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Hemodynamic Study of a Patient-Specific Intracranial Aneurysm : Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics. / Wu, Xiaolin; Gürzing, Stefanie; Schinkel, Christiaan et al.

In: Cardiovascular engineering and technology, 2021.

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Wu X, Gürzing S, Schinkel C, Toussaint M, Perinajová R, van Ooij P et al. Hemodynamic Study of a Patient-Specific Intracranial Aneurysm: Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics. Cardiovascular engineering and technology. 2021. Epub 2021. doi: 10.1007/s13239-021-00583-2

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Wu, Xiaolin ; Gürzing, Stefanie ; Schinkel, Christiaan et al. / Hemodynamic Study of a Patient-Specific Intracranial Aneurysm : Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics. In: Cardiovascular engineering and technology. 2021.

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@article{7913a7e76d2e4033a76560db82d0c2b5,
title = "Hemodynamic Study of a Patient-Specific Intracranial Aneurysm: Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics",
abstract = "Introduction: Wall shear stress (WSS) is associated with the growth and rupture of an intracranial aneurysm. To reveal their underlying connections, many image-based computational fluid dynamics (CFD) studies have been conducted. However, the methodological validations using both in vivo medical imaging and in vitro optical flow measurements were rarely accompanied in such studies. Methods: In the present study, we performed a comparative assessment on the hemodynamics of a patient-specific intracranial saccular aneurysm using in vivo 4D Flow MRI, in silico CFD, in vitro stereoscopic and tomographic particle imaging velocimetry (Stereo-PIV and Tomo-PIV) techniques. PIV experiments and CFD were conducted under steady state corresponding to the peak systole of 4D Flow MRI. Results: The results showed that all modalities provided similar flow features and overall surface distribution of WSS. However, a large variation in the absolute WSS values was found. 4D Flow MRI estimated a 2- to 4-fold lower peak WSS (3.99 Pa) and a 1.6- to 2-fold lower mean WSS (0.94 Pa) than Tomo-PIV, Stereo-PIV, and CFD. Bland-Altman plots of WSS showed that the differences between PIV-/CFD-based WSS and 4D Flow MRI-based WSS increase with higher WSS magnitude. Such proportional trend was absent in the Bland-Altman comparison of velocity where the resolutions of PIV and CFD datasets were matched to 4D Flow MRI. We also found that because of superior resolution in the out-of-plane direction, WSS estimation by Tomo-PIV was higher than Stereo-PIV. Conclusions: Our results indicated that the differences in spatial resolution could be the main contributor to the discrepancies between each modality. The findings of this study suggest that with current techniques, care should be taken when using absolute WSS values to perform a quantitative risk analysis of aneurysm rupture.",
keywords = "4D Flow MRI, Computational fluid dynamics, Hemodynamics, Intracranial aneurysm, Particle image velocimetry, Wall shear stress",
author = "Xiaolin Wu and Stefanie G{\"u}rzing and Christiaan Schinkel and Merel Toussaint and Romana Perinajov{\'a} and {van Ooij}, Pim and Sa{\v s}a Kenjere{\v s}",
note = "Funding Information: The research of Xiaolin Wu was made possible by the financial support of the Chinese Scholarship Council (CSC). Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
doi = "10.1007/s13239-021-00583-2",
language = "English",
journal = "Cardiovascular engineering and technology",
issn = "1869-408X",
publisher = "Springer Publishing Company",

}

RIS

TY - JOUR

T1 - Hemodynamic Study of a Patient-Specific Intracranial Aneurysm

T2 - Comparative Assessment of Tomographic PIV, Stereoscopic PIV, In Vivo MRI and Computational Fluid Dynamics

AU - Wu, Xiaolin

AU - Gürzing, Stefanie

AU - Schinkel, Christiaan

AU - Toussaint, Merel

AU - Perinajová, Romana

AU - van Ooij, Pim

AU - Kenjereš, Saša

N1 - Funding Information: The research of Xiaolin Wu was made possible by the financial support of the Chinese Scholarship Council (CSC). Publisher Copyright: © 2021, The Author(s).

