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Intraplaque hemorrhage in cardiac allograft vasculopathy. / Castellani, C.; Angelini, A.; de Boer, O. J.; van der Loos, C. M.; Fedrigo, M.; Frigo, A. C.; Meijer-Jorna, L. B.; Li, X.; Ploegmakers, H. J. P.; Tona, F.; Feltrin, G.; Gerosa, G.; Valente, M.; Thiene, G.; van der Wal, A. C.

In: American journal of transplantation, Vol. 14, No. 1, 2014, p. 184-192.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Castellani, C, Angelini, A, de Boer, OJ, van der Loos, CM, Fedrigo, M, Frigo, AC, Meijer-Jorna, LB, Li, X, Ploegmakers, HJP, Tona, F, Feltrin, G, Gerosa, G, Valente, M, Thiene, G & van der Wal, AC 2014, 'Intraplaque hemorrhage in cardiac allograft vasculopathy', American journal of transplantation, vol. 14, no. 1, pp. 184-192. https://doi.org/10.1111/ajt.12517

APA

Castellani, C., Angelini, A., de Boer, O. J., van der Loos, C. M., Fedrigo, M., Frigo, A. C., Meijer-Jorna, L. B., Li, X., Ploegmakers, H. J. P., Tona, F., Feltrin, G., Gerosa, G., Valente, M., Thiene, G., & van der Wal, A. C. (2014). Intraplaque hemorrhage in cardiac allograft vasculopathy. American journal of transplantation, 14(1), 184-192. https://doi.org/10.1111/ajt.12517

Vancouver

Castellani C, Angelini A, de Boer OJ, van der Loos CM, Fedrigo M, Frigo AC et al. Intraplaque hemorrhage in cardiac allograft vasculopathy. American journal of transplantation. 2014;14(1):184-192. https://doi.org/10.1111/ajt.12517

Author

Castellani, C. ; Angelini, A. ; de Boer, O. J. ; van der Loos, C. M. ; Fedrigo, M. ; Frigo, A. C. ; Meijer-Jorna, L. B. ; Li, X. ; Ploegmakers, H. J. P. ; Tona, F. ; Feltrin, G. ; Gerosa, G. ; Valente, M. ; Thiene, G. ; van der Wal, A. C. / Intraplaque hemorrhage in cardiac allograft vasculopathy. In: American journal of transplantation. 2014 ; Vol. 14, No. 1. pp. 184-192.

BibTeX

@article{c5c9c248c8554fa6886174f2e864a5a8,
title = "Intraplaque hemorrhage in cardiac allograft vasculopathy",
abstract = "Plaque hemorrhage, inflammation and microvessel density are key determinants of plaque vulnerability in native coronary atherosclerosis (ATS). This study investigates the role of intraplaque hemorrhage (IPH) and its relation with inflammation and microvessels in cardiac allograft vasculopathy (CAV) in posttransplanted patients. Seventy coronary plaques were obtained from 12 patients who died because of CAV. For each patient we collected both native heart and the allograft, at the time of transplantation and autopsy, respectively. Intralesion inflammation, microvessels and IPH were assessed semi-quantitatively. IPH was observed in 21/35 (60%) CAV lesions and in 8/35 (22.9%) native ATS plaques, with a strong association between fibrocellular lesions and IPH (p = 0.0142). Microvessels were detected in 26/35 (74.3%) of CAV lesions with perivascular leakage as sign of endothelial damage in 18/26 (69.2%). IPH was strongly associated with microvessels (p < 0.0001). Inflammation was present in 31/35 (88.6%) of CAV lesions. CAV IPH+ lesions were characterized by presence of both fresh and old hemorrhage in 12/21 (57.1%). IPH, associated with microvessel damage and inflammation, is an important feature of CAV. Fresh and old intralesion hemorrhage suggests ongoing remodeling processes promoting the lesion progression and vulnerability",
author = "C. Castellani and A. Angelini and {de Boer}, {O. J.} and {van der Loos}, {C. M.} and M. Fedrigo and Frigo, {A. C.} and Meijer-Jorna, {L. B.} and X. Li and Ploegmakers, {H. J. P.} and F. Tona and G. Feltrin and G. Gerosa and M. Valente and G. Thiene and {van der Wal}, {A. C.}",
year = "2014",
doi = "10.1111/ajt.12517",
language = "English",
volume = "14",
pages = "184--192",
journal = "American journal of transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Intraplaque hemorrhage in cardiac allograft vasculopathy

AU - Castellani, C.

