Standard

Indeterminate pediatric acute liver failure : Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022. / Lexmond, Willem S.; de Meijer, Vincent E.; Scheenstra, René et al.

In: United European gastroenterology journal, Vol. 10, No. 8, 10.2022, p. 795-804.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Lexmond, WS, de Meijer, VE, Scheenstra, R, Bontemps, STH, Duiker, EW, Schölvinck, EH, Zhou, X, von Eije, KJ, Reyntjens, KMEM, Verkade, HJ, Porte, RJ & de Kleine, RH 2022, 'Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022', United European gastroenterology journal, vol. 10, no. 8, pp. 795-804. https://doi.org/10.1002/ueg2.12269

APA

Lexmond, W. S., de Meijer, V. E., Scheenstra, R., Bontemps, S. T. H., Duiker, E. W., Schölvinck, E. H., Zhou, X., von Eije, K. J., Reyntjens, K. M. E. M., Verkade, H. J., Porte, R. J., & de Kleine, R. H. (2022). Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022. United European gastroenterology journal, 10(8), 795-804. https://doi.org/10.1002/ueg2.12269

Vancouver

Lexmond WS, de Meijer VE, Scheenstra R, Bontemps STH, Duiker EW, Schölvinck EH et al. Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022. United European gastroenterology journal. 2022 Oct;10(8):795-804. Epub 2022. doi: 10.1002/ueg2.12269

Author

Lexmond, Willem S. ; de Meijer, Vincent E. ; Scheenstra, René et al. / Indeterminate pediatric acute liver failure : Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022. In: United European gastroenterology journal. 2022 ; Vol. 10, No. 8. pp. 795-804.

BibTeX

@article{b1d7e2b0735a4fa88e20e456f62e6de5,
title = "Indeterminate pediatric acute liver failure: Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022",
abstract = "There is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeterminate acute liver failure. Four children underwent liver transplantation, one spontaneously recovered. Here we delineate the clinical course and comprehensive diagnostic workup of these patients. Three of five patients showed a gradual decline of liver synthetic function and had mild neurological symptoms. Their clinical and histological findings were consistent with hepatitis. These three patients all had a past SARS-CoV-2 infection and two of them were positive for adenovirus DNA. The other two patients presented with advanced liver failure and encephalopathy and underwent dialysis as a bridge to transplantation. One of these children spontaneously recovered. We discuss this cluster of patients in the context of the currently elevated incidence of severe acute hepatitis in children.",
keywords = "acute liver failure, adenovirus, hepatitis, liver transplantation",
author = "Lexmond, {Willem S.} and {de Meijer}, {Vincent E.} and Ren{\'e} Scheenstra and Bontemps, {Sander T. H.} and Duiker, {Evelien W.} and Sch{\"o}lvinck, {Elisabeth H.} and Xuewei Zhou and {von Eije}, {Karin J.} and Reyntjens, {Koen M. E. M.} and Verkade, {Henkjan J.} and Porte, {Robert J.} and {de Kleine}, {Ruben H.}",
note = "Funding Information: We thank the members of the working group on Acute Liver Failure from the European Reference Network for hepatological diseases (ERN RARE-LIVER) for helpful discussions on the emerging incidence of acute severe hepatitis in children. Publisher Copyright: {\textcopyright} 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.",
year = "2022",
month = oct,
doi = "10.1002/ueg2.12269",
language = "English",
volume = "10",
pages = "795--804",
journal = "United European gastroenterology journal",
issn = "2050-6406",
publisher = "SAGE Publications Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Indeterminate pediatric acute liver failure

T2 - Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022

AU - Lexmond, Willem S.

AU - de Meijer, Vincent E.

AU - Scheenstra, René

AU - Bontemps, Sander T. H.

AU - Duiker, Evelien W.

AU - Schölvinck, Elisabeth H.

AU - Zhou, Xuewei

AU - von Eije, Karin J.

AU - Reyntjens, Koen M. E. M.

AU - Verkade, Henkjan J.

AU - Porte, Robert J.

AU - de Kleine, Ruben H.

N1 - Funding Information: We thank the members of the working group on Acute Liver Failure from the European Reference Network for hepatological diseases (ERN RARE-LIVER) for helpful discussions on the emerging incidence of acute severe hepatitis in children. Publisher Copyright: © 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.

PY - 2022/10

Y1 - 2022/10

N2 - There is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeterminate acute liver failure. Four children underwent liver transplantation, one spontaneously recovered. Here we delineate the clinical course and comprehensive diagnostic workup of these patients. Three of five patients showed a gradual decline of liver synthetic function and had mild neurological symptoms. Their clinical and histological findings were consistent with hepatitis. These three patients all had a past SARS-CoV-2 infection and two of them were positive for adenovirus DNA. The other two patients presented with advanced liver failure and encephalopathy and underwent dialysis as a bridge to transplantation. One of these children spontaneously recovered. We discuss this cluster of patients in the context of the currently elevated incidence of severe acute hepatitis in children.

AB - There is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeterminate acute liver failure. Four children underwent liver transplantation, one spontaneously recovered. Here we delineate the clinical course and comprehensive diagnostic workup of these patients. Three of five patients showed a gradual decline of liver synthetic function and had mild neurological symptoms. Their clinical and histological findings were consistent with hepatitis. These three patients all had a past SARS-CoV-2 infection and two of them were positive for adenovirus DNA. The other two patients presented with advanced liver failure and encephalopathy and underwent dialysis as a bridge to transplantation. One of these children spontaneously recovered. We discuss this cluster of patients in the context of the currently elevated incidence of severe acute hepatitis in children.

KW - acute liver failure

KW - adenovirus

KW - hepatitis

KW - liver transplantation

UR - http://www.scopus.com/inward/record.url?scp=85133142911&partnerID=8YFLogxK

U2 - 10.1002/ueg2.12269

DO - 10.1002/ueg2.12269

M3 - Article

C2 - 35773246

VL - 10

SP - 795

EP - 804

JO - United European gastroenterology journal

JF - United European gastroenterology journal

SN - 2050-6406

IS - 8

ER -

ID: 24880075