Standard

Health care utilization and outcomes in older adults after Traumatic Brain Injury : A CENTER-TBI study. / van der Vlegel, Marjolein; Mikolić, Ana; Lee Hee, Quentin et al.

In: Injury, Vol. 53, No. 8, 08.2022, p. 2774-2782.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

van der Vlegel, M, Mikolić, A, Lee Hee, Q, Kaplan, ZLR, Retel Helmrich, IRA, van Veen, E, Andelic, N, Steinbuechel, NV, Plass, AM, Zeldovich, M, Wilson, L, Maas, AIR, Haagsma, JA, Polinder, S, Åkerlund, C, George, P, Lanyon, L, Muraleedharan, V, Nelson, D, Amrein, K, Ezer, E, Kovács, N, Melegh, BL, Nyirádi, JZ, Tamás, V, Vámos, Z, Sorinola, A, Andreassen, L, Anke, A, Frisvold, S, Antoni, A, Schwendenwein, E, Audibert, GR, Azouvi, P, Azzolini, ML, Beretta, L, Calvi, MR, Bartels, R, Boogert, HD, Barzó, PL, Beauvais, R, Perera, N, Beer, R, Helbok, R, Bellander, B-M, Belli, A, Benali, H, Degos, V, Galanaud, D, Perlbarg, V, Berardino, M, Cavallo, S, Blaabjerg, M, Rosenlund, C, Schou, RF, Bragge, P, Brazinova, A, Majdan, M, Taylor, MS, Zelinkova, V, Brinck, V, Jarrett, M, Brooker, J, Donoghue, E, Synnot, A, Brorsson, C, Koskinen, L-O, Sundström, N, Buki, A, Czeiter, E, Bullinger, M, Cabeleira, M, Czosnyka, M, Dixit, A, Ercole, A, Koraropoulos, E, Menon, D, Newcombe, V, Richter, S, Smielewski, P, Stamatakis, E, Williams, G, Winzeck, S, Zeiler, FA, Caccioppola, A, Calappi, E, Carbonara, M, Ortolano, F, Zoerle, T, Stocchetti, N, Cameron, P, Gantner, D, Murray, L, Trapani, T, Vallance, S, Lozano, GC, Pomposo, I, Castaño-León, AM, Gomez, PA, Lagares, A, Chevallard, G, Chieregato, A, Citerio, G, Vargiolu, A, Ceyisakar, I, Gravesteijn, B, Huijben, J, Lingsma, H, Nieboer, D, Mikolic, A, Sewalt, C, Steyerberg, EW, Velt, K, Voormolen, D, Wiegers, E, Peul, W, van Dijck, JTJM, van Essen, TA, van Wijk, RPJ, Clusmann, H, Coburn, M, Kowark, A, Rossaint, R, Coles, J, Cooper, JD, Correia, M, Čovid, A, von Steinbüchel, N, Curry, N, Stanworth, S, Dahyot-Fizelier, C, Dark, P, Johnson, F, Dawes, H, Esser, P, van Heugten, C, de Keyser, VR, Menovsky, T, van der Steen, G, Corte, FD, Grossi, F, Depreitere, B, Đilvesi, Đ, Golubovic, J, Karan, M, Vulekovic, P, Dreier, J, Vajkoczy, P, Wolf, S, Dulière, G-L, Maréchal, H, Fabricius, M, Kondziella, D, Feigin, VL, Jones, K, Ao, BT, Theadom, A, Foks, K, Haitsma, I, Volovici, V, Furmanov, A, Rosenthal, G, Gagliardo, P, Gao, G, Jiang, J, Ghuysen, A, Giga, L, Valeinis, E, Ziverte, A, Glocker, B, Rueckert, D, Gratz, J, Gruen, RL, Gupta, D, Roe, C, Helseth, E, Roise, O, Horton, L, Hutchinson, PJ, Kolias, AG, Jacobs, B, van der Naalt, J, Jankowski, S, Kompanje, E, Timmers, M, Laureys, S, Ledoux, D, Misset, B, Lecky, F, Olubukola, O, Lefering, R, Schäfer, N, Legrand, V, Lejeune, A, Vega, E, Mattern, J, Levi, L, Lightfoot, R, Maegele, M, Manara, A, Thomas, M, Manley, G, Martino, C, Sakowitz, O, Sanchez-Porras, R, Younsi, A, McMahon, C, Negru, A, Oresic, M, Palotie, A, Parizel, PM, Payen, J-F, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Posti, JP, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rhodes, J, Richardson, S, Ripatti, S, Rocka, S, Rosand, J, Rosenfeld, JV, Rossi, S, Rusnák, M, Sahuquillo, J, Sandor, J, Schmidt, S, Schoechl, H, Schoonman, G, Skandsen, T, Stevens, R, Stewart, W, Takala, R, Tamosuitis, T, Tenovuo, O, Tibboel, D, Tolias, C, Tudora, CM, van der Jagt, M, van Hecke, W, van Praag, D, Vyvere, TV, Verheyden, J, Vespa, PM, Vik, A, Vilcinis, R, Wang, KKW, Yang, Z & Ylén, P 2022, 'Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study', Injury, vol. 53, no. 8, pp. 2774-2782. https://doi.org/10.1016/j.injury.2022.05.009