AU - Angelini, A.

AU - de Boer, O. J.

AU - van der Loos, C. M.

AU - Fedrigo, M.

AU - Frigo, A. C.

AU - Meijer-Jorna, L. B.

AU - Li, X.

AU - Ploegmakers, H. J. P.

AU - Tona, F.

AU - Feltrin, G.

AU - Gerosa, G.

AU - Valente, M.

AU - Thiene, G.

AU - van der Wal, A. C.

PY - 2014

Y1 - 2014

N2 - Plaque hemorrhage, inflammation and microvessel density are key determinants of plaque vulnerability in native coronary atherosclerosis (ATS). This study investigates the role of intraplaque hemorrhage (IPH) and its relation with inflammation and microvessels in cardiac allograft vasculopathy (CAV) in posttransplanted patients. Seventy coronary plaques were obtained from 12 patients who died because of CAV. For each patient we collected both native heart and the allograft, at the time of transplantation and autopsy, respectively. Intralesion inflammation, microvessels and IPH were assessed semi-quantitatively. IPH was observed in 21/35 (60%) CAV lesions and in 8/35 (22.9%) native ATS plaques, with a strong association between fibrocellular lesions and IPH (p = 0.0142). Microvessels were detected in 26/35 (74.3%) of CAV lesions with perivascular leakage as sign of endothelial damage in 18/26 (69.2%). IPH was strongly associated with microvessels (p < 0.0001). Inflammation was present in 31/35 (88.6%) of CAV lesions. CAV IPH+ lesions were characterized by presence of both fresh and old hemorrhage in 12/21 (57.1%). IPH, associated with microvessel damage and inflammation, is an important feature of CAV. Fresh and old intralesion hemorrhage suggests ongoing remodeling processes promoting the lesion progression and vulnerability

AB - Plaque hemorrhage, inflammation and microvessel density are key determinants of plaque vulnerability in native coronary atherosclerosis (ATS). This study investigates the role of intraplaque hemorrhage (IPH) and its relation with inflammation and microvessels in cardiac allograft vasculopathy (CAV) in posttransplanted patients. Seventy coronary plaques were obtained from 12 patients who died because of CAV. For each patient we collected both native heart and the allograft, at the time of transplantation and autopsy, respectively. Intralesion inflammation, microvessels and IPH were assessed semi-quantitatively. IPH was observed in 21/35 (60%) CAV lesions and in 8/35 (22.9%) native ATS plaques, with a strong association between fibrocellular lesions and IPH (p = 0.0142). Microvessels were detected in 26/35 (74.3%) of CAV lesions with perivascular leakage as sign of endothelial damage in 18/26 (69.2%). IPH was strongly associated with microvessels (p < 0.0001). Inflammation was present in 31/35 (88.6%) of CAV lesions. CAV IPH+ lesions were characterized by presence of both fresh and old hemorrhage in 12/21 (57.1%). IPH, associated with microvessel damage and inflammation, is an important feature of CAV. Fresh and old intralesion hemorrhage suggests ongoing remodeling processes promoting the lesion progression and vulnerability

U2 - 10.1111/ajt.12517

DO - 10.1111/ajt.12517

M3 - Article

C2 - 24354875

VL - 14

SP - 184

EP - 192

JO - American journal of transplantation

JF - American journal of transplantation

SN - 1600-6135

IS - 1

ER -

ID: 2278473