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Late-life depression, allostatic load, and risk of dementia : The AGES-Reykjavik study. / Twait, Emma L.; Basten, Maartje; Gerritsen, Lotte et al.
In: Psychoneuroendocrinology, Vol. 148, 105975, 01.02.2023.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Late-life depression, allostatic load, and risk of dementia
T2 - The AGES-Reykjavik study
AU - Twait, Emma L.
AU - Basten, Maartje
AU - Gerritsen, Lotte
AU - Gudnason, Vilmundur
AU - Launer, Lenore J.
AU - Geerlings, Mirjam I.
N1 - Funding Information: The AGES-Reykjavik study was funded by the Icelandic Heart Association, National Institute of Aging contracts (N01-AG-12100 and HHSN271201200022C) and Althingi (the Icelandic Parliament). This study was supported by a grant from Alzheimer Nederland (WE.03-2017-06). Publisher Copyright: © 2022
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Background: The current study aimed to assess if the relation between depression and dementia could be explained by allostatic load (AL) profiles, as well as assessing their risk on incident all-cause dementia, Alzheimer's disease (AD), and non-AD dementias. Methods: The study included individuals without dementia at baseline from the population-based AGES-Reykjavik Study. Depressive symptoms assessed with the Geriatric Depression Scale-15 and AL markers were collected at baseline. Latent profile analysis (LPA) was performed on the AL markers. Incident dementia was measured during 12-years of follow-up. Cox regressions adjusted for AL profiles were performed to evaluate if AL could explain the relation between depressive symptoms and incident dementia. Additional Cox regressions exploring the interaction with depressive symptoms and AL profiles were also performed. Results: LPA revealed four profiles based on AL factors: ‘Low cardiovascular dysregulation’ (43 %), ‘Average’ (42 % prevalence), ‘High cardiovascular dysregulation’ (11 %), and ‘Multisystem dysregulation’ (4 %). Cox regression analyses found an increased risk for dementia in the ‘Multisystem dysregulation’ group (HR 1.72; 95 % CI 1.26–2.33), as well as for AD (HR 1.75; 95 % CI: 1.12–2.71) and non-AD dementias (HR 1.87; 95 % CI: 1.23–2.84). AL profiles did not mediate the risk of all-cause dementia with depressive symptoms; however, there was evidence of additive interaction with depressive symptoms and the ‘Multisystem dysregulation’ profile and all-cause dementia (RERI 0.15; 95 % CI 0.03–0.26). Conclusion: AL profiles and depressive symptoms were independently related to dementia. Individuals with multisystem dysregulation could be more susceptible to the negative effects of depressive symptomology on incident dementia.
AB - Background: The current study aimed to assess if the relation between depression and dementia could be explained by allostatic load (AL) profiles, as well as assessing their risk on incident all-cause dementia, Alzheimer's disease (AD), and non-AD dementias. Methods: The study included individuals without dementia at baseline from the population-based AGES-Reykjavik Study. Depressive symptoms assessed with the Geriatric Depression Scale-15 and AL markers were collected at baseline. Latent profile analysis (LPA) was performed on the AL markers. Incident dementia was measured during 12-years of follow-up. Cox regressions adjusted for AL profiles were performed to evaluate if AL could explain the relation between depressive symptoms and incident dementia. Additional Cox regressions exploring the interaction with depressive symptoms and AL profiles were also performed. Results: LPA revealed four profiles based on AL factors: ‘Low cardiovascular dysregulation’ (43 %), ‘Average’ (42 % prevalence), ‘High cardiovascular dysregulation’ (11 %), and ‘Multisystem dysregulation’ (4 %). Cox regression analyses found an increased risk for dementia in the ‘Multisystem dysregulation’ group (HR 1.72; 95 % CI 1.26–2.33), as well as for AD (HR 1.75; 95 % CI: 1.12–2.71) and non-AD dementias (HR 1.87; 95 % CI: 1.23–2.84). AL profiles did not mediate the risk of all-cause dementia with depressive symptoms; however, there was evidence of additive interaction with depressive symptoms and the ‘Multisystem dysregulation’ profile and all-cause dementia (RERI 0.15; 95 % CI 0.03–0.26). Conclusion: AL profiles and depressive symptoms were independently related to dementia. Individuals with multisystem dysregulation could be more susceptible to the negative effects of depressive symptomology on incident dementia.
KW - Allostatic load
KW - Cluster analysis
KW - Dementia
KW - Depression
UR - http://www.scopus.com/inward/record.url?scp=85142314308&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2022.105975
DO - 10.1016/j.psyneuen.2022.105975
M3 - Article
C2 - 36423561
VL - 148
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
M1 - 105975
ER -
ID: 27501480