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Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. / Houthuizen, Patrick; van Garsse, Leen A. F. M.; Poels, Thomas T.; de Jaegere, Peter; van der Boon, Robert M. A.; Swinkels, Ben M.; ten Berg, Jurriën M.; van der Kley, Frank; Schalij, Martin J.; Baan, Jan; Cocchieri, Ricardo; Brueren, Guus R. G.; van Straten, Albert H. M.; den Heijer, Peter; Bentala, Mohamed; van Ommen, Vincent; Kluin, Jolanda; Stella, Pieter R.; Prins, Martin H.; Maessen, Jos G.; Prinzen, Frits W.

In: Circulation, Vol. 126, No. 6, 2012, p. 720-728.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Houthuizen, P, van Garsse, LAFM, Poels, TT, de Jaegere, P, van der Boon, RMA, Swinkels, BM, ten Berg, JM, van der Kley, F, Schalij, MJ, Baan, J, Cocchieri, R, Brueren, GRG, van Straten, AHM, den Heijer, P, Bentala, M, van Ommen, V, Kluin, J, Stella, PR, Prins, MH, Maessen, JG & Prinzen, FW 2012, 'Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death', Circulation, vol. 126, no. 6, pp. 720-728. https://doi.org/10.1161/CIRCULATIONAHA.112.101055

APA

Houthuizen, P., van Garsse, L. A. F. M., Poels, T. T., de Jaegere, P., van der Boon, R. M. A., Swinkels, B. M., ten Berg, J. M., van der Kley, F., Schalij, M. J., Baan, J., Cocchieri, R., Brueren, G. R. G., van Straten, A. H. M., den Heijer, P., Bentala, M., van Ommen, V., Kluin, J., Stella, P. R., Prins, M. H., ... Prinzen, F. W. (2012). Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. Circulation, 126(6), 720-728. https://doi.org/10.1161/CIRCULATIONAHA.112.101055

Vancouver

Houthuizen P, van Garsse LAFM, Poels TT, de Jaegere P, van der Boon RMA, Swinkels BM et al. Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. Circulation. 2012;126(6):720-728. https://doi.org/10.1161/CIRCULATIONAHA.112.101055

Author

Houthuizen, Patrick ; van Garsse, Leen A. F. M. ; Poels, Thomas T. ; de Jaegere, Peter ; van der Boon, Robert M. A. ; Swinkels, Ben M. ; ten Berg, Jurriën M. ; van der Kley, Frank ; Schalij, Martin J. ; Baan, Jan ; Cocchieri, Ricardo ; Brueren, Guus R. G. ; van Straten, Albert H. M. ; den Heijer, Peter ; Bentala, Mohamed ; van Ommen, Vincent ; Kluin, Jolanda ; Stella, Pieter R. ; Prins, Martin H. ; Maessen, Jos G. ; Prinzen, Frits W. / Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death. In: Circulation. 2012 ; Vol. 126, No. 6. pp. 720-728.

BibTeX

@article{87433f042e7e480399f11cec3c4757a8,
title = "Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death",
abstract = "Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interquartile range, 253-725) days in patients without LBBB (P=0.90). All cause mortality was 37.8% (n=88) in patients with LBBB and 24.0% (n=107) patients without LBBB (P=0.002). By multivariate regression analysis, indepedent predictors of all-cause mortality were TAVI-induced LBBB (hazard ratio [HR], 1.54; condifence interval [CI], 1.12-2.10), chronic obstructive lung disease (HR, 1.56; CI, 1.15-2.10), female sex (HR, 1.39; CI, 1.04-1.85), left ventricular ejection fraction <= 50% (HR, 1.38; CI, 1.02-1.86), and baseline creatinine (HR, 1.32; CI, 1.19-1.43). LBBB was more frequent after implantation of the Medtronic Core Valve System than after Edwards SAPIEN implantation (51.1% and 12.0%, respectively; P <0.001), but device type did not influence the mortality risk of TAVI-induced LBBB. Conclusions-All-cause mortality after TAVI is higher in patients who develop LBBB than in patients who do not. TAVI-induced LBBB is an independent predictor of mortality. (Circulation. 2012;126:720-728.)",
author = "Patrick Houthuizen and {van Garsse}, {Leen A. F. M.} and Poels, {Thomas T.} and {de Jaegere}, Peter and {van der Boon}, {Robert M. A.} and Swinkels, {Ben M.} and {ten Berg}, {Jurri{\"e}n M.} and {van der Kley}, Frank and Schalij, {Martin J.} and Jan Baan and Ricardo Cocchieri and Brueren, {Guus R. G.} and {van Straten}, {Albert H. M.} and {den Heijer}, Peter and Mohamed Bentala and {van Ommen}, Vincent and Jolanda Kluin and Stella, {Pieter R.} and Prins, {Martin H.} and Maessen, {Jos G.} and Prinzen, {Frits W.}",
year = "2012",
doi = "10.1161/CIRCULATIONAHA.112.101055",
language = "English",
volume = "126",
pages = "720--728",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Left Bundle-Branch Block Induced by Transcatheter Aortic Valve Implantation Increases Risk of Death

AU - Houthuizen, Patrick

AU - van Garsse, Leen A. F. M.

