Indeterminate pediatric acute liver failure : Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022. / Lexmond, Willem S.; de Meijer, Vincent E.; Scheenstra, René et al.
In: United European gastroenterology journal, Vol. 10, No. 8, 10.2022, p. 795-804.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Indeterminate pediatric acute liver failure
T2 - Clinical characteristics of a temporal cluster of five children in the Netherlands in the spring of 2022
AU - Lexmond, Willem S.
AU - de Meijer, Vincent E.
AU - Scheenstra, René
AU - Bontemps, Sander T. H.
AU - Duiker, Evelien W.
AU - Schölvinck, Elisabeth H.
AU - Zhou, Xuewei
AU - von Eije, Karin J.
AU - Reyntjens, Koen M. E. M.
AU - Verkade, Henkjan J.
AU - Porte, Robert J.
AU - de Kleine, Ruben H.
N1 - Funding Information: We thank the members of the working group on Acute Liver Failure from the European Reference Network for hepatological diseases (ERN RARE-LIVER) for helpful discussions on the emerging incidence of acute severe hepatitis in children. Publisher Copyright: © 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.
PY - 2022/10
Y1 - 2022/10
N2 - There is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeterminate acute liver failure. Four children underwent liver transplantation, one spontaneously recovered. Here we delineate the clinical course and comprehensive diagnostic workup of these patients. Three of five patients showed a gradual decline of liver synthetic function and had mild neurological symptoms. Their clinical and histological findings were consistent with hepatitis. These three patients all had a past SARS-CoV-2 infection and two of them were positive for adenovirus DNA. The other two patients presented with advanced liver failure and encephalopathy and underwent dialysis as a bridge to transplantation. One of these children spontaneously recovered. We discuss this cluster of patients in the context of the currently elevated incidence of severe acute hepatitis in children.
AB - There is increasing global concern of severe acute hepatitis of unknown etiology in young children. In early 2022, our center for liver transplantation in the Netherlands treated five children who presented in short succession with indeterminate acute liver failure. Four children underwent liver transplantation, one spontaneously recovered. Here we delineate the clinical course and comprehensive diagnostic workup of these patients. Three of five patients showed a gradual decline of liver synthetic function and had mild neurological symptoms. Their clinical and histological findings were consistent with hepatitis. These three patients all had a past SARS-CoV-2 infection and two of them were positive for adenovirus DNA. The other two patients presented with advanced liver failure and encephalopathy and underwent dialysis as a bridge to transplantation. One of these children spontaneously recovered. We discuss this cluster of patients in the context of the currently elevated incidence of severe acute hepatitis in children.
KW - acute liver failure
KW - adenovirus
KW - hepatitis
KW - liver transplantation
UR - http://www.scopus.com/inward/record.url?scp=85133142911&partnerID=8YFLogxK
U2 - 10.1002/ueg2.12269
DO - 10.1002/ueg2.12269
M3 - Article
C2 - 35773246
VL - 10
SP - 795
EP - 804
JO - United European gastroenterology journal
JF - United European gastroenterology journal
SN - 2050-6406
IS - 8
ER -
ID: 24880075