Research output: Contribution to journal › Article › Professional
Het belang van intramusculaire vitamine K-toediening bij pasgeborenen. / Berendse, Kevin; de Meij, Tim G. J.; Verheij, Joanne et al.
In: Nederlands tijdschrift voor geneeskunde, Vol. 165, No. 37, D5736, 26.07.2021.Research output: Contribution to journal › Article › Professional
}
TY - JOUR
T1 - Het belang van intramusculaire vitamine K-toediening bij pasgeborenen
AU - Berendse, Kevin
AU - de Meij, Tim G. J.
AU - Verheij, Joanne
AU - Nijmeijer, S. W. R.
AU - Heijboer, Harriët
AU - Geukers, Vincent G. M.
N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/7/26
Y1 - 2021/7/26
N2 - BACKGROUND: Infants who are born in The Netherlands receive oral vitamin K to prevent bleeding due to a vitamin K deficiency. However the incidence of such bleedings are higher compared to other European countries. Therefore, the Dutch Health Council advised in 2017 to change this guideline from oral to intramuscular administration. CASE DESCRIPTION: A 2 months old girl presented with a fatal intracranial hemorrhage. A day before she developed a hematoma on her foot and orbit. Despite daily oral vitamin K, blood results revealed a severe vitamin K deficiency-related bleeding. Postmortem liver biopsy and genetic studies showed cholestasis as the most likely cause of malabsorption of fat soluble vitamins due to a heterozygous pathogenic variant in the ABCB11 gene, which could possibly be transient. CONCLUSION: Our case illustrates the importance of revising the national guideline for vitamin K prophylaxis to intramuscular administration, according to the recommendation of the Dutch Health Council.
AB - BACKGROUND: Infants who are born in The Netherlands receive oral vitamin K to prevent bleeding due to a vitamin K deficiency. However the incidence of such bleedings are higher compared to other European countries. Therefore, the Dutch Health Council advised in 2017 to change this guideline from oral to intramuscular administration. CASE DESCRIPTION: A 2 months old girl presented with a fatal intracranial hemorrhage. A day before she developed a hematoma on her foot and orbit. Despite daily oral vitamin K, blood results revealed a severe vitamin K deficiency-related bleeding. Postmortem liver biopsy and genetic studies showed cholestasis as the most likely cause of malabsorption of fat soluble vitamins due to a heterozygous pathogenic variant in the ABCB11 gene, which could possibly be transient. CONCLUSION: Our case illustrates the importance of revising the national guideline for vitamin K prophylaxis to intramuscular administration, according to the recommendation of the Dutch Health Council.
UR - http://www.scopus.com/inward/record.url?scp=85113465393&partnerID=8YFLogxK
M3 - Article
C2 - 34346618
VL - 165
JO - Nederlands tijdschrift voor geneeskunde
JF - Nederlands tijdschrift voor geneeskunde
SN - 0028-2162
IS - 37
M1 - D5736
ER -
ID: 19512368