William Greenhalf and Segol{\`e}ne Greffe and Grieco, {Domenico Luca} and Matthew Griffee and Fiona Griffiths and Albert Groenendijk and Lordemann, {Anja Grosse} and Heidi Gruner and Yusing Gu and Guedj, {J. r{\'e}mie} and Martin Guego and Dewi Guellec and Anne-Marie Guerguerian and Daniela Guerreiro and Romain Guery and Anne Guillaumot and Laurent Guilleminault and {de Castro}, {Maisa Guimar{\~a}es} and Thomas Guimard and Marieke Haalboom and Daniel Haber and Hannah Habraken and Ali Hachemi and Nadir Hadri and Fakhir Haidri and Sheeba Hakak and Adam Hall and Matthew Hall and Sophie Halpin and Jawad Hameed and Ansley Hamer and Rebecca Hamidfar and Terese Hammond and Rashan Haniffa and Hayley Hardwick and Harrison, {Ewen M.} and Janet Harrison and Harrison, {Samuel Bernard Ekow} and Hasan, {Mohd Shahnaz} and Junaid Hashmi and Muhammad Hayat and Ailbhe Hayes and Leanne Hays and Jan Heerman and Lars Heggelund and Ross Hendry and Martina Hennessy and Maxime Hentzien and Andrew Hershey and Liv Hesstvedt and Astarini Hidayah and Dawn Higgins and Eibhilin Higgins and Rupert Higgins and Rita Hinchion and Samuel Hinton and Hikombo Hitoto and Antonia Ho and Alexandre Hoctin and Isabelle Hoffmann and Oscar Hoiting and Rebecca Holt and Holter, {Jan Cato} and Peter Horby and Horcajada, {Juan Pablo} and Koji Hoshino and Kota Hoshino and Ikram Houas and Hough, {Catherine L.} and Hsu, {Jimmy Ming-Yang} and Hulot, {Jean-S. bastien} and Stella Huo and Abby Hurd and Iqbal Hussain and Samreen Ijaz and Arfan Ikram and Hajnal-Gabriela Illes and Patrick Imbert and Mohammad Imran and Sikander, {Rana Imran} and Aftab Imtiaz and Hugo In{\'a}cio and Dominguez, {Carmen Infante} and Mariachiara Ippolito and Sarah Isgett and Tiago Isidoro and Margaux Isnard and Daniel Ivulich and Danielle Jaafar and Salma Jaafoura and Julien Jabot and Clare Jackson and Nina Jamieson and Pierre Jaquet and Coline Jaud-Fischer and St{\'e}phane Jaureguiberry and Florence Jego and Synne Jenum and Garc{\'i}a, {Ruth N. Jorge} and Joseph, {C. dric} and Mark Joseph and Swosti Joshi and Merc{\'e} Jourdain and Philippe Jouvet and Anna Jung and Dafsah Juzar and Ouifiya Kafif and Florentia Kaguelidou and Sabina Kali and Smaragdi Kalomoiri and Kandamby, {Darshana Hewa} and Chris Kandel and Darakhshan Kanwal and Anant Kataria and Kevin Katz and Christy Kay and Hannah Keane and Se{\'a}n Keating and Andrea Kelly and Aoife Kelly and Claire Kelly and Niamh Kelly and Sadie Kelly and Yvelynne Kelly and Maeve Kelsey and Kalynn Kennon and Maeve Kernan and Younes Kerroumi and Sharma Keshav and Imrana Khalid and Osama Khalid and Antoine Khalil and Coralie Khan and Irfan Khan and Khan, {Quratul Ain} and Sushil Khanal and Abid Khatak and Amin Khawaja and Kho, {Michelle E.} and Saye Khoo and Nasir Khoso and Yuri Kida and Peter Kiiza and Granerud, {Beathe Kiland} and Kildal, {Anders Benjamin} and Antoine Kimmoun and Detlef Kindgen-Milles and Nobuya Kitamura and Paul Klenerman and Rob Klont and Bekken, {Gry Kloumann} and Knight, {Stephen R.} and Robin Kobbe and Chamira Kodippily and Vasconcelos, {Malte Kohns} and Sabin Koirala and Caroline Kosgei and Ars{\`e}ne Kpangon and Karolina Krawczyk and Oksana Kruglova and Deepali Kumar and Mukesh Kumar and Vijayaraghavan, {Bharath Kumar Tirupakuzhi} and Vecham, {Pavan Kumar} and Dinesh Kuriakose and Ethan Kurtzman and Demetrios Kutsogiannis and Galyna Kutsyna and Konstantinos Kyriakoulis and Marie Lachatre and Marie Lacoste and Laffey, {John G.} and Marie Lagrange and Fabrice Laine and Olivier Lairez and Sanjay Lakhey and Antonio Lalueza and Marc Lambert and Fran{\c c}ois Lamontagne and Marie Langelot-Richard and Vincent Langlois and Lantang, {Eka Yudha} and Marina Lanza and Laou{\'e}nan, {C. dric} and Samira Laribi and Delphine Lariviere and St{\'e}phane Lasry and Naveed Latif and Odile Launay and Didier Laureillard and Yoan Lavie-Badie and Andrew Law and Cassie Lawrence and Teresa Lawrence and Minh le and {le Bihan}, Cl{\'e}ment and {le Bris}, Cyril and {le Falher}, Georges and {le Fevre}, Lucie and {le Hingrat}, Quentin and {le Mar{\'e}chal}, Marion and {le Mestre}, Soizic and {le Moal}, Gwena{\"e}l and {le Moing}, Vincent and {le Nagard}, Herv{\'e} and {le Turnier}, Paul and Ema Leal and Santos, {Marta Leal} and James Lee and Jennifer Lee and Lee, {Su Hwan} and Lee, {Todd C.} and Gary Leeming and Lefebvre, {B. n{\'e}dicte} and Laurent Lefebvre and Benjamin Lef{\`e}vre and Sylvie LeGac and Jean-Daniel Lelievre and Fran{\c c}ois Lellouche and Adrien Lemaignen and Lemee, {V. ronique} and Anthony Lemeur and Gretchen Lemmink and Jenny Lennon and Rafael Le{\'o}n and Marc Leone and Michela Leone and Fran{\c c}ois-Xavier Lescure and Olivier Lesens and Mathieu Lesouhaitier and Amy Lester-Grant and Bruno Levy and Yves Levy and Claire Levy-Marchal and Katarzyna Lewandowska and Erwan l{\textquoteright}Her and Bassi, {Gianluigi Li} and Ali Liaquat and Geoffrey Liegeon and Lim, {Wei Shen} and Chantre Lima and Bruno Lina and Andreas Lind and Guillaume Lingas and Sylvie Lion-Daolio and Keibun Liu and Marine Livrozet and Patricia Lizotte and Antonio Loforte and Navy Lolong and Diogo Lopes and Loschner, {Anthony L.