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Impact of age, sex, and global function on normal aortic hemodynamics. / Scott, Michael B.; Huh, Hyungkyu; van Ooij, Pim et al.

In: Magnetic resonance in medicine, Vol. 84, No. 4, 01.10.2020, p. 2088-2102.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Scott, MB, Huh, H, van Ooij, P, Chen, V, Herrera, B, Elbaz, M, McCarthy, P, Malaisrie, SC, Carr, J, Fedak, PWM, Markl, M & Barker, AJ 2020, 'Impact of age, sex, and global function on normal aortic hemodynamics', Magnetic resonance in medicine, vol. 84, no. 4, pp. 2088-2102. https://doi.org/10.1002/mrm.28250

APA

Scott, M. B., Huh, H., van Ooij, P., Chen, V., Herrera, B., Elbaz, M., McCarthy, P., Malaisrie, S. C., Carr, J., Fedak, P. W. M., Markl, M., & Barker, A. J. (2020). Impact of age, sex, and global function on normal aortic hemodynamics. Magnetic resonance in medicine, 84(4), 2088-2102. https://doi.org/10.1002/mrm.28250

Vancouver

Scott MB, Huh H, van Ooij P, Chen V, Herrera B, Elbaz M et al. Impact of age, sex, and global function on normal aortic hemodynamics. Magnetic resonance in medicine. 2020 Oct 1;84(4):2088-2102. Epub 2020. doi: 10.1002/mrm.28250

Author

Scott, Michael B. ; Huh, Hyungkyu ; van Ooij, Pim et al. / Impact of age, sex, and global function on normal aortic hemodynamics. In: Magnetic resonance in medicine. 2020 ; Vol. 84, No. 4. pp. 2088-2102.

BibTeX

@article{9a8bbf10299143698a3ed9572a866b46,
title = "Impact of age, sex, and global function on normal aortic hemodynamics",
abstract = "Purpose: To examine the effects of age, sex, and left ventricular global function on velocity, helicity, and 3D wall shear stress (3D-WSS) in the aorta of N = 100 healthy controls. Methods: Fifty female and 50 male volunteers with no history of cardiovascular disease, with 10 volunteers per age group (18-30, 31-40, 41-50, 51-60, and 61-80 years) underwent aortic 4D-flow MRI. Quantification of systolic aortic peak velocity, helicity, and 3D-WSS distribution and the calculation of age group–averaged peak systolic velocity and 3D-WSS maps (“atlases”) were computed. Age-related and sex-related changes in peak velocity, helicity, and 3D-WSS were computed and correlated with standard metrics of left ventricular function derived from short-axis cine MRI. Results: No significant differences were found in peak systolic velocity or 3D-WSS based on sex except for the 18- to 30-year-old group (males 8% higher velocity volume and 3D-WSS surface area). Between successively older groups, systolic velocity decreased (13%, <1%, 7%, and 55% of the aorta volume) and 3D-WSS decreased (21%, 2%, 30%, and 62% of the aorta surface area). Mean velocity, mean 3D-3D-WSS, and median helicity increased with cardiac output (r = 0.27-0.43, all P <.01), and mean velocity and 3D-WSS decreased with increasing diameter (r > 0.35, P <.001). Arch and descending aorta systolic mean velocity, mean 3D-WSS, and median helicity increased with normalized left ventricular volumes: end diastolic volume (r = 0.31-0.37, P <.01), end systolic volume (r = 0.27-0.35, P <.01), and stroke volume (r = 0.28-0.35, P <.01). Conclusion: Healthy aortic hemodynamics are dependent on subject age, and correlate with vessel diameter and cardiac function.",
keywords = "4D flow MRI, aortic disease, flow imaging, healthy controls, hemodynamics",
author = "Scott, {Michael B.} and Hyungkyu Huh and {van Ooij}, Pim and Vincent Chen and Brenda Herrera and Mohammed Elbaz and Patrick McCarthy and Malaisrie, {S. Chris} and James Carr and Fedak, {Paul W. M.} and Michael Markl and Barker, {Alex J.}",
year = "2020",
month = oct,
day = "1",
doi = "10.1002/mrm.28250",
language = "English",
volume = "84",
pages = "2088--2102",
journal = "Magnetic resonance in medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Impact of age, sex, and global function on normal aortic hemodynamics

AU - Scott, Michael B.

