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Low level of HIV-1 evolution after transmission from mother to child. / Gijsbers, Esther F.; van Nuenen, Ad C.; de la Peňa, Alba Torrents et al.

In: Scientific reports, Vol. 4, 2014, p. 5079.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Gijsbers, EF, van Nuenen, AC, de la Peňa, AT, Bowles, EJ, Stewart-Jones, GB, Schuitemaker, H & Kootstra, NA 2014, 'Low level of HIV-1 evolution after transmission from mother to child', Scientific reports, vol. 4, pp. 5079. https://doi.org/10.1038/srep05079

APA

Gijsbers, E. F., van Nuenen, A. C., de la Peňa, A. T., Bowles, E. J., Stewart-Jones, G. B., Schuitemaker, H., & Kootstra, N. A. (2014). Low level of HIV-1 evolution after transmission from mother to child. Scientific reports, 4, 5079. https://doi.org/10.1038/srep05079

Vancouver

Gijsbers EF, van Nuenen AC, de la Peňa AT, Bowles EJ, Stewart-Jones GB, Schuitemaker H et al. Low level of HIV-1 evolution after transmission from mother to child. Scientific reports. 2014;4:5079. doi: 10.1038/srep05079

Author

Gijsbers, Esther F. ; van Nuenen, Ad C. ; de la Peňa, Alba Torrents et al. / Low level of HIV-1 evolution after transmission from mother to child. In: Scientific reports. 2014 ; Vol. 4. pp. 5079.

BibTeX

@article{c56b9770b73f4cdc8670a238ba1632dc,
title = "Low level of HIV-1 evolution after transmission from mother to child",
abstract = "Mother-to-child HIV-1 transmission pairs represent a good opportunity to study the dynamics of CTL escape and reversion after transmission in the light of shared and non-shared HLA-alleles. Mothers share half of their HLA alleles with their children, while the other half is inherited from the father and is generally discordant between mother and child. This implies that HIV-1 transmitted from mother to child enters a host environment to which it has already partially adapted. Here, we studied viral evolution and the dynamics of CTL escape mutations and reversion of these mutations after transmission in the context of shared and non-shared HLA alleles in viral variants obtained from five mother-to-child transmission pairs. Only limited HIV-1 evolution was observed in the children after mother-to-child transmission. Viral evolution was mainly driven by forward mutations located inside CTL epitopes restricted by HLA alleles inherited from the father, which may be indicative of CTL pressure",
author = "Gijsbers, {Esther F.} and {van Nuenen}, {Ad C.} and {de la Pe{\v n}a}, {Alba Torrents} and Bowles, {Emma J.} and Stewart-Jones, {Guillaume B.} and Hanneke Schuitemaker and Kootstra, {Neeltje A.}",
year = "2014",
doi = "10.1038/srep05079",
language = "English",
volume = "4",
pages = "5079",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Low level of HIV-1 evolution after transmission from mother to child

AU - Gijsbers, Esther F.

AU - van Nuenen, Ad C.

AU - de la Peňa, Alba Torrents

AU - Bowles, Emma J.

AU - Stewart-Jones, Guillaume B.

AU - Schuitemaker, Hanneke

AU - Kootstra, Neeltje A.

PY - 2014

Y1 - 2014

N2 - Mother-to-child HIV-1 transmission pairs represent a good opportunity to study the dynamics of CTL escape and reversion after transmission in the light of shared and non-shared HLA-alleles. Mothers share half of their HLA alleles with their children, while the other half is inherited from the father and is generally discordant between mother and child. This implies that HIV-1 transmitted from mother to child enters a host environment to which it has already partially adapted. Here, we studied viral evolution and the dynamics of CTL escape mutations and reversion of these mutations after transmission in the context of shared and non-shared HLA alleles in viral variants obtained from five mother-to-child transmission pairs. Only limited HIV-1 evolution was observed in the children after mother-to-child transmission. Viral evolution was mainly driven by forward mutations located inside CTL epitopes restricted by HLA alleles inherited from the father, which may be indicative of CTL pressure

AB - Mother-to-child HIV-1 transmission pairs represent a good opportunity to study the dynamics of CTL escape and reversion after transmission in the light of shared and non-shared HLA-alleles. Mothers share half of their HLA alleles with their children, while the other half is inherited from the father and is generally discordant between mother and child. This implies that HIV-1 transmitted from mother to child enters a host environment to which it has already partially adapted. Here, we studied viral evolution and the dynamics of CTL escape mutations and reversion of these mutations after transmission in the context of shared and non-shared HLA alleles in viral variants obtained from five mother-to-child transmission pairs. Only limited HIV-1 evolution was observed in the children after mother-to-child transmission. Viral evolution was mainly driven by forward mutations located inside CTL epitopes restricted by HLA alleles inherited from the father, which may be indicative of CTL pressure

U2 - 10.1038/srep05079

DO - 10.1038/srep05079

M3 - Article

C2 - 24866155

VL - 4

SP - 5079

JO - Scientific reports

JF - Scientific reports

SN - 2045-2322

ER -

ID: 2415156