Research output: Contribution to journal › Article › Academic › peer-review
Higher spatial resolution improves the interpretation of the extent of ventricular trabeculation. / Riekerk, Hanne C. E.; Coolen, Bram F.; J. Strijkers, Gustav et al.
In: Journal of anatomy, Vol. 240, No. 2, 02.2022, p. 357-375.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Higher spatial resolution improves the interpretation of the extent of ventricular trabeculation
AU - Riekerk, Hanne C. E.
AU - Coolen, Bram F.
AU - J. Strijkers, Gustav
AU - van der Wal, Allard C.
AU - Petersen, Steffen E.
AU - Sheppard, Mary N.
AU - Oostra, Roelof-Jan
AU - Christoffels, Vincent M.
AU - Jensen, Bjarke
N1 - Funding Information: Megan Vos provided excellent assistance with histology. SEP acknowledges support from the National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Centre at Barts. VMC received funding from Netherlands Heart Foundation OUTREACH. Publisher Copyright: © 2021 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2022/2
Y1 - 2022/2
N2 - The ventricular walls of the human heart comprise an outer compact layer and an inner trabecular layer. In the context of an increased pre-test probability, diagnosis left ventricular noncompaction cardiomyopathy is given when the left ventricle is excessively trabeculated in volume (trabecular vol >25% of total LV wall volume) or thickness (trabecular/compact (T/C) >2.3). Here, we investigated whether higher spatial resolution affects the detection of trabeculation and thus the assessment of normal and excessively trabeculated wall morphology. First, we screened left ventricles in 1112 post-natal autopsy hearts. We identified five excessively trabeculated hearts and this low prevalence of excessive trabeculation is in agreement with pathology reports but contrasts the prevalence of approximately 10% of the population found by in vivo non-invasive imaging. Using macroscopy, histology and low- and high-resolution MRI, the five excessively trabeculated hearts were compared with six normal hearts and seven abnormally trabeculated and excessive trabeculation-negative hearts. Some abnormally trabeculated hearts could be considered excessively trabeculated macroscopically because of a trabecular outflow or an excessive number of trabeculations, but they were excessive trabeculation-negative when assessed with MRI-based measurements (T/C <2.3 and vol <25%). The number of detected trabeculations and T/C ratio were positively correlated with higher spatial resolution. Using measurements on high resolution MRI and with histological validation, we could not replicate the correlation between trabeculations of the left and right ventricle that has been previously reported. In conclusion, higher spatial resolution may affect the sensitivity of diagnostic measurements and in addition could allow for novel measurements such as counting of trabeculations.
AB - The ventricular walls of the human heart comprise an outer compact layer and an inner trabecular layer. In the context of an increased pre-test probability, diagnosis left ventricular noncompaction cardiomyopathy is given when the left ventricle is excessively trabeculated in volume (trabecular vol >25% of total LV wall volume) or thickness (trabecular/compact (T/C) >2.3). Here, we investigated whether higher spatial resolution affects the detection of trabeculation and thus the assessment of normal and excessively trabeculated wall morphology. First, we screened left ventricles in 1112 post-natal autopsy hearts. We identified five excessively trabeculated hearts and this low prevalence of excessive trabeculation is in agreement with pathology reports but contrasts the prevalence of approximately 10% of the population found by in vivo non-invasive imaging. Using macroscopy, histology and low- and high-resolution MRI, the five excessively trabeculated hearts were compared with six normal hearts and seven abnormally trabeculated and excessive trabeculation-negative hearts. Some abnormally trabeculated hearts could be considered excessively trabeculated macroscopically because of a trabecular outflow or an excessive number of trabeculations, but they were excessive trabeculation-negative when assessed with MRI-based measurements (T/C <2.3 and vol <25%). The number of detected trabeculations and T/C ratio were positively correlated with higher spatial resolution. Using measurements on high resolution MRI and with histological validation, we could not replicate the correlation between trabeculations of the left and right ventricle that has been previously reported. In conclusion, higher spatial resolution may affect the sensitivity of diagnostic measurements and in addition could allow for novel measurements such as counting of trabeculations.
KW - cardiomyopathy
KW - heart
KW - magnetic resonance imaging
KW - noncompaction
UR - http://www.scopus.com/inward/record.url?scp=85115692832&partnerID=8YFLogxK
U2 - 10.1111/joa.13559
DO - 10.1111/joa.13559
M3 - Article
C2 - 34569075
VL - 240
SP - 357
EP - 375
JO - Journal of anatomy
JF - Journal of anatomy
SN - 0021-8782
IS - 2
ER -
ID: 19885234