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Primary tumour immune response and lymph node yields in colon cancer. / Lal, Nikhil; Chan, Dedrick Kok Hong; Ng, Minn E.; Vermeulen, Louis; Buczacki, Simon James Alexander.

In: British journal of cancer, Vol. 126, No. 8, 03.05.2022, p. 1178-1185.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Lal, N, Chan, DKH, Ng, ME, Vermeulen, L & Buczacki, SJA 2022, 'Primary tumour immune response and lymph node yields in colon cancer', British journal of cancer, vol. 126, no. 8, pp. 1178-1185. https://doi.org/10.1038/s41416-022-01700-1

APA

Lal, N., Chan, D. K. H., Ng, M. E., Vermeulen, L., & Buczacki, S. J. A. (2022). Primary tumour immune response and lymph node yields in colon cancer. British journal of cancer, 126(8), 1178-1185. https://doi.org/10.1038/s41416-022-01700-1

Vancouver

Lal N, Chan DKH, Ng ME, Vermeulen L, Buczacki SJA. Primary tumour immune response and lymph node yields in colon cancer. British journal of cancer. 2022 May 3;126(8):1178-1185. https://doi.org/10.1038/s41416-022-01700-1

Author

Lal, Nikhil ; Chan, Dedrick Kok Hong ; Ng, Minn E. ; Vermeulen, Louis ; Buczacki, Simon James Alexander. / Primary tumour immune response and lymph node yields in colon cancer. In: British journal of cancer. 2022 ; Vol. 126, No. 8. pp. 1178-1185.

BibTeX

@article{13441fa5a808463faf59bf3f1f9b60cd,
title = "Primary tumour immune response and lymph node yields in colon cancer",
abstract = "Background: The mechanism underlying improved survival in non-metastatic colon cancer with higher lymph node (LN) yield is unknown. This study aimed to identify whether molecular features in the primary tumour were predictive of LN yield. Methods: Clinical, genomic, transcriptomic, proteomic and methylation data of non-metastatic, colon cancers studied in The Cancer Genome Atlas were interrogated for associations with LN yield. Based on maximal survival effects, patients were segregated into high (>15) and low (≤15) LN yield. Gene set enrichment analysis was performed on transcriptomic changes to identify biological processes associated with LN yield. Correlations were validated in an independent set of Stage II colon cancers. Results: High LN yield was found predictive of overall and disease-free survival. There was no association of higher LN yield and increasing nodal positivity. High LN yield was strongly linked with gene expression changes associated with the adaptive and dendritic cell immune response. This association was most prominent in node-negative cancers. Analogous findings were reproduced in the validation dataset. Conclusion: The study shows a strong association of an activated immune response in tumours with a high LN yield. Immunogenic tumours have a better prognosis, likely explaining the survival benefit with higher LN yields.",
author = "Nikhil Lal and Chan, {Dedrick Kok Hong} and Ng, {Minn E.} and Louis Vermeulen and Buczacki, {Simon James Alexander}",
note = "Funding Information: Dr. Raza Ali (CRUK CI) for immunological insight and advice on reference datasets. Funding Information: SJAB: The Pharsalia Trust, UK & Cancer Research UK Advanced Clinician Scientist Fellowship (C14094/A27178). DKHC: Singapore Ministry of Health{\textquoteright}s National Medical Research Council under a research training fellowship (MOH-FLWSHP10may-0001). LV: New York Stem Cell Foundation—Robertson Investigator. The study sponsors play no roles in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; or the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = may,
day = "3",
doi = "10.1038/s41416-022-01700-1",
language = "English",
volume = "126",
pages = "1178--1185",
journal = "British journal of cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Primary tumour immune response and lymph node yields in colon cancer

AU - Lal, Nikhil

AU - Chan, Dedrick Kok Hong

AU - Ng, Minn E.

AU - Vermeulen, Louis

AU - Buczacki, Simon James Alexander

N1 - Funding Information: Dr. Raza Ali (CRUK CI) for immunological insight and advice on reference datasets. Funding Information: SJAB: The Pharsalia Trust, UK & Cancer Research UK Advanced Clinician Scientist Fellowship (C14094/A27178). DKHC: Singapore Ministry of Health’s National Medical Research Council under a research training fellowship (MOH-FLWSHP10may-0001). LV: New York Stem Cell Foundation—Robertson Investigator. The study sponsors play no roles in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; or the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s).

PY - 2022/5/3

Y1 - 2022/5/3

N2 - Background: The mechanism underlying improved survival in non-metastatic colon cancer with higher lymph node (LN) yield is unknown. This study aimed to identify whether molecular features in the primary tumour were predictive of LN yield. Methods: Clinical, genomic, transcriptomic, proteomic and methylation data of non-metastatic, colon cancers studied in The Cancer Genome Atlas were interrogated for associations with LN yield. Based on maximal survival effects, patients were segregated into high (>15) and low (≤15) LN yield. Gene set enrichment analysis was performed on transcriptomic changes to identify biological processes associated with LN yield. Correlations were validated in an independent set of Stage II colon cancers. Results: High LN yield was found predictive of overall and disease-free survival. There was no association of higher LN yield and increasing nodal positivity. High LN yield was strongly linked with gene expression changes associated with the adaptive and dendritic cell immune response. This association was most prominent in node-negative cancers. Analogous findings were reproduced in the validation dataset. Conclusion: The study shows a strong association of an activated immune response in tumours with a high LN yield. Immunogenic tumours have a better prognosis, likely explaining the survival benefit with higher LN yields.

AB - Background: The mechanism underlying improved survival in non-metastatic colon cancer with higher lymph node (LN) yield is unknown. This study aimed to identify whether molecular features in the primary tumour were predictive of LN yield. Methods: Clinical, genomic, transcriptomic, proteomic and methylation data of non-metastatic, colon cancers studied in The Cancer Genome Atlas were interrogated for associations with LN yield. Based on maximal survival effects, patients were segregated into high (>15) and low (≤15) LN yield. Gene set enrichment analysis was performed on transcriptomic changes to identify biological processes associated with LN yield. Correlations were validated in an independent set of Stage II colon cancers. Results: High LN yield was found predictive of overall and disease-free survival. There was no association of higher LN yield and increasing nodal positivity. High LN yield was strongly linked with gene expression changes associated with the adaptive and dendritic cell immune response. This association was most prominent in node-negative cancers. Analogous findings were reproduced in the validation dataset. Conclusion: The study shows a strong association of an activated immune response in tumours with a high LN yield. Immunogenic tumours have a better prognosis, likely explaining the survival benefit with higher LN yields.

UR - http://www.scopus.com/inward/record.url?scp=85122867898&partnerID=8YFLogxK

U2 - 10.1038/s41416-022-01700-1

DO - 10.1038/s41416-022-01700-1

M3 - Article

C2 - 35043009

VL - 126

SP - 1178

EP - 1185

JO - British journal of cancer

JF - British journal of cancer

SN - 0007-0920

IS - 8

ER -

ID: 21307522