} and Paul Loubet and Bouchra Loufti and Guillame Louis and Silvia Lourenco and Lara Lovelace-Macon and Marije Lowik and Lucet, {Jean Christophe} and Bermejo, {Carlos Lumbreras} and Luna, {Carlos M.} and Liem Luong and Nestor Luque and Dominique Luton and Nilar Lwin and Ruth Lyons and Olavi Maasikas and Oryane Mabiala and Mo{\"i}se Machado and Sara Machado and Gabriel Macheda and Hashmi Madiha and {de la Calle}, {Guillermo Maestro} and Rafael Mahieu and Sophie Mahy and Maia, {Ana Raquel} and Maier, {Lars S.} and Myl{\`e}ne Maillet and Thomas Maitre and Maximilian Malfertheiner and Nadia Malik and Paddy Mallon and Fernando Maltez and Denis Malvy and Victoria Manda and Laurent Mandelbrot and Julie Mankikian and Edmund Manning and Aldric Manuel and Sant, {Ceila Maria} and Ana Malaque and Daniel Marino and Fl{\'a}vio Marino and Samuel Markowicz and Ana Marques and Catherine Marquis and Brian Marsh and Laura Marsh and Megan Marshal and Martelli, {Celina Turchi} and Emily Martin and Guillaume Martin-Blondel and Martin Martinot and Ana Martins and Jo{\~a}o Martins and Nuno Martins and Rego, {Caroline Martins} and Gennaro Martucci and Olga Martynenko and Marwali, {Eva Miranda} and David Maslove and Sabina Mason and Sobia Masood and Nor, {Basri Mat} and Nor, {Basri Mat} and Moshe Matan and Meghena Mathew and Daniel Mathieu and Mathieu Mattei and Romans Matulevics and Laurence Maulin and Michael Maxwell and Javier Maynar and Thierry Mazzoni and {Mc Evoy}, Natalie and {Mc Sweeney}, Lisa and Colin McArthur and Colin McArthur and Aine McCarthy and Anne McCarthy and Colin McCloskey and Rachael McConnochie and Sherry McDermott and McDonald, {Sarah E.} and Aine McElroy and Samuel McElwee and Victoria McEneany and Allison McGeer and Chris McKay and Johnny McKeown and McLean, {Kenneth A.} and Paul McNally and Bairbre McNicholas and Elaine McPartlan and Edel Meaney and Mear-Passard, {C. cile} and Maggie Mechlin and Minahel Atif and Maqsood Meher and Ferruccio Mele and Luis Melo and Kashif Memon and Mendes, {Joao Joao} and Ogechukwu Menkiti and Kusum Menon and France Mentr{\'e} and Mentzer, {Alexander J.} and Emmanuelle Mercier and No{\'e}mie Mercier and Antoine Merckx and Mayka Mergeay-Fabre and Blake Mergler and Ant{\'o}nio Mesquita and Osama Metwally and Agn{\`e}s Meybeck and Dan Meyer and Meynert, {Alison M.} and Vanina Meysonnier and Amina Meziane and Mehdi Mezidi and Michelanglei, {C. line} and Isabelle Michelet and Vladislav Mihnovit and Asma Moin and David Molina and Elena Molinos and Brenda Molloy and Mary Mone and Agostinho Monteiro and Claudia Montes and Giorgia Montrucchio and Sarah Moore and Moore, {Shona C.} and Cely, {Lina Morales} and Lucia Moro and Catherine Motherway and Ana Motos and Hugo Mouquet and Perrot, {Clara Mouton} and Julien Moyet and Mufti, {Aisha Kalsoom} and Jimmy Mullaert and Fredrik M{\"u}ller and M{\"u}ller, {Karl Erik} and Daniel Munblit and Syed Muneeb and Nadeem Munir and Aisling Murphy and Aisling Murphy and Lorna Murphy and Marl{\`e}ne Murris and Himed Musaab and Himasha Muvindi and Myrodia, {Dimitra Melia} and Mohd-Hanafiah, {Farah Nadia} and Dave Nagpal and Alex Nagrebetsky and Nageswaran Narayanan and Khan, {Rashid Nasim} and Alasdair Nazerali-Maitland and Nad{\`e}ge Neant and Nikita Nekliudov and Raul Neto and Emily Neumann and Ng, {Pauline Yeung} and Anthony Nghi and Duc Nguyen and Choileain, {Orna Ni} and Leathlobhair, {Niamh Ni} and Prompak Nitayavardhana and Stephanie Nonas and Marion Noret and Lisa Norman and Alessandra Notari and Mahdad Noursadeghi and Adam Nowinski and Saad Nseir and Nunez, {Jose I.} and Nurnaningsih Nurnaningsih and Elsa Nyamankolly and Brien, {Fionnuala O.} and Callaghan, {Annmarie O.} and Annmarie O{\textquoteright}Callaghan and Giovanna Occhipinti and Derbrenn OConnor and Max O{\textquoteright}Donnell and Tawnya Ogston and Takayuki Ogura and Sophie O{\textquoteright}Halloran and Katie O{\textquoteright}Hearn and Jo{\~a}o Oliveira and Larissa Oliveira and Ong, {David S. Y.} and Wilna Oosthuyzen and Anne Opavsky and Peter Openshaw and Saijad Orakzai and Orozco-Chamorro, {Claudia Milena} and Jamel Ortoleva and Javier Osatnik and Linda O{\textquoteright}Shea and Miriam O{\textquoteright}Sullivan and Nadia Ouamara and Rachida Ouissa and Eric Oziol and Ma{\"i}der Pagadoy and Justine Pages and Amanda Palacios and Mario Palacios and Massimo Palmarini and Giovanna Panarello and Hem Paneru and Mauro Panigada and Nathalie Pansu and Aur{\'e}lie Papadopoulos and Rachael Parke and Melissa Parker and Briseida Parra and Taha Pasha and Pasquier, {J. r{\'e}mie} and Bruno Pastene and Fabian Patauner and Lu{\'i}s Patr{\~a}o and Patricia Patricio and Juliette Patrier and Lisa Patterson and Rajyabardhan Pattnaik and Christelle Paul and Mical Paul and Jorge Paulos and Paxton, {William A.} and Jean-Fran{\c c}ois Payen and Florent Peelman and Nathan Peiffer-Smadja and Vincent Peigne and Mare Pejkovska and Paolo Pelosi and Peltan, {Ithan D.