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Quantitative Fluorescence Imaging of Perfusion—An Algorithm to Predict Anastomotic Leakage. / Jansen, Sanne M.; de Bruin, Daniel M.; Wilk, Leah S. et al.

In: Life (Basel, Switzerland), Vol. 12, No. 2, 249, 01.02.2022.

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@article{88850730d634464a9074d2351860a815,
title = "Quantitative Fluorescence Imaging of Perfusion—An Algorithm to Predict Anastomotic Leakage",
abstract = "This study tests fluorescence imaging-derived quantitative parameters for perfusion evaluation of the gastric tube during surgery and correlates these parameters with patient outcomes in terms of anastomotic leakage. Poor fundus perfusion is seen as a major factor for the development of anastomotic leakage and strictures. Fluorescence perfusion imaging may reduce the incidence of complications. Parameters for the quantification of the fluorescence signal are still lacking. Quantitative parameters in terms of maximal intensity, mean slope and influx timepoint were tested for significant differences between four perfusion areas of the gastric tube in 22 patients with a repeated ANOVA test. These parameters were compared with patient outcomes. Maximal intensity, mean slope and influx timepoint were significantly different between the base of the gastric tube and the fundus (p < 0.0001). Patients who developed anastomotic leakage showed a mean slope of almost 0 in Location 4. The distance of the demarcation of ICG to the fundus was significantly higher in the three patients who developed anastomotic leakage (p < 0.0001). This study presents quantitative intra-operative perfusion imaging with fluorescence. Quantification of the fluorescence signal allows for early risk stratification of necrosis.",
keywords = "Anastomosis, Fluorescence imaging, Parameters, Perfusion, Surgery",
author = "Jansen, {Sanne M.} and {de Bruin}, {Daniel M.} and Wilk, {Leah S.} and {van Berge Henegouwen}, {Mark I.} and Strackee, {Simon D.} and Gisbertz, {Suzanne S.} and {van Bavel}, {Ed T.} and {van Leeuwen}, {Ton G.}",
note = "Funding Information: Source of funding: ZonMW WBS W.001775. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = feb,
day = "1",
doi = "10.3390/life12020249",
language = "English",
volume = "12",
journal = "Life (Basel, Switzerland)",
issn = "2075-1729",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

RIS

TY - JOUR

T1 - Quantitative Fluorescence Imaging of Perfusion—An Algorithm to Predict Anastomotic Leakage

AU - Jansen, Sanne M.

AU - de Bruin, Daniel M.

AU - Wilk, Leah S.

AU - van Berge Henegouwen, Mark I.

AU - Strackee, Simon D.

AU - Gisbertz, Suzanne S.

AU - van Bavel, Ed T.

AU - van Leeuwen, Ton G.

N1 - Funding Information: Source of funding: ZonMW WBS W.001775. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - This study tests fluorescence imaging-derived quantitative parameters for perfusion evaluation of the gastric tube during surgery and correlates these parameters with patient outcomes in terms of anastomotic leakage. Poor fundus perfusion is seen as a major factor for the development of anastomotic leakage and strictures. Fluorescence perfusion imaging may reduce the incidence of complications. Parameters for the quantification of the fluorescence signal are still lacking. Quantitative parameters in terms of maximal intensity, mean slope and influx timepoint were tested for significant differences between four perfusion areas of the gastric tube in 22 patients with a repeated ANOVA test. These parameters were compared with patient outcomes. Maximal intensity, mean slope and influx timepoint were significantly different between the base of the gastric tube and the fundus (p < 0.0001). Patients who developed anastomotic leakage showed a mean slope of almost 0 in Location 4. The distance of the demarcation of ICG to the fundus was significantly higher in the three patients who developed anastomotic leakage (p < 0.0001). This study presents quantitative intra-operative perfusion imaging with fluorescence. Quantification of the fluorescence signal allows for early risk stratification of necrosis.

AB - This study tests fluorescence imaging-derived quantitative parameters for perfusion evaluation of the gastric tube during surgery and correlates these parameters with patient outcomes in terms of anastomotic leakage. Poor fundus perfusion is seen as a major factor for the development of anastomotic leakage and strictures. Fluorescence perfusion imaging may reduce the incidence of complications. Parameters for the quantification of the fluorescence signal are still lacking. Quantitative parameters in terms of maximal intensity, mean slope and influx timepoint were tested for significant differences between four perfusion areas of the gastric tube in 22 patients with a repeated ANOVA test. These parameters were compared with patient outcomes. Maximal intensity, mean slope and influx timepoint were significantly different between the base of the gastric tube and the fundus (p < 0.0001). Patients who developed anastomotic leakage showed a mean slope of almost 0 in Location 4. The distance of the demarcation of ICG to the fundus was significantly higher in the three patients who developed anastomotic leakage (p < 0.0001). This study presents quantitative intra-operative perfusion imaging with fluorescence. Quantification of the fluorescence signal allows for early risk stratification of necrosis.

KW - Anastomosis

KW - Fluorescence imaging

KW - Parameters

KW - Perfusion

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=85124412409&partnerID=8YFLogxK

U2 - 10.3390/life12020249

DO - 10.3390/life12020249

M3 - Article

C2 - 35207536

VL - 12

JO - Life (Basel, Switzerland)

JF - Life (Basel, Switzerland)

SN - 2075-1729

IS - 2

M1 - 249

ER -

ID: 21866646