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Maternal, perinatal and childhood outcomes of the PPROMEXIL-III cohort: Pregnancies complicated by previable prelabor rupture of membranes. / Simons, Noor E.; de Ruigh, Annemijn A.; van der Windt, Larissa I.; Kazemier, Brenda M.; van Wassenaer-Leemhuis, Aleid G.; van Teeffelen, Augustinus S.; van Leeuwen, Elisabeth; Mol, Ben Willem; van 't Hooft, Janneke; Pajkrt, Eva.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 265, 01.10.2021, p. 44-53.

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@article{da4b36cd96ba4a4389c3fe5265611c5e,
title = "Maternal, perinatal and childhood outcomes of the PPROMEXIL-III cohort: Pregnancies complicated by previable prelabor rupture of membranes",
abstract = "Objective: Perinatal mortality after previable prelabor rupture of membranes (previable PROM) might be underestimated as most studies exclude patients with poor prognosis, or solely include patients in tertiary-care centers. We aimed to report perinatal, neonatal and long-term outcomes in a consecutive series of women with pregnancies complicated by previable PROM. Study design: We conducted a prospective cohort study including women with singleton pregnancies and previable PROM ≤ 23+6 weeks gestational age (GA) from one tertiary hospital and eight affiliated secondary hospitals in the region of Amsterdam, the Netherlands (June 2012 until January 2016, PPROMEXIL-III cohort). Exclusion criteria were signs of active labor before onset of PROM or fetal structural anomalies visible at ultrasound. We assessed perinatal mortality. Furthermore, outcomes were maternal, perinatal, neonatal and long-term child characteristics. Results: We included 98 pregnancies with previable PROM. Twelve women (12.2%) opted for termination of pregnancy, resulting in 86 pregnancies included in further analyses. Median GA at PROM was 20+2 weeks (interquartile range (IQR) 17+6-22+0). Median GA at delivery was 22+6 weeks (IQR 20+1-26+4). Delivery within 1 week occurred in 38.4% of women and 60.4% delivered before 24 weeks GA (viability). Perinatal mortality occurred in 73.3% of pregnancies. 23/33 (69.7%) live-born neonates survived to discharge, representing 26.7% of total. None of the children died after discharge. Developmental data at two and/or five years of age was available for 13/23 children (i.e. all children born before 32 weeks of gestation), with 69.2% of children reporting a normal neurodevelopment. However, more than half of children reported respiratory problems. Conclusion: In women with previable PROM perinatal mortality was 73.3%, with a normal neurodevelopment in 69.2% of surviving children with follow-up data. Due to broad inclusion criteria, this cohort represents a population more generalizable to daily practice as compared to previous studies.",
keywords = "Long-term outcome, Neurodevelopment, PPROM, Perinatal mortality, Preterm prelabor rupture of membranes, Previable PROM, Survival",
author = "Simons, {Noor E.} and {de Ruigh}, {Annemijn A.} and {van der Windt}, {Larissa I.} and Kazemier, {Brenda M.} and {van Wassenaer-Leemhuis}, {Aleid G.} and {van Teeffelen}, {Augustinus S.} and {van Leeuwen}, Elisabeth and Mol, {Ben Willem} and {van 't Hooft}, Janneke and Eva Pajkrt",
note = "Funding Information: Not applicable. The Medical Ethics Committee of the Amsterdam UMC deemed that the Medical Research Involving Human Subjects Act (WMO) did not apply to this study (W20_040) and official approval was therefore not required. No funding source. NS, AdR and LvdW participated in protocol development, data collection, data analysis, interpretation and writing. BK, AvWL, AvT, EvL, BM, JvtH and EP participated in protocol development, data analysis, data interpretation and writing. All collaborators saw and approved the final version. All collaborators were sent the paper as prepared for submission and given the opportunity to comment on the draft manuscript. Funding Information: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Ben Willem Mol is supported by a NHMRC Practitioner Fellowship (GNT1082548). Dr. Ben Willem Mol reports consultancy for ObsEva, Merck Merck KGaA and Guerbet. The other authors do not report any potential conflicts of interest. Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = oct,
day = "1",
doi = "10.1016/j.ejogrb.2021.08.007",
language = "English",
volume = "265",
pages = "44--53",
journal = "European journal of obstetrics, gynecology, and reproductive biology",
issn = "0301-2115",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Maternal, perinatal and childhood outcomes of the PPROMEXIL-III cohort: Pregnancies complicated by previable prelabor rupture of membranes

AU - Simons, Noor E.

AU - de Ruigh, Annemijn A.

AU - van der Windt, Larissa I.

AU - Kazemier, Brenda M.

AU - van Wassenaer-Leemhuis, Aleid G.

AU - van Teeffelen, Augustinus S.