} and Rui Pereira and Daniel Perez and Luis Periel and Thomas Perpoint and Antonio Pesenti and Vincent Pestre and Lenka Petrou and Michele Petrovic and Ventzislava Petrov-Sanchez and Pettersen, {Frank Olav} and Gilles Peytavin and Scott Pharand and Walter Picard and Olivier Picone and Carola Pierobon and Djura Piersma and Carlos Pimentel and Raquel Pinto and Catarina Pires and Isabelle Pironneau and Lionel Piroth and Riinu Pius and Laurent Plantier and Julien Poissy and Ryadh Pokeerbux and Sergio Poli and Georgios Pollakis and Diane Ponscarme and Andra-Maris Post and Postma, {Douwe F.} and Pedro Povoa and Diana P{\'o}voas and Jeff Powis and Sofia Prapa and Preau, {S. bastien} and Christian Prebensen and Jean-Charles Preiser and Anton Prinssen and Pritchard, {Mark G.} and Priyadarshani, {Gamage Dona Dilanthi} and Lucia Proen{\c c}a and Sravya Pudota and Oriane Pu{\'e}chal and Semedi, {Bambang Pujo} and Mathew Pulicken and Gregory Purcell and Luisa Quesada and Vilmaris Quinones-Cardona and Gonz{\'a}lez, {V. ctor Quir{\'o}s} and Else Quist-Paulsen and Mohammed Quraishi and Christian Rabaud and Ebenezer Rabindrarajan and Aldo Rafael and Marie Rafiq and Arsalan Rahutullah and Fernando Rainieri and Pratheema Ramachandran and Nagarajan Ramakrishnan and Jos{\'e} Ramalho and Blandine Rammaert and Ramos, {Grazielle Viana} and Asim Rana and Rajavardhan Rangappa and Ritika Ranjan and Christophe Rapp and Aasiyah Rashan and Thalha Rashan and Ghulam Rasheed and Menaldi Rasmin and Indrek R{\"a}tsep and Cornelius Rau and Ali Raza and Andre Real and Stanislas Rebaudet and Sarah Redl and Brenda Reeve and Attaur Rehman and Liadain Reid and Liadain Reid and Reikvam, {Dag Henrik} and Renato Reis and Jonathan Remppis and Martine Remy and Hongru Ren and Hanna Renk and Anne-Sophie Resseguier and Matthieu Revest and Oleksa Rewa and Tiago Reyes and Ribeiro, {Maria Ines} and David Richardson and Denise Richardson and Laurent Richier and Jordi Riera and Rios, {Ana L.} and Asgar Rishu and Patrick Rispal and Karine Risso and Nicholas Rizer and Chiara Robba and Andr{\'e} Roberto and Stephanie Roberts and Robertson, {David L.} and Olivier Robineau and Ferran Roche-Campo and Paola Rodari and Sim{\~a}o Rodeia and Abreu, {Julia Rodriguez} and Bernhard Roessler and Pierre-Marie Roger and Amanda Rojek and Juliette Romaru and Roberto Roncon-Albuquerque and Roriz, {M. lanie} and Manuel Rosa-Calatrava and Michael Rose and Dorothea Rosenberger and Andrea Rossanese and Matteo Rossetti and Rossignol, {B. n{\'e}dicte} and Patrick Rossignol and Stella Rousset and Carine Roy and Beno{\^i}t Roze and Desy Rusmawatiningtyas and Russell, {Clark D.} and Maeve Ryan and Maria Ryan and Steffi Ryckaert and Holten, {Aleksander Rygh} and Isabela Saba and Sairah Sadaf and Musharaf Sadat and Valla Sahraei and Nadia Saidani and Maximilien Saint-Gilles and Pranya Sakiyalak and Nawal Salahuddin and Leonardo Salazar and Jodat Saleem and Gabriele Sales and St{\'e}phane Sallaberry and Gandonniere, {Charlotte Salmon} and Salvator, {H. l{\`e}ne} and Olivier Sanchez and Angel Sanchez-Miralles and Vanessa Sancho-Shimizu and Gyan Sandhu and Zulfiqar Sandhu and Pierre-Fran{\c c}ois Sandrine and Oana Sandulescu and Marlene Santos and Shirley Sarfo-Mensah and Banheiro, {Bruno Sarmento} and Benjamine Sarton and Sree Satyapriya and Rumaisah Satyawati and Egle Saviciute and Justin Schaffer and Tjard Schermer and Arnaud Scherpereel and Marion Schneider and Stephan Schroll and Michael Schwameis and Scott, {Janet T.} and James Scott-Brown and Nicholas Sedillot and Tamara Seitz and Jaganathan Selvanayagam and Caroline Semaille and Semple, {Malcolm G.} and Eric Senneville and Filipa Sequeira and Sequeira, {T. nia} and Neto, {Ary Serpa} and Balazote, {Pablo Serrano} and Ellen Shadowitz and Mohammad Shamsah and Shaikh Sharjeel and Pratima Sharma and Shaw, {Catherine A.} and Victoria Shaw and Ashraf Sheharyar and Shetty, {Rajesh Mohan} and Haixia Shi and Mohiuddin Shiekh and Keiki Shimizu and Sally Shrapnel and Shrestha, {Shubha Kalyan} and Shrestha, {Pramesh Sundar} and Shum, {Hoi Ping} and Mohammed, {Nassima Si} and Jeanne Sibiude and Atif Siddiqui and Louise Sigfrid and Piret Sillaots and Catarina Silva and Silva, {Maria Joao} and Rog{\'e}rio Silva and Sin, {Wai Ching} and Singh, {Budha Charan} and Punam Singh and Sitompul, {Pompini Agustina} and Vegard Skogen and Sue Smith and Benjamin Smood and Coilin Smyth and Michelle Smyth and Michelle Smyth and Morgane Snacken and Dominic So and Joshua Solomon and Tom Solomon and Emily Somers and Agn{\`e}s Sommet and Song, {Myung Jin} and Rima Song and Tae Song and Chia, {Jack Song} and Albert Sotto and Edouard Soum and Sousa, {Ana Chora} and Marta Sousa and Uva, {Maria Sousa} and Alexandra Sperry and Elisabetta Spinuzza and Darshana, {B. P. Sanka Ruwan Sri} and Shiranee Sriskandan and Sarah Stabler and Thomas Staudinger and Stephanie-Susanne Stecher and Ymkje Stienstra and Birgitte Stiksrud and Eva Stolz and Amy Stone and Adrian Streinu-Cercel and Anca Streinu-Cercel and Ami Stuart and David Stuart and Gabriel Suen and Suen, {Jacky Y.