AU - Huh, Hyungkyu

AU - van Ooij, Pim

AU - Chen, Vincent

AU - Herrera, Brenda

AU - Elbaz, Mohammed

AU - McCarthy, Patrick

AU - Malaisrie, S. Chris

AU - Carr, James

AU - Fedak, Paul W. M.

AU - Markl, Michael

AU - Barker, Alex J.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Purpose: To examine the effects of age, sex, and left ventricular global function on velocity, helicity, and 3D wall shear stress (3D-WSS) in the aorta of N = 100 healthy controls. Methods: Fifty female and 50 male volunteers with no history of cardiovascular disease, with 10 volunteers per age group (18-30, 31-40, 41-50, 51-60, and 61-80 years) underwent aortic 4D-flow MRI. Quantification of systolic aortic peak velocity, helicity, and 3D-WSS distribution and the calculation of age group–averaged peak systolic velocity and 3D-WSS maps (“atlases”) were computed. Age-related and sex-related changes in peak velocity, helicity, and 3D-WSS were computed and correlated with standard metrics of left ventricular function derived from short-axis cine MRI. Results: No significant differences were found in peak systolic velocity or 3D-WSS based on sex except for the 18- to 30-year-old group (males 8% higher velocity volume and 3D-WSS surface area). Between successively older groups, systolic velocity decreased (13%, <1%, 7%, and 55% of the aorta volume) and 3D-WSS decreased (21%, 2%, 30%, and 62% of the aorta surface area). Mean velocity, mean 3D-3D-WSS, and median helicity increased with cardiac output (r = 0.27-0.43, all P <.01), and mean velocity and 3D-WSS decreased with increasing diameter (r > 0.35, P <.001). Arch and descending aorta systolic mean velocity, mean 3D-WSS, and median helicity increased with normalized left ventricular volumes: end diastolic volume (r = 0.31-0.37, P <.01), end systolic volume (r = 0.27-0.35, P <.01), and stroke volume (r = 0.28-0.35, P <.01). Conclusion: Healthy aortic hemodynamics are dependent on subject age, and correlate with vessel diameter and cardiac function.

AB - Purpose: To examine the effects of age, sex, and left ventricular global function on velocity, helicity, and 3D wall shear stress (3D-WSS) in the aorta of N = 100 healthy controls. Methods: Fifty female and 50 male volunteers with no history of cardiovascular disease, with 10 volunteers per age group (18-30, 31-40, 41-50, 51-60, and 61-80 years) underwent aortic 4D-flow MRI. Quantification of systolic aortic peak velocity, helicity, and 3D-WSS distribution and the calculation of age group–averaged peak systolic velocity and 3D-WSS maps (“atlases”) were computed. Age-related and sex-related changes in peak velocity, helicity, and 3D-WSS were computed and correlated with standard metrics of left ventricular function derived from short-axis cine MRI. Results: No significant differences were found in peak systolic velocity or 3D-WSS based on sex except for the 18- to 30-year-old group (males 8% higher velocity volume and 3D-WSS surface area). Between successively older groups, systolic velocity decreased (13%, <1%, 7%, and 55% of the aorta volume) and 3D-WSS decreased (21%, 2%, 30%, and 62% of the aorta surface area). Mean velocity, mean 3D-3D-WSS, and median helicity increased with cardiac output (r = 0.27-0.43, all P <.01), and mean velocity and 3D-WSS decreased with increasing diameter (r > 0.35, P <.001). Arch and descending aorta systolic mean velocity, mean 3D-WSS, and median helicity increased with normalized left ventricular volumes: end diastolic volume (r = 0.31-0.37, P <.01), end systolic volume (r = 0.27-0.35, P <.01), and stroke volume (r = 0.28-0.35, P <.01). Conclusion: Healthy aortic hemodynamics are dependent on subject age, and correlate with vessel diameter and cardiac function.

KW - 4D flow MRI

KW - aortic disease

KW - flow imaging

KW - healthy controls

KW - hemodynamics

UR - http://www.scopus.com/inward/record.url?scp=85081332438&partnerID=8YFLogxK

U2 - 10.1002/mrm.28250

DO - 10.1002/mrm.28250

M3 - Article

C2 - 32162416

VL - 84

SP - 2088

EP - 2102

JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

SN - 0740-3194

IS - 4

ER -

ID: 11194675