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IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming. / Hoepel, Willianne; Allahverdiyeva, Sona; Harbiye, Haneen et al.

In: Journal of immunology (Baltimore, Md., Vol. 205, No. 12, 15.12.2020, p. 3400-3407.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Hoepel, W, Allahverdiyeva, S, Harbiye, H, de Taeye, SW, van der Ham, AJ, de Boer, L, Zaat, SAJ, van Weeghel, M, Baeten, DLP, Houtkooper, RH, Everts, B, Vidarsson, G & den Dunnen, J 2020, 'IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming', Journal of immunology (Baltimore, Md., vol. 205, no. 12, pp. 3400-3407. https://doi.org/10.4049/jimmunol.2000263

APA

Hoepel, W., Allahverdiyeva, S., Harbiye, H., de Taeye, S. W., van der Ham, A. J., de Boer, L., Zaat, S. A. J., van Weeghel, M., Baeten, D. L. P., Houtkooper, R. H., Everts, B., Vidarsson, G., & den Dunnen, J. (2020). IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming. Journal of immunology (Baltimore, Md., 205(12), 3400-3407. https://doi.org/10.4049/jimmunol.2000263

Vancouver

Hoepel W, Allahverdiyeva S, Harbiye H, de Taeye SW, van der Ham AJ, de Boer L et al. IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming. Journal of immunology (Baltimore, Md. 2020 Dec 15;205(12):3400-3407. Epub 2020. doi: 10.4049/jimmunol.2000263

Author

Hoepel, Willianne ; Allahverdiyeva, Sona ; Harbiye, Haneen et al. / IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming. In: Journal of immunology (Baltimore, Md. 2020 ; Vol. 205, No. 12. pp. 3400-3407.

BibTeX

@article{1d616d8c636b43c9886fc215911c9b31,
title = "IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming",
abstract = "IgG Abs are crucial for various immune functions, including neutralization, phagocytosis, and Ab-dependent cellular cytotoxicity. In this study, we identified another function of IgG by showing that IgG immune complexes elicit distinct cytokine profiles by human myeloid immune cells, which are dependent on FcgR activation by the different IgG subclasses. Using monoclonal IgG subclasses with identical Ag specificity, our data demonstrate that the production of Th17-inducing cytokines, such as TNF, IL-1b, and IL-23, is particularly dependent on IgG2, whereas type I IFN responses are controlled by IgG3, and IgG1 is able to regulate both. In addition, we identified that subclass-specific cytokine production is orchestrated at the posttranscriptional level through distinct glycolytic reprogramming of human myeloid immune cells. Combined, these data identify that IgG subclasses provide pathogen- and cell type-specific immunity through differential metabolic reprogramming by FcgRs. These findings may be relevant for future design of Ab-related therapies in the context of infectious diseases, chronic inflammation, and cancer.",
author = "Willianne Hoepel and Sona Allahverdiyeva and Haneen Harbiye and {de Taeye}, {Steven W.} and {van der Ham}, {Alwin J.} and {de Boer}, Leonie and Zaat, {Sebastiaan A. J.} and {van Weeghel}, Michel and Baeten, {Dominique L. P.} and Houtkooper, {Riekelt H.} and Bart Everts and Gestur Vidarsson and {den Dunnen}, Jeroen",
year = "2020",
month = dec,
day = "15",
doi = "10.4049/jimmunol.2000263",
language = "English",
volume = "205",
pages = "3400--3407",
journal = "Journal of immunology (Baltimore, Md.",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "12",

}

RIS

TY - JOUR

T1 - IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming

AU - Hoepel, Willianne

AU - Allahverdiyeva, Sona

AU - Harbiye, Haneen

AU - de Taeye, Steven W.

AU - van der Ham, Alwin J.

AU - de Boer, Leonie

AU - Zaat, Sebastiaan A. J.

AU - van Weeghel, Michel

AU - Baeten, Dominique L. P.

AU - Houtkooper, Riekelt H.

AU - Everts, Bart

AU - Vidarsson, Gestur

AU - den Dunnen, Jeroen

PY - 2020/12/15

Y1 - 2020/12/15

N2 - IgG Abs are crucial for various immune functions, including neutralization, phagocytosis, and Ab-dependent cellular cytotoxicity. In this study, we identified another function of IgG by showing that IgG immune complexes elicit distinct cytokine profiles by human myeloid immune cells, which are dependent on FcgR activation by the different IgG subclasses. Using monoclonal IgG subclasses with identical Ag specificity, our data demonstrate that the production of Th17-inducing cytokines, such as TNF, IL-1b, and IL-23, is particularly dependent on IgG2, whereas type I IFN responses are controlled by IgG3, and IgG1 is able to regulate both. In addition, we identified that subclass-specific cytokine production is orchestrated at the posttranscriptional level through distinct glycolytic reprogramming of human myeloid immune cells. Combined, these data identify that IgG subclasses provide pathogen- and cell type-specific immunity through differential metabolic reprogramming by FcgRs. These findings may be relevant for future design of Ab-related therapies in the context of infectious diseases, chronic inflammation, and cancer.

AB - IgG Abs are crucial for various immune functions, including neutralization, phagocytosis, and Ab-dependent cellular cytotoxicity. In this study, we identified another function of IgG by showing that IgG immune complexes elicit distinct cytokine profiles by human myeloid immune cells, which are dependent on FcgR activation by the different IgG subclasses. Using monoclonal IgG subclasses with identical Ag specificity, our data demonstrate that the production of Th17-inducing cytokines, such as TNF, IL-1b, and IL-23, is particularly dependent on IgG2, whereas type I IFN responses are controlled by IgG3, and IgG1 is able to regulate both. In addition, we identified that subclass-specific cytokine production is orchestrated at the posttranscriptional level through distinct glycolytic reprogramming of human myeloid immune cells. Combined, these data identify that IgG subclasses provide pathogen- and cell type-specific immunity through differential metabolic reprogramming by FcgRs. These findings may be relevant for future design of Ab-related therapies in the context of infectious diseases, chronic inflammation, and cancer.

UR - http://www.scopus.com/inward/record.url?scp=85097489013&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.2000263

DO - 10.4049/jimmunol.2000263

M3 - Article

C2 - 33188071

VL - 205

SP - 3400

EP - 3407

JO - Journal of immunology (Baltimore, Md.

JF - Journal of immunology (Baltimore, Md.

SN - 0022-1767

IS - 12

ER -

ID: 14166130