Standard

Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia. / Doldersum, E; van Zijl, J C; Beudel, M et al.

In: Clinical neurophysiology, Vol. 130, No. 8, 2019, p. 1351-1357.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Doldersum, E, van Zijl, JC, Beudel, M, Eggink, H, Brandsma, R, Piña-Fuentes, D, van Egmond, ME, Oterdoom, DLM, van Dijk, JMC, Elting, JWJ & Tijssen, MAJ 2019, 'Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia', Clinical neurophysiology, vol. 130, no. 8, pp. 1351-1357. https://doi.org/10.1016/j.clinph.2019.04.717

APA

Doldersum, E., van Zijl, J. C., Beudel, M., Eggink, H., Brandsma, R., Piña-Fuentes, D., van Egmond, M. E., Oterdoom, D. L. M., van Dijk, J. M. C., Elting, J. W. J., & Tijssen, M. A. J. (2019). Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia. Clinical neurophysiology, 130(8), 1351-1357. https://doi.org/10.1016/j.clinph.2019.04.717

Vancouver

Doldersum E, van Zijl JC, Beudel M, Eggink H, Brandsma R, Piña-Fuentes D et al. Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia. Clinical neurophysiology. 2019;130(8):1351-1357. doi: 10.1016/j.clinph.2019.04.717

Author

Doldersum, E ; van Zijl, J C ; Beudel, M et al. / Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia. In: Clinical neurophysiology. 2019 ; Vol. 130, No. 8. pp. 1351-1357.

BibTeX

@article{d6259d0f33744617ba390ad844b11ca1,
title = "Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia",
abstract = "Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPi-DBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients. Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre- and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre- and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4–12 Hz) and beta band (13–30 Hz) peak coherences were studied. Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3–10), TWSTRS: 22%, median 6.8 (IQR 4–9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit. Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice.",
keywords = "Adult, Deep Brain Stimulation/methods, Dystonia/diagnosis, Electroencephalography/methods, Electromyography/methods, Female, Globus Pallidus/physiopathology, Humans, Male, Middle Aged, Motor Cortex/physiopathology, Muscle, Skeletal/physiopathology",
author = "E Doldersum and {van Zijl}, {J C} and M Beudel and H Eggink and R Brandsma and D Pi{\~n}a-Fuentes and {van Egmond}, {M E} and Oterdoom, {D L M} and {van Dijk}, {J M C} and Elting, {J W J} and Tijssen, {M A J}",
note = "Copyright {\textcopyright} 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.",
year = "2019",
doi = "10.1016/j.clinph.2019.04.717",
language = "English",
volume = "130",
pages = "1351--1357",
journal = "Clinical neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

AU - Doldersum, E

AU - van Zijl, J C

AU - Beudel, M

AU - Eggink, H

AU - Brandsma, R

AU - Piña-Fuentes, D

AU - van Egmond, M E

AU - Oterdoom, D L M

AU - van Dijk, J M C

AU - Elting, J W J

AU - Tijssen, M A J

N1 - Copyright © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPi-DBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients. Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre- and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre- and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4–12 Hz) and beta band (13–30 Hz) peak coherences were studied. Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3–10), TWSTRS: 22%, median 6.8 (IQR 4–9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit. Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice.

AB - Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPi-DBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients. Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre- and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre- and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4–12 Hz) and beta band (13–30 Hz) peak coherences were studied. Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3–10), TWSTRS: 22%, median 6.8 (IQR 4–9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit. Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice.

KW - Adult

KW - Deep Brain Stimulation/methods

KW - Dystonia/diagnosis

KW - Electroencephalography/methods

KW - Electromyography/methods

KW - Female

KW - Globus Pallidus/physiopathology

KW - Humans

KW - Male

KW - Middle Aged

KW - Motor Cortex/physiopathology

KW - Muscle, Skeletal/physiopathology

UR - http://www.scopus.com/inward/record.url?scp=85067181688&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2019.04.717

DO - 10.1016/j.clinph.2019.04.717

M3 - Article

C2 - 31207566

VL - 130

SP - 1351

EP - 1357

JO - Clinical neurophysiology

JF - Clinical neurophysiology

SN - 1388-2457

IS - 8

ER -

ID: 6606785