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Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine. / Meessen, Emma C. E.; Sips, Fianne L. P.; Eggink, Hannah M. et al.

In: Physiological reports, Vol. 8, No. 5, e14358, 01.03.2020.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Meessen, ECE, Sips, FLP, Eggink, HM, Koehorst, M, Romijn, JA, Groen, AK, van Riel, NAW & Soeters, MR 2020, 'Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine', Physiological reports, vol. 8, no. 5, e14358. https://doi.org/10.14814/phy2.14358

APA

Meessen, E. C. E., Sips, F. L. P., Eggink, H. M., Koehorst, M., Romijn, J. A., Groen, A. K., van Riel, N. A. W., & Soeters, M. R. (2020). Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine. Physiological reports, 8(5), [e14358]. https://doi.org/10.14814/phy2.14358

Vancouver

Meessen ECE, Sips FLP, Eggink HM, Koehorst M, Romijn JA, Groen AK et al. Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine. Physiological reports. 2020 Mar 1;8(5):e14358. doi: 10.14814/phy2.14358

Author

Meessen, Emma C. E. ; Sips, Fianne L. P. ; Eggink, Hannah M. et al. / Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine. In: Physiological reports. 2020 ; Vol. 8, No. 5.

BibTeX

@article{0559fa2a28e344af89243ebba588ff8f,
title = "Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine",
abstract = "Background: Bile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein-coupled receptor 5 (TGR5). The postprandial increase in plasma bile acid concentrations is therefore a potential metabolic signal. However, this postprandial response has a high interindividual variability. Such variability may affect bile acid receptor activation. Methods: In this study, we analyzed the inter- and intraindividual variability of fasting and postprandial bile acid concentrations during three identical meals on separate days in eight healthy lean male subjects using a statistical and mathematical approach. Main findings: The postprandial bile acid responses exhibited large interindividual and intraindividual variability. The individual mathematical models, which represent the enterohepatic circulation of bile acids in each subject, suggest that interindividual variability results from quantitative and qualitative differences of distal active uptake, colon transit, and microbial bile acid transformation. Conversely, intraindividual variations in gallbladder kinetics can explain intraindividual differences in the postprandial responses. Conclusions: We conclude that there is considerable inter- and intraindividual variation in postprandial plasma bile acid levels. The presented personalized approach is a promising tool to identify unique characteristics of underlying physiological processes and can be applied to investigate bile acid metabolism in pathophysiological conditions.",
keywords = "interindividual variability, intraindividual variability, mathematical modeling, mixed meal test, postprandial bile acid metabolism",
author = "Meessen, {Emma C. E.} and Sips, {Fianne L. P.} and Eggink, {Hannah M.} and Martijn Koehorst and Romijn, {Johannes A.} and Groen, {Albert K.} and {van Riel}, {Natal A. W.} and Soeters, {Maarten R.}",
year = "2020",
month = mar,
day = "1",
doi = "10.14814/phy2.14358",
language = "English",
volume = "8",
journal = "Physiological reports",
issn = "2051-817X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine

AU - Meessen, Emma C. E.

AU - Sips, Fianne L. P.

AU - Eggink, Hannah M.

AU - Koehorst, Martijn

AU - Romijn, Johannes A.

AU - Groen, Albert K.

AU - van Riel, Natal A. W.

AU - Soeters, Maarten R.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Background: Bile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein-coupled receptor 5 (TGR5). The postprandial increase in plasma bile acid concentrations is therefore a potential metabolic signal. However, this postprandial response has a high interindividual variability. Such variability may affect bile acid receptor activation. Methods: In this study, we analyzed the inter- and intraindividual variability of fasting and postprandial bile acid concentrations during three identical meals on separate days in eight healthy lean male subjects using a statistical and mathematical approach. Main findings: The postprandial bile acid responses exhibited large interindividual and intraindividual variability. The individual mathematical models, which represent the enterohepatic circulation of bile acids in each subject, suggest that interindividual variability results from quantitative and qualitative differences of distal active uptake, colon transit, and microbial bile acid transformation. Conversely, intraindividual variations in gallbladder kinetics can explain intraindividual differences in the postprandial responses. Conclusions: We conclude that there is considerable inter- and intraindividual variation in postprandial plasma bile acid levels. The presented personalized approach is a promising tool to identify unique characteristics of underlying physiological processes and can be applied to investigate bile acid metabolism in pathophysiological conditions.

AB - Background: Bile acids are multifaceted metabolic compounds that signal to cholesterol, glucose, and lipid homeostasis via receptors like the Farnesoid X Receptor (FXR) and transmembrane Takeda G protein-coupled receptor 5 (TGR5). The postprandial increase in plasma bile acid concentrations is therefore a potential metabolic signal. However, this postprandial response has a high interindividual variability. Such variability may affect bile acid receptor activation. Methods: In this study, we analyzed the inter- and intraindividual variability of fasting and postprandial bile acid concentrations during three identical meals on separate days in eight healthy lean male subjects using a statistical and mathematical approach. Main findings: The postprandial bile acid responses exhibited large interindividual and intraindividual variability. The individual mathematical models, which represent the enterohepatic circulation of bile acids in each subject, suggest that interindividual variability results from quantitative and qualitative differences of distal active uptake, colon transit, and microbial bile acid transformation. Conversely, intraindividual variations in gallbladder kinetics can explain intraindividual differences in the postprandial responses. Conclusions: We conclude that there is considerable inter- and intraindividual variation in postprandial plasma bile acid levels. The presented personalized approach is a promising tool to identify unique characteristics of underlying physiological processes and can be applied to investigate bile acid metabolism in pathophysiological conditions.

KW - interindividual variability

KW - intraindividual variability

KW - mathematical modeling

KW - mixed meal test

KW - postprandial bile acid metabolism

UR - http://www.scopus.com/inward/record.url?scp=85081397391&partnerID=8YFLogxK

U2 - 10.14814/phy2.14358

DO - 10.14814/phy2.14358

M3 - Article

C2 - 32170845

VL - 8

JO - Physiological reports

JF - Physiological reports

SN - 2051-817X

IS - 5

M1 - e14358

ER -

ID: 11195357