Rectal microbiota are coupled with altered cytokine production capacity following community-acquired pneumonia hospitalization

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Rectal microbiota are coupled with altered cytokine production capacity following community-acquired pneumonia hospitalization. / Kullberg, Robert F J ; Brands, Xanthe; Klarenbeek, Augustijn M et al.

In: iScience, Vol. 25, No. 8, 19.08.2022, p. 104740.

Research output: Contribution to journal › Article › Academic › peer-review

BibTeX

@article{f6052726f8644a2aaa4d0eea2eb64b7d,

title = "Rectal microbiota are coupled with altered cytokine production capacity following community-acquired pneumonia hospitalization",

abstract = "Human studies describing the immunomodulatory role of the intestinal microbiota in systemic infections are lacking. Here, we sought to relate microbiota profiles from 115 patients with community-acquired pneumonia (CAP), both on hospital admission and following discharge, to concurrent circulating monocyte and neutrophil function. Rectal microbiota composition did not explain variation in cytokine responses in acute CAP (median 0%, IQR 0.0%-1.9%), but did one month following hospitalization (median 4.1%, IQR 0.0%-6.6%, p = 0.0035). Gene expression analysis of monocytes showed that undisrupted microbiota profiles following hospitalization were associated with upregulated interferon, interleukin-10, and G-protein-coupled-receptor-ligand-binding pathways. While CAP is characterized by profoundly distorted gut microbiota, the effects of these disruptions on cytokine responses and transcriptional profiles during acute infection were absent or modest. However, rectal microbiota were related to altered cytokine responses one month following CAP hospitalization, which may provide insights into potential mechanisms contributing to the high risk of recurrent infections following hospitalization.",

author = "Kullberg, {Robert F J} and Xanthe Brands and Klarenbeek, {Augustijn M} and Butler, {Joe M} and Otto, {Natasja A} and Faber, {Dani{\"e}l R} and Scicluna, {Brendon P} and {van der Poll}, Tom and Wiersinga, {W Joost} and Haak, {Bastiaan W}",

note = "{\textcopyright} 2022 The Author(s).",

year = "2022",

month = aug,

day = "19",

doi = "10.1016/j.isci.2022.104740",

language = "English",

volume = "25",

pages = "104740",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier Inc.",

number = "8",

}

RIS

TY - JOUR

T1 - Rectal microbiota are coupled with altered cytokine production capacity following community-acquired pneumonia hospitalization

AU - Kullberg, Robert F J

AU - Brands, Xanthe

AU - Klarenbeek, Augustijn M

AU - Butler, Joe M

AU - Otto, Natasja A

AU - Faber, Daniël R

AU - Scicluna, Brendon P

AU - van der Poll, Tom

AU - Wiersinga, W Joost

AU - Haak, Bastiaan W

PY - 2022/8/19

Y1 - 2022/8/19

N2 - Human studies describing the immunomodulatory role of the intestinal microbiota in systemic infections are lacking. Here, we sought to relate microbiota profiles from 115 patients with community-acquired pneumonia (CAP), both on hospital admission and following discharge, to concurrent circulating monocyte and neutrophil function. Rectal microbiota composition did not explain variation in cytokine responses in acute CAP (median 0%, IQR 0.0%-1.9%), but did one month following hospitalization (median 4.1%, IQR 0.0%-6.6%, p = 0.0035). Gene expression analysis of monocytes showed that undisrupted microbiota profiles following hospitalization were associated with upregulated interferon, interleukin-10, and G-protein-coupled-receptor-ligand-binding pathways. While CAP is characterized by profoundly distorted gut microbiota, the effects of these disruptions on cytokine responses and transcriptional profiles during acute infection were absent or modest. However, rectal microbiota were related to altered cytokine responses one month following CAP hospitalization, which may provide insights into potential mechanisms contributing to the high risk of recurrent infections following hospitalization.

AB - Human studies describing the immunomodulatory role of the intestinal microbiota in systemic infections are lacking. Here, we sought to relate microbiota profiles from 115 patients with community-acquired pneumonia (CAP), both on hospital admission and following discharge, to concurrent circulating monocyte and neutrophil function. Rectal microbiota composition did not explain variation in cytokine responses in acute CAP (median 0%, IQR 0.0%-1.9%), but did one month following hospitalization (median 4.1%, IQR 0.0%-6.6%, p = 0.0035). Gene expression analysis of monocytes showed that undisrupted microbiota profiles following hospitalization were associated with upregulated interferon, interleukin-10, and G-protein-coupled-receptor-ligand-binding pathways. While CAP is characterized by profoundly distorted gut microbiota, the effects of these disruptions on cytokine responses and transcriptional profiles during acute infection were absent or modest. However, rectal microbiota were related to altered cytokine responses one month following CAP hospitalization, which may provide insights into potential mechanisms contributing to the high risk of recurrent infections following hospitalization.

U2 - 10.1016/j.isci.2022.104740

DO - 10.1016/j.isci.2022.104740

M3 - Article

C2 - 35938048

VL - 25

SP - 104740

JO - iScience

JF - iScience

SN - 2589-0042

IS - 8

ER -

ID: 31247851

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