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Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. / Hermanns, Henning; Hollmann, Markus W.; Stevens, Markus F.; Lirk, Philipp; Brandenburger, Timo; Piegeler, Tobias; Werdehausen, Robert.

In: British journal of anaesthesia, Vol. 123, No. 3, 09.2019, p. 335–349.

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Hermanns, Henning ; Hollmann, Markus W. ; Stevens, Markus F. ; Lirk, Philipp ; Brandenburger, Timo ; Piegeler, Tobias ; Werdehausen, Robert. / Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. In: British journal of anaesthesia. 2019 ; Vol. 123, No. 3. pp. 335–349.

BibTeX

@article{d0afe4ce28984a6dae4713973f9042d6,
title = "Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review",
abstract = "Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain. These effects cannot be explained by its voltage-gated sodium channel blocking properties alone, but the responsible mechanisms are still elusive. This narrative review focuses on available experimental evidence of the molecular mechanisms by which systemic lidocaine exerts its clinically documented analgesic effects. These include effects on the peripheral nervous system and CNS, where lidocaine acts via silencing ectopic discharges, suppression of inflammatory processes, and modulation of inhibitory and excitatory neurotransmission. We highlight promising objectives for future research to further unravel these antinociceptive mechanisms, which subsequently may facilitate the development of new analgesic strategies and therapies for acute and chronic pain.",
author = "Henning Hermanns and Hollmann, {Markus W.} and Stevens, {Markus F.} and Philipp Lirk and Timo Brandenburger and Tobias Piegeler and Robert Werdehausen",
note = "Copyright {\circledC} 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.",
year = "2019",
month = "9",
doi = "10.1016/j.bja.2019.06.014",
language = "English",
volume = "123",
pages = "335–349",
journal = "British journal of anaesthesia",
issn = "0007-0912",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review

AU - Hermanns, Henning

AU - Hollmann, Markus W.

AU - Stevens, Markus F.

AU - Lirk, Philipp

AU - Brandenburger, Timo

AU - Piegeler, Tobias

AU - Werdehausen, Robert

N1 - Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

PY - 2019/9

Y1 - 2019/9

N2 - Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain. These effects cannot be explained by its voltage-gated sodium channel blocking properties alone, but the responsible mechanisms are still elusive. This narrative review focuses on available experimental evidence of the molecular mechanisms by which systemic lidocaine exerts its clinically documented analgesic effects. These include effects on the peripheral nervous system and CNS, where lidocaine acts via silencing ectopic discharges, suppression of inflammatory processes, and modulation of inhibitory and excitatory neurotransmission. We highlight promising objectives for future research to further unravel these antinociceptive mechanisms, which subsequently may facilitate the development of new analgesic strategies and therapies for acute and chronic pain.

AB - Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute and chronic pain states, especially in acute postoperative and chronic neuropathic pain. These effects cannot be explained by its voltage-gated sodium channel blocking properties alone, but the responsible mechanisms are still elusive. This narrative review focuses on available experimental evidence of the molecular mechanisms by which systemic lidocaine exerts its clinically documented analgesic effects. These include effects on the peripheral nervous system and CNS, where lidocaine acts via silencing ectopic discharges, suppression of inflammatory processes, and modulation of inhibitory and excitatory neurotransmission. We highlight promising objectives for future research to further unravel these antinociceptive mechanisms, which subsequently may facilitate the development of new analgesic strategies and therapies for acute and chronic pain.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068546551&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/31303268

U2 - 10.1016/j.bja.2019.06.014

DO - 10.1016/j.bja.2019.06.014

M3 - Review article

C2 - 31303268

VL - 123

SP - 335

EP - 349

JO - British journal of anaesthesia

JF - British journal of anaesthesia

SN - 0007-0912

IS - 3

ER -

ID: 6729758