PY - 2021

Y1 - 2021

N2 - Introduction: Wall shear stress (WSS) is associated with the growth and rupture of an intracranial aneurysm. To reveal their underlying connections, many image-based computational fluid dynamics (CFD) studies have been conducted. However, the methodological validations using both in vivo medical imaging and in vitro optical flow measurements were rarely accompanied in such studies. Methods: In the present study, we performed a comparative assessment on the hemodynamics of a patient-specific intracranial saccular aneurysm using in vivo 4D Flow MRI, in silico CFD, in vitro stereoscopic and tomographic particle imaging velocimetry (Stereo-PIV and Tomo-PIV) techniques. PIV experiments and CFD were conducted under steady state corresponding to the peak systole of 4D Flow MRI. Results: The results showed that all modalities provided similar flow features and overall surface distribution of WSS. However, a large variation in the absolute WSS values was found. 4D Flow MRI estimated a 2- to 4-fold lower peak WSS (3.99 Pa) and a 1.6- to 2-fold lower mean WSS (0.94 Pa) than Tomo-PIV, Stereo-PIV, and CFD. Bland-Altman plots of WSS showed that the differences between PIV-/CFD-based WSS and 4D Flow MRI-based WSS increase with higher WSS magnitude. Such proportional trend was absent in the Bland-Altman comparison of velocity where the resolutions of PIV and CFD datasets were matched to 4D Flow MRI. We also found that because of superior resolution in the out-of-plane direction, WSS estimation by Tomo-PIV was higher than Stereo-PIV. Conclusions: Our results indicated that the differences in spatial resolution could be the main contributor to the discrepancies between each modality. The findings of this study suggest that with current techniques, care should be taken when using absolute WSS values to perform a quantitative risk analysis of aneurysm rupture.

AB - Introduction: Wall shear stress (WSS) is associated with the growth and rupture of an intracranial aneurysm. To reveal their underlying connections, many image-based computational fluid dynamics (CFD) studies have been conducted. However, the methodological validations using both in vivo medical imaging and in vitro optical flow measurements were rarely accompanied in such studies. Methods: In the present study, we performed a comparative assessment on the hemodynamics of a patient-specific intracranial saccular aneurysm using in vivo 4D Flow MRI, in silico CFD, in vitro stereoscopic and tomographic particle imaging velocimetry (Stereo-PIV and Tomo-PIV) techniques. PIV experiments and CFD were conducted under steady state corresponding to the peak systole of 4D Flow MRI. Results: The results showed that all modalities provided similar flow features and overall surface distribution of WSS. However, a large variation in the absolute WSS values was found. 4D Flow MRI estimated a 2- to 4-fold lower peak WSS (3.99 Pa) and a 1.6- to 2-fold lower mean WSS (0.94 Pa) than Tomo-PIV, Stereo-PIV, and CFD. Bland-Altman plots of WSS showed that the differences between PIV-/CFD-based WSS and 4D Flow MRI-based WSS increase with higher WSS magnitude. Such proportional trend was absent in the Bland-Altman comparison of velocity where the resolutions of PIV and CFD datasets were matched to 4D Flow MRI. We also found that because of superior resolution in the out-of-plane direction, WSS estimation by Tomo-PIV was higher than Stereo-PIV. Conclusions: Our results indicated that the differences in spatial resolution could be the main contributor to the discrepancies between each modality. The findings of this study suggest that with current techniques, care should be taken when using absolute WSS values to perform a quantitative risk analysis of aneurysm rupture.

KW - 4D Flow MRI

KW - Computational fluid dynamics

KW - Hemodynamics

KW - Intracranial aneurysm

KW - Particle image velocimetry

KW - Wall shear stress

UR - http://www.scopus.com/inward/record.url?scp=85118673011&partnerID=8YFLogxK

U2 - 10.1007/s13239-021-00583-2

DO - 10.1007/s13239-021-00583-2

M3 - Article

C2 - 34750782

JO - Cardiovascular engineering and technology

JF - Cardiovascular engineering and technology

SN - 1869-408X

ER -

ID: 20390182