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qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients. / on behalf of the MR CLEAN Registry Investigators ; Prasetya, Haryadi; Ramos, Lucas A.; Epema, Thabiso; Treurniet, Kilian M.; Emmer, Bart J.; van den Wijngaard, Ido R.; Zhang, Guang; Kappelhof, Manon; Berkhemer, Olvert A.; Yoo, Albert J.; Roos, Yvo B. EW. M.; van Oostenbrugge, Robert J.; Dippel, Diederik W. J.; van Zwam, Wim H.; van der Lugt, Aad; de Mol, Bas A. JM; Majoie, Charles B. LM; Bavel, Ed van; Marquering, Henk A.

In: International journal of stroke, Vol. 16, No. 2, 02.2021, p. 207-216.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

on behalf of the MR CLEAN Registry Investigators, Prasetya, H, Ramos, LA, Epema, T, Treurniet, KM, Emmer, BJ, van den Wijngaard, IR, Zhang, G, Kappelhof, M, Berkhemer, OA, Yoo, AJ, Roos, YBEWM, van Oostenbrugge, RJ, Dippel, DWJ, van Zwam, WH, van der Lugt, A, de Mol, BAJM, Majoie, CBLM, Bavel, EV & Marquering, HA 2021, 'qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients', International journal of stroke, vol. 16, no. 2, pp. 207-216. https://doi.org/10.1177/1747493020909632

APA

on behalf of the MR CLEAN Registry Investigators, Prasetya, H., Ramos, L. A., Epema, T., Treurniet, K. M., Emmer, B. J., van den Wijngaard, I. R., Zhang, G., Kappelhof, M., Berkhemer, O. A., Yoo, A. J., Roos, Y. B. EW. M., van Oostenbrugge, R. J., Dippel, D. W. J., van Zwam, W. H., van der Lugt, A., de Mol, B. A. JM., Majoie, C. B. LM., Bavel, E. V., & Marquering, H. A. (2021). qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients. International journal of stroke, 16(2), 207-216. https://doi.org/10.1177/1747493020909632

Vancouver

Author

on behalf of the MR CLEAN Registry Investigators ; Prasetya, Haryadi ; Ramos, Lucas A. ; Epema, Thabiso ; Treurniet, Kilian M. ; Emmer, Bart J. ; van den Wijngaard, Ido R. ; Zhang, Guang ; Kappelhof, Manon ; Berkhemer, Olvert A. ; Yoo, Albert J. ; Roos, Yvo B. EW. M. ; van Oostenbrugge, Robert J. ; Dippel, Diederik W. J. ; van Zwam, Wim H. ; van der Lugt, Aad ; de Mol, Bas A. JM ; Majoie, Charles B. LM ; Bavel, Ed van ; Marquering, Henk A. / qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients. In: International journal of stroke. 2021 ; Vol. 16, No. 2. pp. 207-216.

BibTeX

@article{18571d62213c4fc5b3e214da98bdec52,
title = "qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients",
abstract = "Background: The Thrombolysis in Cerebral Infarction (TICI) scale is an important outcome measure to evaluate the quality of endovascular stroke therapy. The TICI scale is ordinal and observer-dependent, which may result in suboptimal prediction of patient outcome and inconsistent reperfusion grading. Aims: We present a semi-automated quantitative reperfusion measure (quantified TICI (qTICI)) using image processing techniques based on the TICI methodology. Methods: We included patients with an intracranial proximal large vessel occlusion with complete, good quality runs of anteroposterior and lateral digital subtraction angiography from the MR CLEAN Registry. For each vessel occlusion, we identified the target downstream territory and automatically segmented the reperfused area in the target downstream territory on final digital subtraction angiography. qTICI was defined as the percentage of reperfused area in target downstream territory. The value of qTICI and extended TICI (eTICI) in predicting favorable functional outcome (modified Rankin Scale 0–2) was compared using area under receiver operating characteristics curve and binary logistic regression analysis unadjusted and adjusted for known prognostic factors. Results: In total, 408 patients with M1 or internal carotid artery occlusion were included. The median qTICI was 78 (interquartile range 58–88) and 215 patients (53%) had an eTICI of 2C or higher. qTICI was comparable to eTICI in predicting favorable outcome with area under receiver operating characteristics curve of 0.63 vs. 0.62 (P = 0.8) and 0.87 vs. 0.86 (P = 0.87), for the unadjusted and adjusted analysis, respectively. In the adjusted regression analyses, both qTICI and eTICI were independently associated with functional outcome. Conclusion: qTICI provides a quantitative measure of reperfusion with similar prognostic value for functional outcome to eTICI score.",
keywords = "Digital subtraction angiography, endovascular therapy, ischemic stroke, reperfusion",
author = "{on behalf of the MR CLEAN Registry Investigators} and Haryadi Prasetya and Ramos, {Lucas A.} and Thabiso Epema and Treurniet, {Kilian M.} and Emmer, {Bart J.} and {van den Wijngaard}, {Ido R.} and Guang Zhang and Manon Kappelhof and Berkhemer, {Olvert A.} and Yoo, {Albert J.} and Roos, {Yvo B. EW. M.} and {van Oostenbrugge}, {Robert J.} and Dippel, {Diederik W. J.} and {van Zwam}, {Wim H.} and {van der Lugt}, Aad and {de Mol}, {Bas A. JM} and Majoie, {Charles B. LM} and Bavel, {Ed van} and Marquering, {Henk A.}",
note = "Funding Information: qTICI provides a quantitative measure of reperfusion with similar prognostic value for functional outcome to eTICI score. Digital subtraction angiography reperfusion ischemic stroke endovascular therapy Indonesia Endowment Fund for Education (LPDP), Ministry of Finance, Republic of Indonesia LPDP scholarship Program for Doctorate Students edited-state corrected-proof typesetter ts2 Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Indonesia Endowment Fund for Education (LPDP), Ministry of Finance, Republic of Indonesia. Publisher Copyright: {\textcopyright} 2020 World Stroke Organization. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
doi = "10.1177/1747493020909632",
language = "English",
volume = "16",
pages = "207--216",
journal = "International journal of stroke",
issn = "1747-4930",
publisher = "SAGE Publications Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - qTICI: Quantitative assessment of brain tissue reperfusion on digital subtraction angiograms of acute ischemic stroke patients

AU - on behalf of the MR CLEAN Registry Investigators

AU - Prasetya, Haryadi

AU - Ramos, Lucas A.

