Research output: Contribution to journal › Article › Academic › peer-review
Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia. / Doldersum, E; van Zijl, J C; Beudel, M et al.
In: Clinical neurophysiology, Vol. 130, No. 8, 2019, p. 1351-1357.Research output: Contribution to journal › Article › Academic › peer-review
}
TY - JOUR
T1 - Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia
AU - Doldersum, E
AU - van Zijl, J C
AU - Beudel, M
AU - Eggink, H
AU - Brandsma, R
AU - Piña-Fuentes, D
AU - van Egmond, M E
AU - Oterdoom, D L M
AU - van Dijk, J M C
AU - Elting, J W J
AU - Tijssen, M A J
N1 - Copyright © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPi-DBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients. Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre- and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre- and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4–12 Hz) and beta band (13–30 Hz) peak coherences were studied. Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3–10), TWSTRS: 22%, median 6.8 (IQR 4–9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit. Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice.
AB - Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPi-DBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients. Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre- and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre- and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4–12 Hz) and beta band (13–30 Hz) peak coherences were studied. Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3–10), TWSTRS: 22%, median 6.8 (IQR 4–9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit. Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice.
KW - Adult
KW - Deep Brain Stimulation/methods
KW - Dystonia/diagnosis
KW - Electroencephalography/methods
KW - Electromyography/methods
KW - Female
KW - Globus Pallidus/physiopathology
KW - Humans
KW - Male
KW - Middle Aged
KW - Motor Cortex/physiopathology
KW - Muscle, Skeletal/physiopathology
UR - http://www.scopus.com/inward/record.url?scp=85067181688&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2019.04.717
DO - 10.1016/j.clinph.2019.04.717
M3 - Article
C2 - 31207566
VL - 130
SP - 1351
EP - 1357
JO - Clinical neurophysiology
JF - Clinical neurophysiology
SN - 1388-2457
IS - 8
ER -
ID: 6606785