} and Asfia Sultana and Charlotte Summers and Dubravka Supic and Magdalena Surovcov{\'a} and Andrey Svistunov and Konstantinos Syrigos and Jaques Sztajnbok and Konstanty Szuldrzynski and Shirin Tabrizi and Lysa Tagherset and Sara Taleb and Jelmer Talsma and Tampubolon, {Maria Lawrensia} and Hiroyuki Tanaka and Huda Taqdees and Arshad Taqi and Coralie Tardivon and Pierre Tattevin and Taufik, {M. Azhari} and Hassan Tawfik and Tedder, {Richard S.} and Jo{\~a}o Teixeira and Sofia Tejada and Marie-Capucine Tellier and Fran{\c c}ois T{\'e}oul{\'e} and Pleun Terpstra and Olivier Terrier and Nicolas Terzi and Hubert Tessier-Grenier and Adrian Tey and Anand Thakur and Vincent Thibault and Simon-Djamel Thiberville and Beno{\^i}t Thill and Shaun Thompson and Thomson, {Emma C.} and Thwaites, {Ryan S.} and Paul Tierney and Vadim Tieroshyn and Timashev, {Peter S.} and Jean-Fran{\c c}ois Timsit and Vijayaraghavan, {Bharath Kumar Tirupakuzhi} and No{\'e}mie Tissot and Maria Toki and Kristian Tonby and Marta Torre and Antoni Torres and Margarida Torres and Hernando Torres-Zevallos and Michael Towers and Tony Trapani and Th{\'e}o Treoux and Tromeur, {C. cile} and Ioannis Trontzas and Tiffany Trouillon and Jeanne Truong and Christelle Tual and Sarah Tubiana and Helen Tuite and Jean-Marie Turmel and Turtle, {Lance C. W.} and Pawel Twardowski and Makoto Uchiyama and Udayanga, {P. G. Ishara} and Andrew Udy and Roman Ullrich and Alberto Uribe and Asad Usman and Uyeki, {Timothy M.} and Cristinava Vajdovics and Lu{\'i}s Val-Flores and Am{\'e}lie Valran and {van de Velde}, Stijn and {van den Berge}, Marcel and {van der Palen}, Job and {van der Valk}, Paul and {van der Vekens}, Nicky and {van der Voort}, Peter and {van der Werf}, Sylvie and {van Gulik}, Laura and {van Hattem}, Jarne and {van Netten}, Carolien and {van Veen}, Ilonka and No{\'e}mie Vanel and Henk Vanoverschelde and Pooja Varghese and Charline Vauchy and Aur{\'e}lie Veislinger and Sebastian Vencken and Sara Ventura and Annelies Verbon and James Vickers and Vidal, {Jos{\'e} Ernesto} and Vieira, {C. sar} and Deepak Vijayan and Villanueva, {Joy Ann} and Judit Villar and Pierre-Marc Villeneuve and Andrea Villoldo and Benoit Visseaux and Hannah Visser and Chiara Vitiello and Harald Vonkeman and Fanny Vuotto and Shukeri, {Wan Fadzlina Wan Muhd} and Chih-Hsien Wang and Steve Webb and Jia Wei and Katharina Weil and Sanne Wesselius and West, {T. Eoin} and Murray Wham and Bryan Whelan and Nicole White and Wicky, {Paul Henri} and Aur{\'e}lie Wiedemann and Wijaya, {Surya Otto} and Keith Wille and Suzette Willems and Virginie Williams and Evert-Jan Wils and Yiu, {Ng Wing} and Calvin Wong and Ioannis Xynogalas and Masaki Yamazaki and Yazdan Yazdanpanah and Yelnik, {C. cile} and Stephanie Yerkovich and Toshiki Yokoyama and Hodane Yonis and Obada Yousif and Saptadi Yuliarto and Akram Zaaqoq and Marion Zabbe and Maram Zahran and Maria Zambon and Alberto Zanella and Hiba Zayyad and Alexander Zoufaly and David Zucman",
note = "Funding Information: This work was supported by the UK Foreign, Commonwealth, and Development Office and Wellcome [215091/Z/18/Z] and the Bill & Melinda Gates Foundation [OPP1209135]; CIHR Coronavirus Rapid Research Funding Opportunity OV2170359; Grants from Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 Project 101003589] and European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313]; The Imperial NIHR Biomedical Research Centre; The Cambridge NIHR Biomedical Research Centre; and Endorsed by the Irish Critical Care-Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care-Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12]. This work uses Data/Materials provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The Data/materials used for this research were obtained from ISARIC4C. The COVID-19 Clinical Information Network (CO-CIN) data was collated by ISARIC4C Investigators. Data and Material provision were supported by grants from: the National Institute for Health Research (NIHR; award CO-CIN-01), the Medical Research Council (MRC; Grant MC_PC_19059), and the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE), (Award 200907), Wellcome Trust [Turtle, Lance-fellowship 205228/Z/16/Z], NIHR HPRU in Respiratory Infections at Imperial College London with PHE (Award 200927), Liverpool Experimental Cancer Medicine Centre (Grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (Award IS-BRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. This work was possible due to the dedication and hard work of the Norwegian SARS-CoV-2 study team and supported by grants from Research Council of Norway Grant No. 312780 and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; The dedication and hard work of the Groote Schuur Hospital Covid ICU Team, and supported by the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town; and supported by the COVID clinical management team, AIIMS, Rishikesh, India. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1186/s13054-022-04155-1",
language = "English",
volume = "26",
journal = "Critical care (London, England)",
issn = "1364-8535",
publisher = "Springer Science + Business Media",
number = "1",

