Research output: Contribution to journal › Article › Academic › peer-review
Morphologic Mapping of the Sublingual Microcirculation in Healthy Volunteers. / Güven, G. ksel; Uz, Z. hre; Hilty, Matthias P. et al.
In: Journal of vascular research, Vol. 59, No. 4, 01.07.2022, p. 199-208.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Morphologic Mapping of the Sublingual Microcirculation in Healthy Volunteers
AU - Güven, G. ksel
AU - Uz, Z. hre
AU - Hilty, Matthias P.
AU - Bilecenoǧlu, Burak
AU - Akin, Șakir
AU - Ince, Yasin
AU - Ince, Can
N1 - Publisher Copyright: © 2022 The Author(s).
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Purpose: Monitoring the sublingual and oral microcirculation (SM-OM) using hand-held vital microscopes (HVMs) has provided valuable insight into the (patho)physiology of diseases. However, the microvascular anatomy in a healthy population has not been adequately described yet. Methods: Incident dark field-based HVM imaging was used to visualize the SM-OM. First, the SM was divided into four different fields; Field-a (between incisors-lingua), Field-b (between the canine-first premolar-lingua), Field-c (between the first-second premolar-lingua), Field-d (between the second molar-wisdom teeth-lingua). Second, we investigated the buccal area, lower and upper lip. Total/functional vessel density (TVD/FCD), focus depth (FD), small vessel mean diameters (SVMDs), and capillary tortuosity score (CTS) were compared between the areas. Results: Fifteen volunteers with a mean age of 29 ± 6 years were enrolled. No statistical difference was found between the sublingual fields in terms of TVD (p = 0.30), FCD (p = 0.38), and FD (p = 0.09). SVMD was similar in Field-a, Field-b, and Field-c (p = 0.20-0.30), and larger in Field-d (p < 0.01, p = 0.015). The CTS of the buccal area was higher than in the lips. Conclusion: The sublingual area has a homogenous distribution in TVD, FCD, FD, and SVMD. This study can be a description of the normal microvascular anatomy for future researches regarding microcirculatory assessment.
AB - Purpose: Monitoring the sublingual and oral microcirculation (SM-OM) using hand-held vital microscopes (HVMs) has provided valuable insight into the (patho)physiology of diseases. However, the microvascular anatomy in a healthy population has not been adequately described yet. Methods: Incident dark field-based HVM imaging was used to visualize the SM-OM. First, the SM was divided into four different fields; Field-a (between incisors-lingua), Field-b (between the canine-first premolar-lingua), Field-c (between the first-second premolar-lingua), Field-d (between the second molar-wisdom teeth-lingua). Second, we investigated the buccal area, lower and upper lip. Total/functional vessel density (TVD/FCD), focus depth (FD), small vessel mean diameters (SVMDs), and capillary tortuosity score (CTS) were compared between the areas. Results: Fifteen volunteers with a mean age of 29 ± 6 years were enrolled. No statistical difference was found between the sublingual fields in terms of TVD (p = 0.30), FCD (p = 0.38), and FD (p = 0.09). SVMD was similar in Field-a, Field-b, and Field-c (p = 0.20-0.30), and larger in Field-d (p < 0.01, p = 0.015). The CTS of the buccal area was higher than in the lips. Conclusion: The sublingual area has a homogenous distribution in TVD, FCD, FD, and SVMD. This study can be a description of the normal microvascular anatomy for future researches regarding microcirculatory assessment.
KW - Capillary
KW - IDF imaging
KW - Mapping
KW - Microcirculation
KW - Sublingual
UR - http://www.scopus.com/inward/record.url?scp=85127866026&partnerID=8YFLogxK
U2 - 10.1159/000522394
DO - 10.1159/000522394
M3 - Article
C2 - 35313312
VL - 59
SP - 199
EP - 208
JO - Journal of vascular research
JF - Journal of vascular research
SN - 1018-1172
IS - 4
ER -
ID: 23057837