AU - Poels, Thomas T.

AU - de Jaegere, Peter

AU - van der Boon, Robert M. A.

AU - Swinkels, Ben M.

AU - ten Berg, Jurriën M.

AU - van der Kley, Frank

AU - Schalij, Martin J.

AU - Baan, Jan

AU - Cocchieri, Ricardo

AU - Brueren, Guus R. G.

AU - van Straten, Albert H. M.

AU - den Heijer, Peter

AU - Bentala, Mohamed

AU - van Ommen, Vincent

AU - Kluin, Jolanda

AU - Stella, Pieter R.

AU - Prins, Martin H.

AU - Maessen, Jos G.

AU - Prinzen, Frits W.

PY - 2012

Y1 - 2012

N2 - Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interquartile range, 253-725) days in patients without LBBB (P=0.90). All cause mortality was 37.8% (n=88) in patients with LBBB and 24.0% (n=107) patients without LBBB (P=0.002). By multivariate regression analysis, indepedent predictors of all-cause mortality were TAVI-induced LBBB (hazard ratio [HR], 1.54; condifence interval [CI], 1.12-2.10), chronic obstructive lung disease (HR, 1.56; CI, 1.15-2.10), female sex (HR, 1.39; CI, 1.04-1.85), left ventricular ejection fraction <= 50% (HR, 1.38; CI, 1.02-1.86), and baseline creatinine (HR, 1.32; CI, 1.19-1.43). LBBB was more frequent after implantation of the Medtronic Core Valve System than after Edwards SAPIEN implantation (51.1% and 12.0%, respectively; P <0.001), but device type did not influence the mortality risk of TAVI-induced LBBB. Conclusions-All-cause mortality after TAVI is higher in patients who develop LBBB than in patients who do not. TAVI-induced LBBB is an independent predictor of mortality. (Circulation. 2012;126:720-728.)

AB - Background-Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe aortic stenosis. Although 30% to 50% of patients develop new left bundle-branch block (LBBB), its effect on clinical outcome is unclear. Methods and Results-Data were collected in a multicenter registry encompassing TAVI patients from 2005 until 2010. The all-cause mortality rate at follow-up was compared between patients who did not develop new LBBB. Of 679 patients analyzed, 387 (57.0%) underwent TAVI wih the Medtronic CoreValve System and 292 (43.0%) with the Edwards SAPIEN valve. A total of 233 patients (34.3%) developed new LBBB. Median follow-up was 449.5 (interquartiel range, 174-834) days in patients with and 450 (interquartile range, 253-725) days in patients without LBBB (P=0.90). All cause mortality was 37.8% (n=88) in patients with LBBB and 24.0% (n=107) patients without LBBB (P=0.002). By multivariate regression analysis, indepedent predictors of all-cause mortality were TAVI-induced LBBB (hazard ratio [HR], 1.54; condifence interval [CI], 1.12-2.10), chronic obstructive lung disease (HR, 1.56; CI, 1.15-2.10), female sex (HR, 1.39; CI, 1.04-1.85), left ventricular ejection fraction <= 50% (HR, 1.38; CI, 1.02-1.86), and baseline creatinine (HR, 1.32; CI, 1.19-1.43). LBBB was more frequent after implantation of the Medtronic Core Valve System than after Edwards SAPIEN implantation (51.1% and 12.0%, respectively; P <0.001), but device type did not influence the mortality risk of TAVI-induced LBBB. Conclusions-All-cause mortality after TAVI is higher in patients who develop LBBB than in patients who do not. TAVI-induced LBBB is an independent predictor of mortality. (Circulation. 2012;126:720-728.)

U2 - 10.1161/CIRCULATIONAHA.112.101055

DO - 10.1161/CIRCULATIONAHA.112.101055

M3 - Article

C2 - 22791865

VL - 126

SP - 720

EP - 728

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 6

ER -

ID: 1764739