AU - van Leeuwen, Elisabeth

AU - Mol, Ben Willem

AU - van 't Hooft, Janneke

AU - Pajkrt, Eva

N1 - Funding Information: Not applicable. The Medical Ethics Committee of the Amsterdam UMC deemed that the Medical Research Involving Human Subjects Act (WMO) did not apply to this study (W20_040) and official approval was therefore not required. No funding source. NS, AdR and LvdW participated in protocol development, data collection, data analysis, interpretation and writing. BK, AvWL, AvT, EvL, BM, JvtH and EP participated in protocol development, data analysis, data interpretation and writing. All collaborators saw and approved the final version. All collaborators were sent the paper as prepared for submission and given the opportunity to comment on the draft manuscript. Funding Information: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Ben Willem Mol is supported by a NHMRC Practitioner Fellowship (GNT1082548). Dr. Ben Willem Mol reports consultancy for ObsEva, Merck Merck KGaA and Guerbet. The other authors do not report any potential conflicts of interest. Publisher Copyright: © 2021 The Authors

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Objective: Perinatal mortality after previable prelabor rupture of membranes (previable PROM) might be underestimated as most studies exclude patients with poor prognosis, or solely include patients in tertiary-care centers. We aimed to report perinatal, neonatal and long-term outcomes in a consecutive series of women with pregnancies complicated by previable PROM. Study design: We conducted a prospective cohort study including women with singleton pregnancies and previable PROM ≤ 23+6 weeks gestational age (GA) from one tertiary hospital and eight affiliated secondary hospitals in the region of Amsterdam, the Netherlands (June 2012 until January 2016, PPROMEXIL-III cohort). Exclusion criteria were signs of active labor before onset of PROM or fetal structural anomalies visible at ultrasound. We assessed perinatal mortality. Furthermore, outcomes were maternal, perinatal, neonatal and long-term child characteristics. Results: We included 98 pregnancies with previable PROM. Twelve women (12.2%) opted for termination of pregnancy, resulting in 86 pregnancies included in further analyses. Median GA at PROM was 20+2 weeks (interquartile range (IQR) 17+6-22+0). Median GA at delivery was 22+6 weeks (IQR 20+1-26+4). Delivery within 1 week occurred in 38.4% of women and 60.4% delivered before 24 weeks GA (viability). Perinatal mortality occurred in 73.3% of pregnancies. 23/33 (69.7%) live-born neonates survived to discharge, representing 26.7% of total. None of the children died after discharge. Developmental data at two and/or five years of age was available for 13/23 children (i.e. all children born before 32 weeks of gestation), with 69.2% of children reporting a normal neurodevelopment. However, more than half of children reported respiratory problems. Conclusion: In women with previable PROM perinatal mortality was 73.3%, with a normal neurodevelopment in 69.2% of surviving children with follow-up data. Due to broad inclusion criteria, this cohort represents a population more generalizable to daily practice as compared to previous studies.

AB - Objective: Perinatal mortality after previable prelabor rupture of membranes (previable PROM) might be underestimated as most studies exclude patients with poor prognosis, or solely include patients in tertiary-care centers. We aimed to report perinatal, neonatal and long-term outcomes in a consecutive series of women with pregnancies complicated by previable PROM. Study design: We conducted a prospective cohort study including women with singleton pregnancies and previable PROM ≤ 23+6 weeks gestational age (GA) from one tertiary hospital and eight affiliated secondary hospitals in the region of Amsterdam, the Netherlands (June 2012 until January 2016, PPROMEXIL-III cohort). Exclusion criteria were signs of active labor before onset of PROM or fetal structural anomalies visible at ultrasound. We assessed perinatal mortality. Furthermore, outcomes were maternal, perinatal, neonatal and long-term child characteristics. Results: We included 98 pregnancies with previable PROM. Twelve women (12.2%) opted for termination of pregnancy, resulting in 86 pregnancies included in further analyses. Median GA at PROM was 20+2 weeks (interquartile range (IQR) 17+6-22+0). Median GA at delivery was 22+6 weeks (IQR 20+1-26+4). Delivery within 1 week occurred in 38.4% of women and 60.4% delivered before 24 weeks GA (viability). Perinatal mortality occurred in 73.3% of pregnancies. 23/33 (69.7%) live-born neonates survived to discharge, representing 26.7% of total. None of the children died after discharge. Developmental data at two and/or five years of age was available for 13/23 children (i.e. all children born before 32 weeks of gestation), with 69.2% of children reporting a normal neurodevelopment. However, more than half of children reported respiratory problems. Conclusion: In women with previable PROM perinatal mortality was 73.3%, with a normal neurodevelopment in 69.2% of surviving children with follow-up data. Due to broad inclusion criteria, this cohort represents a population more generalizable to daily practice as compared to previous studies.

KW - Long-term outcome

KW - Neurodevelopment

KW - PPROM

KW - Perinatal mortality

KW - Preterm prelabor rupture of membranes

KW - Previable PROM

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85113633431&partnerID=8YFLogxK

U2 - 10.1016/j.ejogrb.2021.08.007

DO - 10.1016/j.ejogrb.2021.08.007

M3 - Article

C2 - 34428686

VL - 265

SP - 44

EP - 53

JO - European journal of obstetrics, gynecology, and reproductive biology

JF - European journal of obstetrics, gynecology, and reproductive biology

SN - 0301-2115

ER -

ID: 19508229