}

RIS

TY - JOUR

T1 - Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study

T2 - a prospective, multinational, observational study

AU - Reyes, Luis Felipe

AU - Murthy, Srinivas

AU - Garcia-Gallo, Esteban

AU - Merson, Laura

AU - Ibáñez-Prada, Elsa D.

AU - Rello, Jordi

AU - Fuentes, Yuli V.

AU - Martin-Loeches, Ignacio

AU - Bozza, Fernando

AU - Duque, Sara

AU - Taccone, Fabio S.

AU - Fowler, Robert A.

AU - Kartsonaki, Christiana

AU - Gonçalves, Bronner P.

AU - Citarella, Barbara Wanjiru

AU - Aryal, Diptesh

AU - Burhan, Erlina

AU - Cummings, Matthew J.

AU - Delmas, Christelle

AU - Diaz, Rodrigo

AU - Figueiredo-Mello, Claudia

AU - Hashmi, Madiha

AU - Panda, Prasan Kumar

AU - Jiménez, Miguel Pedrera

AU - Rincon, Diego Fernando Bautista

AU - Thomson, David

AU - Nichol, Alistair

AU - Marshall, John C.

AU - Olliaro, Piero L.

AU - the ISARIC Characterization Group

AU - Abbas, Ali

AU - Abdukahil, Sheryl Ann

AU - Abe, Ryuzo

AU - Abel, Laurent

AU - Absil, Lara

AU - Acharya, Subhash

AU - Acker, Andrew

AU - Adrião, Diana

AU - Al Ageel, Saleh

AU - Ahmed, Shakeel

AU - Ainscough, Kate

AU - Aisa, Tharwat

AU - Hssain, Ali Ait

AU - Tamlihat, Younes Ait

AU - Akimoto, Takako

AU - Akmal, Ernita

AU - Al Qasim, Eman

AU - Alalqam, Razi

AU - Al-dabbous, Tala

AU - Alegesan, Senthilkumar

AU - Alegre, Cynthia

AU - Alessi, Marta

AU - Alex, Beatrice

AU - Alexandre, K. vin

AU - Al-Fares, Abdulrahman

AU - Alfoudri, Huda

AU - Ali, Imran

AU - Shah, Naseem Ali

AU - Alidjnou, Kazali Enagnon

AU - Aliudin, Jeffrey

AU - Alkhafajee, Qabas

AU - Allavena, Clotilde

AU - Allou, Nathalie

AU - Altaf, Aneela

AU - Alves, João

AU - Alves, João Melo

AU - Alves, Rita

AU - Cabrita, Joana Alves

AU - Amaral, Maria

AU - Ampaw, Phoebe

AU - Andini, Roberto

AU - Andréjak, Claire

AU - Angheben, Andrea

AU - Angoulvant, François

AU - Ansart, S. verine

AU - Antonelli, Massimo

AU - de Brito, Carlos Alexandre Antunes

AU - Apriyana, Ardiyan

AU - Arabi, Yaseen

AU - Aragao, Irene

AU - Araujo, Carolline

AU - Arcadipane, Antonio

AU - Archambault, Patrick

AU - Arenz, Lukas

AU - Arlet, Jean-Benoît

AU - Arnold-Day, Christel

AU - Arora, Lovkesh

AU - Arora, Rakesh

AU - Artaud-Macari, Elise

AU - Asensio, Angel

AU - Asif, Namra

AU - Asim, Mohammad

AU - Assie, Jean Baptiste

AU - Atique, Anika

AU - Attanyake, A. M. Udara Lakshan

AU - Auchabie, Johann

AU - Aumaitre, Hugues

AU - Auvet, Adrien

AU - Azemar, Laurène

AU - Azoulay, Cecile

AU - Bach, Benjamin

AU - Bachelet, Delphine

AU - Badr, Claudine

AU - Baig, Nadia

AU - Baillie, J. Kenneth

AU - Bak, Erica

AU - Bakakos, Agamemnon

AU - Bal, Andriy

AU - Balan, Valeria

AU - Bani-Sadr, Firouzé

AU - Barbalho, Renata

AU - Barclay, Wendy S.

AU - Barnikel, Michaela

AU - Barrasa, Helena

AU - Barrelet, Audrey

AU - Barrigoto, Cleide

AU - Bartoli, Marie

AU - Baruch, Joaquín

AU - Basmaci, Romain

AU - Battaglini, Denise

AU - Bauer, Jules

AU - Dow, Denisse Bazan

AU - Beane, Abigail

AU - Bedossa, Alexandra

AU - Begum, Husna

AU - Behilill, Sylvie

AU - Beishuizen, Albertus

AU - Beljantsev, Aleksandr

AU - Bellemare, David

AU - Beltrame, Anna

AU - Beluze, Marine

AU - Benech, Nicolas

AU - Benkerrou, Dehbia

AU - Bennett, Suzanne

AU - Bento, Luís

AU - Berdal, Jan-Erik

AU - Bergeaud, Delphine

AU - Bergin, Hazel

AU - Sobrino, José Luis Bernal

AU - Bertoli, Giulia

AU - Bertolino, Lorenzo

AU - Bessis, Simon

AU - Bevilcaqua, Sybille

AU - Bezulier, Karine

AU - Bhatt, Amar

AU - Bhavsar, Krishna

AU - Bianco, Claudia

AU - Singh, Moirangthem Bikram

AU - Humaid, Felwa Bin

AU - Bissuel, François

AU - Bitker, Laurent

AU - Bitton, Jonathan

AU - Blanco-Schweizer, Pablo

AU - Blier, Catherine

AU - Bloos, Frank

AU - Blot, Mathieu

AU - Boccia, Filomena

AU - Bodenes, Laetitia

AU - Bogaert, Debby

AU - Boivin, Anne-H. lène

AU - Bolze, Pierre-Adrien

AU - Bompart, François

AU - Borges, Diogo

AU - Borie, Raphaël

AU - Bosse, Hans Martin

AU - Botelho-Nevers, Elisabeth

AU - Bouadma, Lila

AU - Bouchaud, Olivier

AU - Bouchez, Sabelline

AU - Bouhmani, Dounia

AU - Bouhour, Damien

AU - Bouiller, K. vin

AU - Bouillet, Laurence

AU - Bouisse, Camile

AU - Boureau, Anne-Sophie

AU - Bourke, John

AU - Bouscambert, Maude

AU - Bousquet, Aurore

AU - Bouziotis, Jason

AU - Boxma, Bianca

AU - Boyer-Besseyre, Marielle

AU - Boylan, Maria

AU - Braconnier, Axelle

AU - Braga, Cynthia

AU - Brandenburger, Timo

AU - Monteiro, Filipa Brás

AU - Brazzi, Luca

AU - Breen, Dorothy

AU - Breen, Patrick

AU - Brickell, Kathy

AU - Browne, Alex

AU - Browne, Shaunagh

AU - Brusse-Keizer, Marjolein

AU - Buchtele, Nina

AU - Buesaquillo, Christian

AU - Bugaeva, Polina

AU - Buisson, Marielle

AU - Burrell, Aidan

AU - Bustos, Ingrid G.

AU - Butnaru, Denis

AU - Cabie, André

AU - Cabral, Susana

AU - Caceres, Eder

AU - Cadoz, Cyril

AU - Garcês, Rui Caetano

AU - Calligy, Kate

AU - Calvache, Jose Andres

AU - Camões, João

AU - Campana, Valentine

AU - Campbell, Paul

AU - Canepa, Cecilia

AU - Cantero, Mireia

AU - Caraux-Paz, Pauline

AU - Cárcel, Sheila

AU - Cardellino, Chiara Simona

AU - Cardoso, Filipa

AU - Cardoso, Filipe

AU - Cardoso, Nelson

AU - Cardoso, Sofia

AU - Carelli, Simone

AU - Carlier, Nicolas

AU - Carmoi, Thierry

AU - Carney, Gayle

AU - Carqueja, Inês

AU - Carret, Marie-Christine

AU - Carrier, François Martin

AU - Carroll, Ida

AU - Carson, Gail

AU - Casanova, Maire-Laure

AU - Cascão, Mariana

AU - Casey, Siobhan

AU - Casimiro, José

AU - Cassandra, Bailey

AU - Castañeda, Silvia

AU - Castanheira, Nidyanara

AU - Castor-Alexandre, Guylaine

AU - Castrillón, Henry

AU - Castro, Ivo

AU - Catarino, Ana

AU - Catherine, François-Xavier

AU - Cattaneo, Paolo

AU - Cavalin, Roberta

AU - Cavalli, Giulio Giovanni

AU - Cavayas, Alexandros

AU - Ceccato, Adrian

AU - Cervantes-Gonzalez, Minerva

AU - Chair, Anissa

AU - Chakveatze, Catherine

AU - Chan, Adrienne

AU - Chand, Meera

AU - Auger, Christelle Chantalat

AU - Chapplain, Jean-Marc

AU - Chas, Julie

AU - Chaudry, Mobin

AU - Iñiguez, Jonathan Samuel Chávez

AU - Chen, Anjellica

AU - Chen, Yih-Sharng

AU - Cheng, Matthew Pellan

AU - Cheret, Antoine

AU - Chiarabini, Thibault

AU - Chica, Julian

AU - Chirouze, Catherine

AU - Chiumello, Davide

AU - Cho, Sung-Min

AU - Cholley, Bernard

AU - Chopin, Marie-Charlotte

AU - Cidade, Jose Pedro

AU - Herreros, José Miguel Cisneros

AU - Ciullo, Anna

AU - Clarke, Emma

AU - Clarke, Jennifer

AU - Clohisey, Sara

AU - Cobb, Perren J.

