Research output: Contribution to journal › Article › Academic › peer-review
Population-based study of treatment and outcome of recurrent oesophageal or junctional cancer. / Pape, Marieke; Vissers, Pauline A. J.; Bertwistle, David et al.
In: The British journal of surgery, Vol. 109, No. 12, 22.11.2022, p. 1264-1273.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Population-based study of treatment and outcome of recurrent oesophageal or junctional cancer
AU - Pape, Marieke
AU - Vissers, Pauline A. J.
AU - Bertwistle, David
AU - McDonald, Laura
AU - Beerepoot, Laurens V.
AU - van Berge Henegouwen, Mark I.
AU - Lagarde, Sjoerd M.
AU - Mook, Stella
AU - Mohammad, Nadia Haj
AU - Jeene, Paul M.
AU - van Laarhoven, Hanneke W. M.
AU - Verhoeven, Rob H. A.
N1 - Publisher Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of BJS Society Ltd.
PY - 2022/11/22
Y1 - 2022/11/22
N2 - BACKGROUND: Patients with cancer of the oesophagus or gastro-oesophageal junction have a high risk of recurrence after treatment with curative intent. The aim of this study was to analyse the site of recurrence, treatment, and survival in patients with recurrent disease. METHODS: Patients with non-metastatic oesophageal or junctional carcinoma treated with curative intent between January 2015 and December 2016 were selected from the Netherlands Cancer Registry. Data on recurrence were collected in the second half of 2019. Overall survival (OS) was assessed by Kaplan-Meier methods. RESULTS: In total, 862 of 1909 patients (45.2 per cent) for whom information on follow-up was available had disease recurrence, and 858 patients were included. Some 161 of 858 patients (18.8 per cent) had locoregional recurrence only, 415 (48.4 per cent) had distant recurrence only, and 282 (32.9 per cent) had combined locoregional and distant recurrence. In all, 518 of 858 patients (60.4 per cent) received best supportive care only and 315 (39.6 per cent) underwent tumour-directed therapy. Patients with locoregional recurrence alone more often received chemoradiotherapy than those with distant or combined locoregional and distant recurrence (19.3 per cent versus 0.7 and 2.8 per cent), and less often received systemic therapy (11.2 per cent versus 30.1 and 35.8 per cent). Median OS was 7.6, 4.2, and 3.3 months for patients with locoregional, distant, and combined locoregional and distant recurrence respectively (P < 0.001). CONCLUSION: Disease recurred after curative treatment in 45.2 per cent of patients. Locoregional recurrence developed in only 18.8 per cent. The vast majority of patients presented with distant or combined locoregional and distant recurrence, and received best supportive care.
AB - BACKGROUND: Patients with cancer of the oesophagus or gastro-oesophageal junction have a high risk of recurrence after treatment with curative intent. The aim of this study was to analyse the site of recurrence, treatment, and survival in patients with recurrent disease. METHODS: Patients with non-metastatic oesophageal or junctional carcinoma treated with curative intent between January 2015 and December 2016 were selected from the Netherlands Cancer Registry. Data on recurrence were collected in the second half of 2019. Overall survival (OS) was assessed by Kaplan-Meier methods. RESULTS: In total, 862 of 1909 patients (45.2 per cent) for whom information on follow-up was available had disease recurrence, and 858 patients were included. Some 161 of 858 patients (18.8 per cent) had locoregional recurrence only, 415 (48.4 per cent) had distant recurrence only, and 282 (32.9 per cent) had combined locoregional and distant recurrence. In all, 518 of 858 patients (60.4 per cent) received best supportive care only and 315 (39.6 per cent) underwent tumour-directed therapy. Patients with locoregional recurrence alone more often received chemoradiotherapy than those with distant or combined locoregional and distant recurrence (19.3 per cent versus 0.7 and 2.8 per cent), and less often received systemic therapy (11.2 per cent versus 30.1 and 35.8 per cent). Median OS was 7.6, 4.2, and 3.3 months for patients with locoregional, distant, and combined locoregional and distant recurrence respectively (P < 0.001). CONCLUSION: Disease recurred after curative treatment in 45.2 per cent of patients. Locoregional recurrence developed in only 18.8 per cent. The vast majority of patients presented with distant or combined locoregional and distant recurrence, and received best supportive care.
UR - http://www.scopus.com/inward/record.url?scp=85145129762&partnerID=8YFLogxK
U2 - 10.1093/bjs/znac290
DO - 10.1093/bjs/znac290
M3 - Article
C2 - 35998093
VL - 109
SP - 1264
EP - 1273
JO - British journal of surgery
JF - British journal of surgery
SN - 0007-1323
IS - 12
ER -
ID: 30455021