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In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep. / Kluin, Jolanda; Talacua, Hanna; Smits, Anthal I. P. M.; Emmert, Maximilian Y.; Brugmans, Marieke C. P.; Fioretta, Emanuela S.; Dijkman, Petra E.; Söntjens, Serge H. M.; Duijvelshoff, Renée; Dekker, Sylvia; Janssen-van den Broek, Marloes W. J. T.; Lintas, Valentina; Vink, Aryan; Hoerstrup, Simon P.; Janssen, Henk M.; Dankers, Patricia Y. W.; Baaijens, Frank P. T.; Bouten, Carlijn V. C.

In: Biomaterials, Vol. 125, 2017, p. 101-117.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Kluin, J, Talacua, H, Smits, AIPM, Emmert, MY, Brugmans, MCP, Fioretta, ES, Dijkman, PE, Söntjens, SHM, Duijvelshoff, R, Dekker, S, Janssen-van den Broek, MWJT, Lintas, V, Vink, A, Hoerstrup, SP, Janssen, HM, Dankers, PYW, Baaijens, FPT & Bouten, CVC 2017, 'In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep', Biomaterials, vol. 125, pp. 101-117. https://doi.org/10.1016/j.biomaterials.2017.02.007

APA

Kluin, J., Talacua, H., Smits, A. I. P. M., Emmert, M. Y., Brugmans, M. C. P., Fioretta, E. S., Dijkman, P. E., Söntjens, S. H. M., Duijvelshoff, R., Dekker, S., Janssen-van den Broek, M. W. J. T., Lintas, V., Vink, A., Hoerstrup, S. P., Janssen, H. M., Dankers, P. Y. W., Baaijens, F. P. T., & Bouten, C. V. C. (2017). In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep. Biomaterials, 125, 101-117. https://doi.org/10.1016/j.biomaterials.2017.02.007

Vancouver

Author

Kluin, Jolanda ; Talacua, Hanna ; Smits, Anthal I. P. M. ; Emmert, Maximilian Y. ; Brugmans, Marieke C. P. ; Fioretta, Emanuela S. ; Dijkman, Petra E. ; Söntjens, Serge H. M. ; Duijvelshoff, Renée ; Dekker, Sylvia ; Janssen-van den Broek, Marloes W. J. T. ; Lintas, Valentina ; Vink, Aryan ; Hoerstrup, Simon P. ; Janssen, Henk M. ; Dankers, Patricia Y. W. ; Baaijens, Frank P. T. ; Bouten, Carlijn V. C. / In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep. In: Biomaterials. 2017 ; Vol. 125. pp. 101-117.

BibTeX

@article{345ae6f574164b0f8e507a6d44325bef,
title = "In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep",
abstract = "The creation of a living heart valve is a much-wanted alternative for current valve prostheses that suffer from limited durability and thromboembolic complications. Current strategies to create such valves, however, require the use of cells for in vitro culture, or decellularized human- or animal-derived donor tissue for in situ engineering. Here, we propose and demonstrate proof-of-concept of in situ heart valve tissue engineering using a synthetic approach, in which a cell-free, slow degrading elastomeric valvular implant is populated by endogenous cells to form new valvular tissue inside the heart. We designed a fibrous valvular scaffold, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix. Orthotopic implantations as pulmonary valve in sheep demonstrated sustained functionality up to 12 months, while the implant was gradually replaced by a layered collagen and elastic matrix in pace with cell-driven polymer resorption. Our results offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures",
author = "Jolanda Kluin and Hanna Talacua and Smits, {Anthal I. P. M.} and Emmert, {Maximilian Y.} and Brugmans, {Marieke C. P.} and Fioretta, {Emanuela S.} and Dijkman, {Petra E.} and S{\"o}ntjens, {Serge H. M.} and Ren{\'e}e Duijvelshoff and Sylvia Dekker and {Janssen-van den Broek}, {Marloes W. J. T.} and Valentina Lintas and Aryan Vink and Hoerstrup, {Simon P.} and Janssen, {Henk M.} and Dankers, {Patricia Y. W.} and Baaijens, {Frank P. T.} and Bouten, {Carlijn V. C.}",
year = "2017",
doi = "10.1016/j.biomaterials.2017.02.007",
language = "English",
volume = "125",
pages = "101--117",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - In situ heart valve tissue engineering using a bioresorbable elastomeric implant - From material design to 12 months follow-up in sheep

AU - Kluin, Jolanda

AU - Talacua, Hanna

AU - Smits, Anthal I. P. M.

AU - Emmert, Maximilian Y.

AU - Brugmans, Marieke C. P.

AU - Fioretta, Emanuela S.

AU - Dijkman, Petra E.

AU - Söntjens, Serge H. M.

AU - Duijvelshoff, Renée

AU - Dekker, Sylvia

AU - Janssen-van den Broek, Marloes W. J. T.

AU - Lintas, Valentina

AU - Vink, Aryan

AU - Hoerstrup, Simon P.

AU - Janssen, Henk M.

AU - Dankers, Patricia Y. W.

AU - Baaijens, Frank P. T.

AU - Bouten, Carlijn V. C.

PY - 2017

Y1 - 2017

N2 - The creation of a living heart valve is a much-wanted alternative for current valve prostheses that suffer from limited durability and thromboembolic complications. Current strategies to create such valves, however, require the use of cells for in vitro culture, or decellularized human- or animal-derived donor tissue for in situ engineering. Here, we propose and demonstrate proof-of-concept of in situ heart valve tissue engineering using a synthetic approach, in which a cell-free, slow degrading elastomeric valvular implant is populated by endogenous cells to form new valvular tissue inside the heart. We designed a fibrous valvular scaffold, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix. Orthotopic implantations as pulmonary valve in sheep demonstrated sustained functionality up to 12 months, while the implant was gradually replaced by a layered collagen and elastic matrix in pace with cell-driven polymer resorption. Our results offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures

AB - The creation of a living heart valve is a much-wanted alternative for current valve prostheses that suffer from limited durability and thromboembolic complications. Current strategies to create such valves, however, require the use of cells for in vitro culture, or decellularized human- or animal-derived donor tissue for in situ engineering. Here, we propose and demonstrate proof-of-concept of in situ heart valve tissue engineering using a synthetic approach, in which a cell-free, slow degrading elastomeric valvular implant is populated by endogenous cells to form new valvular tissue inside the heart. We designed a fibrous valvular scaffold, fabricated from a novel supramolecular elastomer, that enables endogenous cells to enter and produce matrix. Orthotopic implantations as pulmonary valve in sheep demonstrated sustained functionality up to 12 months, while the implant was gradually replaced by a layered collagen and elastic matrix in pace with cell-driven polymer resorption. Our results offer new perspectives for endogenous heart valve replacement starting from a readily-available synthetic graft that is compatible with surgical and transcatheter implantation procedures

U2 - 10.1016/j.biomaterials.2017.02.007

DO - 10.1016/j.biomaterials.2017.02.007

M3 - Article

C2 - 28253994

VL - 125

SP - 101

EP - 117

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

ER -

ID: 3503761