AU - Codan, Cassidy

AU - Cody, Caitriona

AU - Coelho, Alexandra

AU - Coles, Megan

AU - Colin, Gwenhaël

AU - Collins, Michael

AU - Colombo, Sebastiano Maria

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AU - Foley, Jean

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AU - Fonseca, Tatiana

AU - Fontela, Patricia

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AU - Freire, Marcela Vieira

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AU - Fry, Stéphanie

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AU - Gagnard, Jean-Charles

AU - Gagneux-Brunon, Amandine

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AU - Skeie, Linda Gail

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AU - Gamble, Carrol

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AU - Garcia, Rebekha

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AU - Geraud, Eva

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AU - Giani, Marco

AU - Gibson, Jess

AU - Gigante, Tristan

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AU - Giordano, Guillermo

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AU - Gissot, Valérie

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AU - Goco, Geraldine

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AU - Goffard, Jean-Christophe

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AU - Gómez-Junyent, Joan

AU - Gominet, Marie

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AU - Gorenne, Isabelle

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AU - Goujard, C. cile

AU - Goulenok, Tiphaine

AU - Grable, Margarite

AU - Graf, Jeronimo

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AU - Grasselli, Giacomo

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AU - Greenhalf, William

AU - Greffe, Segolène

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AU - Griffiths, Fiona

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AU - Gu, Yusing

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AU - Guellec, Dewi

AU - Guerguerian, Anne-Marie

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AU - Guilleminault, Laurent

AU - de Castro, Maisa Guimarães

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AU - Haalboom, Marieke

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AU - Habraken, Hannah

AU - Hachemi, Ali

AU - Hadri, Nadir

AU - Haidri, Fakhir

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AU - Hall, Matthew

AU - Halpin, Sophie

AU - Hameed, Jawad

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AU - Hammond, Terese

AU - Haniffa, Rashan

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AU - Harrison, Ewen M.

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AU - Hasan, Mohd Shahnaz

AU - Hashmi, Junaid

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AU - Hayes, Ailbhe

AU - Hays, Leanne

AU - Heerman, Jan

AU - Heggelund, Lars

AU - Hendry, Ross

AU - Hennessy, Martina

AU - Hentzien, Maxime

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AU - Hesstvedt, Liv

AU - Hidayah, Astarini

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AU - Higgins, Eibhilin

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AU - Hinchion, Rita

AU - Hinton, Samuel

AU - Hitoto, Hikombo

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AU - Hoffmann, Isabelle

AU - Hoiting, Oscar

AU - Holt, Rebecca

AU - Holter, Jan Cato

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AU - Horcajada, Juan Pablo

AU - Hoshino, Koji

AU - Hoshino, Kota

AU - Houas, Ikram

AU - Hough, Catherine L.

AU - Hsu, Jimmy Ming-Yang

AU - Hulot, Jean-S. bastien

AU - Huo, Stella

AU - Hurd, Abby

AU - Hussain, Iqbal

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AU - Ikram, Arfan

AU - Illes, Hajnal-Gabriela

AU - Imbert, Patrick

AU - Imran, Mohammad

AU - Sikander, Rana Imran

AU - Imtiaz, Aftab

AU - Inácio, Hugo

AU - Dominguez, Carmen Infante

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AU - Isgett, Sarah

AU - Isidoro, Tiago

AU - Isnard, Margaux

AU - Ivulich, Daniel

AU - Jaafar, Danielle

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AU - Jamieson, Nina

AU - Jaquet, Pierre

AU - Jaud-Fischer, Coline

AU - Jaureguiberry, Stéphane

AU - Jego, Florence

AU - Jenum, Synne

AU - García, Ruth N. Jorge

AU - Joseph, C. dric

AU - Joseph, Mark

AU - Joshi, Swosti

AU - Jourdain, Mercé

AU - Jouvet, Philippe

AU - Jung, Anna

AU - Juzar, Dafsah

AU - Kafif, Ouifiya

AU - Kaguelidou, Florentia

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AU - Kandamby, Darshana Hewa

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AU - Kanwal, Darakhshan

AU - Kataria, Anant

AU - Katz, Kevin

AU - Kay, Christy

AU - Keane, Hannah

AU - Keating, Seán

AU - Kelly, Andrea

AU - Kelly, Aoife

AU - Kelly, Claire

AU - Kelly, Niamh

AU - Kelly, Sadie

AU - Kelly, Yvelynne

AU - Kelsey, Maeve

AU - Kennon, Kalynn

AU - Kernan, Maeve

AU - Kerroumi, Younes

AU - Keshav, Sharma

AU - Khalid, Imrana

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AU - Khalil, Antoine

AU - Khan, Coralie

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AU - Khan, Quratul Ain

AU - Khanal, Sushil

AU - Khatak, Abid

AU - Khawaja, Amin

AU - Kho, Michelle E.

AU - Khoo, Saye

AU - Khoso, Nasir

AU - Kida, Yuri

AU - Kiiza, Peter

AU - Granerud, Beathe Kiland

AU - Kildal, Anders Benjamin

AU - Kimmoun, Antoine

AU - Kindgen-Milles, Detlef

AU - Kitamura, Nobuya

AU - Klenerman, Paul

AU - Klont, Rob

AU - Bekken, Gry Kloumann

AU - Knight, Stephen R.

AU - Kobbe, Robin

AU - Kodippily, Chamira

AU - Vasconcelos, Malte Kohns

AU - Koirala, Sabin

AU - Kosgei, Caroline

AU - Kpangon, Arsène

AU - Krawczyk, Karolina

AU - Kruglova, Oksana

AU - Kumar, Deepali

AU - Kumar, Mukesh

AU - Vijayaraghavan, Bharath Kumar Tirupakuzhi

AU - Vecham, Pavan Kumar

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AU - Kutsogiannis, Demetrios

AU - Kutsyna, Galyna

AU - Kyriakoulis, Konstantinos

AU - Lachatre, Marie

AU - Lacoste, Marie

AU - Laffey, John G.

