Standard

Mitral Valve Disease in Ankylosing Spondylitis: an autoimmune disease manifestation? A case report. / el Mathari, Sulayman; van der Wal, Allard C.; Raterman, Hennie; Kluin, Jolanda.

In: European Heart Journal - Case Reports, 03.08.2022.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

APA

Vancouver

Author

BibTeX

@article{6cca1d912c0140fcad553f230b034407,
title = "Mitral Valve Disease in Ankylosing Spondylitis: an autoimmune disease manifestation? A case report",
abstract = "BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory disease of primarily the joints of the spine. In literature, AS is known to have cardiac manifestations. Most frequently, this is aortic regurgitation. However, in rare cases also mitral valve disease is observed in AS patients. The extent and mechanism of this involvement is still unclear. We aim to describe a histologically validated case report to add understanding on this topic.Case summaryWe show the case of a 51-year-old male who suffered since his youth from back pain and uveitis, which was later diagnosed as AS. After a first presentation with combined heart valve disease, the patient recovered on cardiac medical therapy and biologic treatment for AS. Four years later, cardiac complaints worsened mainly due to severe mitral valve stenosis. Surgical treatment was performed with histopathologic analysis of the excised mitral valve validating involvement of AS.DiscussionHistopathologic analysis showed chronic fibro inflammatory thickening of the mitral valve leaflets and subvalvular apparatus. These pathological features could fit with the inflammatory nature of AS. Since this is a rare case, the recognition of fibro inflammatory thickening leading to commissural fusion and stenosis may contribute to better understanding of heart valve disease in AS to create a base for better cardiac management in this specific patient group.",
author = "{el Mathari}, Sulayman and {van der Wal}, {Allard C.} and Hennie Raterman and Jolanda Kluin",
year = "2022",
month = aug,
day = "3",
language = "English",
journal = "European Heart Journal - Case Reports",
issn = "2514-2119",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Mitral Valve Disease in Ankylosing Spondylitis: an autoimmune disease manifestation? A case report

AU - el Mathari, Sulayman

AU - van der Wal, Allard C.

AU - Raterman, Hennie

AU - Kluin, Jolanda

PY - 2022/8/3

Y1 - 2022/8/3

N2 - BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory disease of primarily the joints of the spine. In literature, AS is known to have cardiac manifestations. Most frequently, this is aortic regurgitation. However, in rare cases also mitral valve disease is observed in AS patients. The extent and mechanism of this involvement is still unclear. We aim to describe a histologically validated case report to add understanding on this topic.Case summaryWe show the case of a 51-year-old male who suffered since his youth from back pain and uveitis, which was later diagnosed as AS. After a first presentation with combined heart valve disease, the patient recovered on cardiac medical therapy and biologic treatment for AS. Four years later, cardiac complaints worsened mainly due to severe mitral valve stenosis. Surgical treatment was performed with histopathologic analysis of the excised mitral valve validating involvement of AS.DiscussionHistopathologic analysis showed chronic fibro inflammatory thickening of the mitral valve leaflets and subvalvular apparatus. These pathological features could fit with the inflammatory nature of AS. Since this is a rare case, the recognition of fibro inflammatory thickening leading to commissural fusion and stenosis may contribute to better understanding of heart valve disease in AS to create a base for better cardiac management in this specific patient group.

AB - BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory disease of primarily the joints of the spine. In literature, AS is known to have cardiac manifestations. Most frequently, this is aortic regurgitation. However, in rare cases also mitral valve disease is observed in AS patients. The extent and mechanism of this involvement is still unclear. We aim to describe a histologically validated case report to add understanding on this topic.Case summaryWe show the case of a 51-year-old male who suffered since his youth from back pain and uveitis, which was later diagnosed as AS. After a first presentation with combined heart valve disease, the patient recovered on cardiac medical therapy and biologic treatment for AS. Four years later, cardiac complaints worsened mainly due to severe mitral valve stenosis. Surgical treatment was performed with histopathologic analysis of the excised mitral valve validating involvement of AS.DiscussionHistopathologic analysis showed chronic fibro inflammatory thickening of the mitral valve leaflets and subvalvular apparatus. These pathological features could fit with the inflammatory nature of AS. Since this is a rare case, the recognition of fibro inflammatory thickening leading to commissural fusion and stenosis may contribute to better understanding of heart valve disease in AS to create a base for better cardiac management in this specific patient group.

M3 - Article

JO - European Heart Journal - Case Reports

JF - European Heart Journal - Case Reports

SN - 2514-2119

ER -

ID: 25262705