Research output: Contribution to journal › Article › Academic › peer-review
Outcome and Predictors for Mortality in Patients with Cardiogenic Shock : A Dutch Nationwide Registry-Based Study of 75,407 Patients with Acute Coronary Syndrome Treated by PCI. / Karami, Mina; Peters, Elma J; Lagrand, Wim K et al.
In: Journal of clinical medicine, Vol. 10, No. 10, 11.05.2021.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Outcome and Predictors for Mortality in Patients with Cardiogenic Shock
T2 - A Dutch Nationwide Registry-Based Study of 75,407 Patients with Acute Coronary Syndrome Treated by PCI
AU - Karami, Mina
AU - Peters, Elma J
AU - Lagrand, Wim K
AU - Houterman, Saskia
AU - den Uil, Corstiaan A
AU - Engström, Annemarie E
AU - Otterspoor, Luuk C
AU - Ottevanger, Jan Paul
AU - Ferreira, Irlando A
AU - Montero-Cabezas, Jose M
AU - Sjauw, Krischan
AU - van Ramshorst, Jan
AU - Kraaijeveld, Adriaan O
AU - Verouden, Niels J W
AU - Lipsic, Erik
AU - Vlaar, Alexander P
AU - Henriques, Jose P S
AU - On Behalf Of The Pci Registration Committee Of The Netherlands Heart Registration, null
PY - 2021/5/11
Y1 - 2021/5/11
N2 - It is important to gain more insight into the cardiogenic shock (CS) population, as currently, little is known on how to improve outcomes. Therefore, we assessed clinical outcome in acute coronary syndrome (ACS) patients treated by percutaneous coronary intervention (PCI) with and without CS at admission. Furthermore, the incidence of CS and predictors for mortality in CS patients were evaluated. The Netherlands Heart Registration (NHR) is a nationwide registry on all cardiac interventions. We used NHR data of ACS patients treated with PCI between 2015 and 2019. Among 75,407 ACS patients treated with PCI, 3028 patients (4.1%) were identified with CS, respectively 4.3%, 3.9%, 3.5%, and 4.3% per year. Factors associated with mortality in CS were age (HR 1.02, 95%CI 1.02-1.03), eGFR (HR 0.98, 95%CI 0.98-0.99), diabetes mellitus (DM) (HR 1.25, 95%CI 1.08-1.45), multivessel disease (HR 1.22, 95%CI 1.06-1.39), prior myocardial infarction (MI) (HR 1.24, 95%CI 1.06-1.45), and out-of-hospital cardiac arrest (OHCA) (HR 1.71, 95%CI 1.50-1.94). In conclusion, in this Dutch nationwide registry-based study of ACS patients treated by PCI, the incidence of CS was 4.1% over the 4-year study period. Predictors for mortality in CS were higher age, renal insufficiency, presence of DM, multivessel disease, prior MI, and OHCA.
AB - It is important to gain more insight into the cardiogenic shock (CS) population, as currently, little is known on how to improve outcomes. Therefore, we assessed clinical outcome in acute coronary syndrome (ACS) patients treated by percutaneous coronary intervention (PCI) with and without CS at admission. Furthermore, the incidence of CS and predictors for mortality in CS patients were evaluated. The Netherlands Heart Registration (NHR) is a nationwide registry on all cardiac interventions. We used NHR data of ACS patients treated with PCI between 2015 and 2019. Among 75,407 ACS patients treated with PCI, 3028 patients (4.1%) were identified with CS, respectively 4.3%, 3.9%, 3.5%, and 4.3% per year. Factors associated with mortality in CS were age (HR 1.02, 95%CI 1.02-1.03), eGFR (HR 0.98, 95%CI 0.98-0.99), diabetes mellitus (DM) (HR 1.25, 95%CI 1.08-1.45), multivessel disease (HR 1.22, 95%CI 1.06-1.39), prior myocardial infarction (MI) (HR 1.24, 95%CI 1.06-1.45), and out-of-hospital cardiac arrest (OHCA) (HR 1.71, 95%CI 1.50-1.94). In conclusion, in this Dutch nationwide registry-based study of ACS patients treated by PCI, the incidence of CS was 4.1% over the 4-year study period. Predictors for mortality in CS were higher age, renal insufficiency, presence of DM, multivessel disease, prior MI, and OHCA.
U2 - 10.3390/jcm10102047
DO - 10.3390/jcm10102047
M3 - Article
C2 - 34064638
VL - 10
JO - Journal of clinical medicine
JF - Journal of clinical medicine
SN - 2077-0383
IS - 10
ER -
ID: 20768410