AU - Lagrange, Marie

AU - Laine, Fabrice

AU - Lairez, Olivier

AU - Lakhey, Sanjay

AU - Lalueza, Antonio

AU - Lambert, Marc

AU - Lamontagne, François

AU - Langelot-Richard, Marie

AU - Langlois, Vincent

AU - Lantang, Eka Yudha

AU - Lanza, Marina

AU - Laouénan, C. dric

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AU - Lasry, Stéphane

AU - Latif, Naveed

AU - Launay, Odile

AU - Laureillard, Didier

AU - Lavie-Badie, Yoan

AU - Law, Andrew

AU - Lawrence, Cassie

AU - Lawrence, Teresa

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AU - le Bris, Cyril

AU - le Falher, Georges

AU - le Fevre, Lucie

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AU - le Maréchal, Marion

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AU - le Nagard, Hervé

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AU - Leal, Ema

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AU - Lee, Jennifer

AU - Lee, Su Hwan

AU - Lee, Todd C.

AU - Leeming, Gary

AU - Lefebvre, B. nédicte

AU - Lefebvre, Laurent

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AU - LeGac, Sylvie

AU - Lelievre, Jean-Daniel

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AU - Lemaignen, Adrien

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AU - León, Rafael

AU - Leone, Marc

AU - Leone, Michela

AU - Lescure, François-Xavier

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AU - Lesouhaitier, Mathieu

AU - Lester-Grant, Amy

AU - Levy, Bruno

AU - Levy, Yves

AU - Levy-Marchal, Claire

AU - Lewandowska, Katarzyna

AU - l’Her, Erwan

AU - Bassi, Gianluigi Li

AU - Liaquat, Ali

AU - Liegeon, Geoffrey

AU - Lim, Wei Shen

AU - Lima, Chantre

AU - Lina, Bruno

AU - Lind, Andreas

AU - Lingas, Guillaume

AU - Lion-Daolio, Sylvie

AU - Liu, Keibun

AU - Livrozet, Marine

AU - Lizotte, Patricia

AU - Loforte, Antonio

AU - Lolong, Navy

AU - Lopes, Diogo

AU - Loschner, Anthony L.

AU - Loubet, Paul

AU - Loufti, Bouchra

AU - Louis, Guillame

AU - Lourenco, Silvia

AU - Lovelace-Macon, Lara

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AU - Lucet, Jean Christophe

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AU - Luna, Carlos M.

AU - Luong, Liem

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AU - Luton, Dominique

AU - Lwin, Nilar

AU - Lyons, Ruth

AU - Maasikas, Olavi

AU - Mabiala, Oryane

AU - Machado, Moïse

AU - Machado, Sara

AU - Macheda, Gabriel

AU - Madiha, Hashmi

AU - de la Calle, Guillermo Maestro

AU - Mahieu, Rafael

AU - Mahy, Sophie

AU - Maia, Ana Raquel

AU - Maier, Lars S.

AU - Maillet, Mylène

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AU - Malfertheiner, Maximilian

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AU - Mallon, Paddy

AU - Maltez, Fernando

AU - Malvy, Denis

AU - Manda, Victoria

AU - Mandelbrot, Laurent

AU - Mankikian, Julie

AU - Manning, Edmund

AU - Manuel, Aldric

AU - Sant, Ceila Maria

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AU - Marino, Daniel

AU - Marino, Flávio

AU - Markowicz, Samuel

AU - Marques, Ana

AU - Marquis, Catherine

AU - Marsh, Brian

AU - Marsh, Laura

AU - Marshal, Megan

AU - Martelli, Celina Turchi

AU - Martin, Emily

AU - Martin-Blondel, Guillaume

AU - Martinot, Martin

AU - Martins, Ana

AU - Martins, João

AU - Martins, Nuno

AU - Rego, Caroline Martins

AU - Martucci, Gennaro

AU - Martynenko, Olga

AU - Marwali, Eva Miranda

AU - Maslove, David

AU - Mason, Sabina

AU - Masood, Sobia

AU - Nor, Basri Mat

AU - Nor, Basri Mat

AU - Matan, Moshe

AU - Mathew, Meghena

AU - Mathieu, Daniel

AU - Mattei, Mathieu

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AU - Maulin, Laurence

AU - Maxwell, Michael

AU - Maynar, Javier

AU - Mazzoni, Thierry

AU - Mc Evoy, Natalie

AU - Mc Sweeney, Lisa

AU - McArthur, Colin

AU - McArthur, Colin

AU - McCarthy, Aine

AU - McCarthy, Anne

AU - McCloskey, Colin

AU - McConnochie, Rachael

AU - McDermott, Sherry

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AU - McElroy, Aine

AU - McElwee, Samuel

AU - McEneany, Victoria

AU - McGeer, Allison

AU - McKay, Chris

AU - McKeown, Johnny

AU - McLean, Kenneth A.

AU - McNally, Paul

AU - McNicholas, Bairbre

AU - McPartlan, Elaine

AU - Meaney, Edel

AU - Mear-Passard, C. cile

AU - Mechlin, Maggie

AU - Atif, Minahel

AU - Meher, Maqsood

AU - Mele, Ferruccio

AU - Melo, Luis

AU - Memon, Kashif

AU - Mendes, Joao Joao

AU - Menkiti, Ogechukwu

AU - Menon, Kusum

AU - Mentré, France

AU - Mentzer, Alexander J.

AU - Mercier, Emmanuelle

AU - Mercier, Noémie

AU - Merckx, Antoine

AU - Mergeay-Fabre, Mayka

AU - Mergler, Blake

AU - Mesquita, António

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AU - Meybeck, Agnès

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AU - Meynert, Alison M.

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AU - Mezidi, Mehdi

AU - Michelanglei, C. line

AU - Michelet, Isabelle

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AU - Molina, David

AU - Molinos, Elena

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AU - Mone, Mary

AU - Monteiro, Agostinho

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AU - Cely, Lina Morales

AU - Moro, Lucia

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AU - Motos, Ana

AU - Mouquet, Hugo

AU - Perrot, Clara Mouton

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AU - Mufti, Aisha Kalsoom

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AU - Müller, Fredrik

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AU - Murphy, Aisling

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AU - Murphy, Lorna

AU - Murris, Marlène

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AU - Myrodia, Dimitra Melia

AU - Mohd-Hanafiah, Farah Nadia

AU - Nagpal, Dave

AU - Nagrebetsky, Alex

AU - Narayanan, Nageswaran

AU - Khan, Rashid Nasim

AU - Nazerali-Maitland, Alasdair

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AU - Nekliudov, Nikita

AU - Neto, Raul

AU - Neumann, Emily

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AU - Nghi, Anthony

AU - Nguyen, Duc

AU - Choileain, Orna Ni

AU - Leathlobhair, Niamh Ni

AU - Nitayavardhana, Prompak

AU - Nonas, Stephanie

AU - Noret, Marion

AU - Norman, Lisa

AU - Notari, Alessandra

AU - Noursadeghi, Mahdad

AU - Nowinski, Adam

AU - Nseir, Saad

AU - Nunez, Jose I.