AU - Epema, Thabiso

AU - Treurniet, Kilian M.

AU - Emmer, Bart J.

AU - van den Wijngaard, Ido R.

AU - Zhang, Guang

AU - Kappelhof, Manon

AU - Berkhemer, Olvert A.

AU - Yoo, Albert J.

AU - Roos, Yvo B. EW. M.

AU - van Oostenbrugge, Robert J.

AU - Dippel, Diederik W. J.

AU - van Zwam, Wim H.

AU - van der Lugt, Aad

AU - de Mol, Bas A. JM

AU - Majoie, Charles B. LM

AU - Bavel, Ed van

AU - Marquering, Henk A.

N1 - Funding Information: qTICI provides a quantitative measure of reperfusion with similar prognostic value for functional outcome to eTICI score. Digital subtraction angiography reperfusion ischemic stroke endovascular therapy Indonesia Endowment Fund for Education (LPDP), Ministry of Finance, Republic of Indonesia LPDP scholarship Program for Doctorate Students edited-state corrected-proof typesetter ts2 Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Indonesia Endowment Fund for Education (LPDP), Ministry of Finance, Republic of Indonesia. Publisher Copyright: © 2020 World Stroke Organization. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - Background: The Thrombolysis in Cerebral Infarction (TICI) scale is an important outcome measure to evaluate the quality of endovascular stroke therapy. The TICI scale is ordinal and observer-dependent, which may result in suboptimal prediction of patient outcome and inconsistent reperfusion grading. Aims: We present a semi-automated quantitative reperfusion measure (quantified TICI (qTICI)) using image processing techniques based on the TICI methodology. Methods: We included patients with an intracranial proximal large vessel occlusion with complete, good quality runs of anteroposterior and lateral digital subtraction angiography from the MR CLEAN Registry. For each vessel occlusion, we identified the target downstream territory and automatically segmented the reperfused area in the target downstream territory on final digital subtraction angiography. qTICI was defined as the percentage of reperfused area in target downstream territory. The value of qTICI and extended TICI (eTICI) in predicting favorable functional outcome (modified Rankin Scale 0–2) was compared using area under receiver operating characteristics curve and binary logistic regression analysis unadjusted and adjusted for known prognostic factors. Results: In total, 408 patients with M1 or internal carotid artery occlusion were included. The median qTICI was 78 (interquartile range 58–88) and 215 patients (53%) had an eTICI of 2C or higher. qTICI was comparable to eTICI in predicting favorable outcome with area under receiver operating characteristics curve of 0.63 vs. 0.62 (P = 0.8) and 0.87 vs. 0.86 (P = 0.87), for the unadjusted and adjusted analysis, respectively. In the adjusted regression analyses, both qTICI and eTICI were independently associated with functional outcome. Conclusion: qTICI provides a quantitative measure of reperfusion with similar prognostic value for functional outcome to eTICI score.

AB - Background: The Thrombolysis in Cerebral Infarction (TICI) scale is an important outcome measure to evaluate the quality of endovascular stroke therapy. The TICI scale is ordinal and observer-dependent, which may result in suboptimal prediction of patient outcome and inconsistent reperfusion grading. Aims: We present a semi-automated quantitative reperfusion measure (quantified TICI (qTICI)) using image processing techniques based on the TICI methodology. Methods: We included patients with an intracranial proximal large vessel occlusion with complete, good quality runs of anteroposterior and lateral digital subtraction angiography from the MR CLEAN Registry. For each vessel occlusion, we identified the target downstream territory and automatically segmented the reperfused area in the target downstream territory on final digital subtraction angiography. qTICI was defined as the percentage of reperfused area in target downstream territory. The value of qTICI and extended TICI (eTICI) in predicting favorable functional outcome (modified Rankin Scale 0–2) was compared using area under receiver operating characteristics curve and binary logistic regression analysis unadjusted and adjusted for known prognostic factors. Results: In total, 408 patients with M1 or internal carotid artery occlusion were included. The median qTICI was 78 (interquartile range 58–88) and 215 patients (53%) had an eTICI of 2C or higher. qTICI was comparable to eTICI in predicting favorable outcome with area under receiver operating characteristics curve of 0.63 vs. 0.62 (P = 0.8) and 0.87 vs. 0.86 (P = 0.87), for the unadjusted and adjusted analysis, respectively. In the adjusted regression analyses, both qTICI and eTICI were independently associated with functional outcome. Conclusion: qTICI provides a quantitative measure of reperfusion with similar prognostic value for functional outcome to eTICI score.

KW - Digital subtraction angiography

KW - endovascular therapy

KW - ischemic stroke

KW - reperfusion

UR - http://www.scopus.com/inward/record.url?scp=85081537650&partnerID=8YFLogxK

U2 - 10.1177/1747493020909632

DO - 10.1177/1747493020909632

M3 - Article

C2 - 32098584

VL - 16

SP - 207

EP - 216

JO - International journal of stroke

JF - International journal of stroke

SN - 1747-4930

IS - 2

ER -

ID: 11241121