AU - Nurnaningsih, Nurnaningsih

AU - Nyamankolly, Elsa

AU - Brien, Fionnuala O.

AU - Callaghan, Annmarie O.

AU - O’Callaghan, Annmarie

AU - Occhipinti, Giovanna

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AU - Ogston, Tawnya

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AU - O’Halloran, Sophie

AU - O’Hearn, Katie

AU - Oliveira, João

AU - Oliveira, Larissa

AU - Ong, David S. Y.

AU - Oosthuyzen, Wilna

AU - Opavsky, Anne

AU - Openshaw, Peter

AU - Orakzai, Saijad

AU - Orozco-Chamorro, Claudia Milena

AU - Ortoleva, Jamel

AU - Osatnik, Javier

AU - O’Shea, Linda

AU - O’Sullivan, Miriam

AU - Ouamara, Nadia

AU - Ouissa, Rachida

AU - Oziol, Eric

AU - Pagadoy, Maïder

AU - Pages, Justine

AU - Palacios, Amanda

AU - Palacios, Mario

AU - Palmarini, Massimo

AU - Panarello, Giovanna

AU - Paneru, Hem

AU - Panigada, Mauro

AU - Pansu, Nathalie

AU - Papadopoulos, Aurélie

AU - Parke, Rachael

AU - Parker, Melissa

AU - Parra, Briseida

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AU - Pasquier, J. rémie

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AU - Patauner, Fabian

AU - Patrão, Luís

AU - Patricio, Patricia

AU - Patrier, Juliette

AU - Patterson, Lisa

AU - Pattnaik, Rajyabardhan

AU - Paul, Christelle

AU - Paul, Mical

AU - Paulos, Jorge

AU - Paxton, William A.

AU - Payen, Jean-François

AU - Peelman, Florent

AU - Peiffer-Smadja, Nathan

AU - Peigne, Vincent

AU - Pejkovska, Mare

AU - Pelosi, Paolo

AU - Peltan, Ithan D.

AU - Pereira, Rui

AU - Perez, Daniel

AU - Periel, Luis

AU - Perpoint, Thomas

AU - Pesenti, Antonio

AU - Pestre, Vincent

AU - Petrou, Lenka

AU - Petrovic, Michele

AU - Petrov-Sanchez, Ventzislava

AU - Pettersen, Frank Olav

AU - Peytavin, Gilles

AU - Pharand, Scott

AU - Picard, Walter

AU - Picone, Olivier

AU - Pierobon, Carola

AU - Piersma, Djura

AU - Pimentel, Carlos

AU - Pinto, Raquel

AU - Pires, Catarina

AU - Pironneau, Isabelle

AU - Piroth, Lionel

AU - Pius, Riinu

AU - Plantier, Laurent

AU - Poissy, Julien

AU - Pokeerbux, Ryadh

AU - Poli, Sergio

AU - Pollakis, Georgios

AU - Ponscarme, Diane

AU - Post, Andra-Maris

AU - Postma, Douwe F.

AU - Povoa, Pedro

AU - Póvoas, Diana

AU - Powis, Jeff

AU - Prapa, Sofia

AU - Preau, S. bastien

AU - Prebensen, Christian

AU - Preiser, Jean-Charles

AU - Prinssen, Anton

AU - Pritchard, Mark G.

AU - Priyadarshani, Gamage Dona Dilanthi

AU - Proença, Lucia

AU - Pudota, Sravya

AU - Puéchal, Oriane

AU - Semedi, Bambang Pujo

AU - Pulicken, Mathew

AU - Purcell, Gregory

AU - Quesada, Luisa

AU - Quinones-Cardona, Vilmaris

AU - González, V. ctor Quirós

AU - Quist-Paulsen, Else

AU - Quraishi, Mohammed

AU - Rabaud, Christian

AU - Rabindrarajan, Ebenezer

AU - Rafael, Aldo

AU - Rafiq, Marie

AU - Rahutullah, Arsalan

AU - Rainieri, Fernando

AU - Ramachandran, Pratheema

AU - Ramakrishnan, Nagarajan

AU - Ramalho, José

AU - Rammaert, Blandine

AU - Ramos, Grazielle Viana

AU - Rana, Asim

AU - Rangappa, Rajavardhan

AU - Ranjan, Ritika

AU - Rapp, Christophe

AU - Rashan, Aasiyah

AU - Rashan, Thalha

AU - Rasheed, Ghulam

AU - Rasmin, Menaldi

AU - Rätsep, Indrek

AU - Rau, Cornelius

AU - Raza, Ali

AU - Real, Andre

AU - Rebaudet, Stanislas

AU - Redl, Sarah

AU - Reeve, Brenda

AU - Rehman, Attaur

AU - Reid, Liadain

AU - Reid, Liadain

AU - Reikvam, Dag Henrik

AU - Reis, Renato

AU - Remppis, Jonathan

AU - Remy, Martine

AU - Ren, Hongru

AU - Renk, Hanna

AU - Resseguier, Anne-Sophie

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N1 - Funding Information: This work was supported by the UK Foreign, Commonwealth, and Development Office and Wellcome [215091/Z/18/Z] and the Bill & Melinda Gates Foundation [OPP1209135]; CIHR Coronavirus Rapid Research Funding Opportunity OV2170359; Grants from Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 Project 101003589] and European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313]; The Imperial NIHR Biomedical Research Centre; The Cambridge NIHR Biomedical Research Centre; and Endorsed by the Irish Critical Care-Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care-Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12]. This work uses Data/Materials provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The Data/materials used for this research were obtained from ISARIC4C. The COVID-19 Clinical Information Network (CO-CIN) data was collated by ISARIC4C Investigators. Data and Material provision were supported by grants from: the National Institute for Health Research (NIHR; award CO-CIN-01), the Medical Research Council (MRC; Grant MC_PC_19059), and the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE), (Award 200907), Wellcome Trust [Turtle, Lance-fellowship 205228/Z/16/Z], NIHR HPRU in Respiratory Infections at Imperial College London with PHE (Award 200927), Liverpool Experimental Cancer Medicine Centre (Grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (Award IS-BRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. This work was possible due to the dedication and hard work of the Norwegian SARS-CoV-2 study team and supported by grants from Research Council of Norway Grant No. 312780 and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; The dedication and hard work of the Groote Schuur Hospital Covid ICU Team, and supported by the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town; and supported by the COVID clinical management team, AIIMS, Rishikesh, India. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.

AB - Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.

KW - COVID-19

KW - Critical care

KW - High flow nasal cannula

KW - Invasive mechanical ventilation

UR - http://www.scopus.com/inward/record.url?scp=85137788209&partnerID=8YFLogxK

U2 - 10.1186/s13054-022-04155-1

DO - 10.1186/s13054-022-04155-1

M3 - Article

C2 - 36100904

VL - 26

JO - Critical care (London, England)

JF - Critical care (London, England)

SN - 1364-8535

IS - 1

M1 - 276

ER -

ID: 29721093