APA

van der Vlegel, M., Mikolić, A., Lee Hee, Q., Kaplan, Z. L. R., Retel Helmrich, I. R. A., van Veen, E., Andelic, N., Steinbuechel, N. V., Plass, A. M., Zeldovich, M., Wilson, L., Maas, A. I. R., Haagsma, J. A., Polinder, S., Åkerlund, C., George, P., Lanyon, L., Muraleedharan, V., Nelson, D., ... Ylén, P. (2022). Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study. Injury, 53(8), 2774-2782. https://doi.org/10.1016/j.injury.2022.05.009

Vancouver

van der Vlegel M, Mikolić A, Lee Hee Q, Kaplan ZLR, Retel Helmrich IRA, van Veen E et al. Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study. Injury. 2022 Aug;53(8):2774-2782. Epub 2022. doi: 10.1016/j.injury.2022.05.009

Author

van der Vlegel, Marjolein ; Mikolić, Ana ; Lee Hee, Quentin et al. / Health care utilization and outcomes in older adults after Traumatic Brain Injury : A CENTER-TBI study. In: Injury. 2022 ; Vol. 53, No. 8. pp. 2774-2782.

BibTeX

@article{0d41a7aee51449c4b03a33e4c8a1163e,
title = "Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study",
abstract = "Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.",
keywords = "Health care utilization, Health-related quality of life, Mental health, Older adults, Outcomes, Traumatic Brain Injury",
author = "{van der Vlegel}, Marjolein and Ana Mikoli{\'c} and {Lee Hee}, Quentin and Kaplan, {Z. L. Rana} and {Retel Helmrich}, {Isabel R. A.} and {van Veen}, Ernest and Nada Andelic and Steinbuechel, {Nicole v.} and Plass, {Anne Marie} and Marina Zeldovich and Lindsay Wilson and Maas, {Andrew I. R.} and Haagsma, {Juanita A.} and Suzanne Polinder and Cecilia {\AA}kerlund and Pradeep George and Linda Lanyon and Visakh Muraleedharan and David Nelson and Krisztina Amrein and Erzs{\'e}bet Ezer and No{\'e}mi Kov{\'a}cs and Melegh, {B. la} and Nyir{\'a}di, {J. zsef} and Vikt{\'o}ria Tam{\'a}s and Zolt{\'a}n V{\'a}mos and Abayomi Sorinola and Lasse Andreassen and Audny Anke and Shirin Frisvold and Anna Antoni and Elisabeth Schwendenwein and Audibert, {G. rard} and Philippe Azouvi and Azzolini, {Maria Luisa} and Luigi Beretta and Calvi, {Maria Rosa} and Ronald Bartels and Boogert, {Hugo den} and Barz{\'o}, {P. l} and Romuald Beauvais and Natascha Perera and Ronny Beer and Raimund Helbok and Bo-Michael Bellander and Antonio Belli and Habib Benali and Vincent Degos and Damien Galanaud and Vincent Perlbarg and Maurizio Berardino and Simona Cavallo and Morten Blaabjerg and Christina Rosenlund and Schou, {Rico Frederik} and Peter Bragge and Alexandra Brazinova and Marek Majdan and Taylor, {Mark Steven} and Veronika Zelinkova and Vibeke Brinck and Mike Jarrett and Joanne Brooker and Emma Donoghue and Anneliese Synnot and Camilla Brorsson and Lars-Owe Koskinen and Nina Sundstr{\"o}m and Andras Buki and Endre Czeiter and Monika Bullinger and Manuel Cabeleira and Marek Czosnyka and Abhishek Dixit and Ari Ercole and Evgenios Koraropoulos and David Menon and Virginia Newcombe and Sophie Richter and Peter Smielewski and Emmanuel Stamatakis and Guy Williams and Stefan Winzeck and Zeiler, {Frederick A.} and Alessio Caccioppola and Emiliana Calappi and Marco Carbonara and Fabrizio Ortolano and Tommaso Zoerle and Nino Stocchetti and Peter Cameron and Dashiell Gantner and Lynnette Murray and Tony Trapani and Shirley Vallance and Lozano, {Guillermo Carbayo} and Inigo Pomposo and Casta{\~n}o-Le{\'o}n, {Ana M.} and Gomez, {Pedro A.} and Alfonso Lagares and Giorgio Chevallard and Arturo Chieregato and Giuseppe Citerio and Alessia Vargiolu and Iris Ceyisakar and Benjamin Gravesteijn and Jilske Huijben and Hester Lingsma and Daan Nieboer and Ana Mikolic and Charlie Sewalt and Steyerberg, {Ewout W.} and Kimberley Velt and Daphne Voormolen and Eveline Wiegers and Wilco Peul and {van Dijck}, {Jeroen T. J. M.} and {van Essen}, {Thomas A.} and {van Wijk}, {Roel P. J.} and Hans Clusmann and Mark Coburn and Ana Kowark and Rolf Rossaint and Jonathan Coles and Cooper, {Jamie D.} and Marta Correia and Amra {\v C}ovid and {von Steinb{\"u}chel}, Nicole and Nicola Curry and Simon Stanworth and Claire Dahyot-Fizelier and Paul Dark and Faye Johnson and Helen Dawes and Patrick Esser and {van Heugten}, Caroline and {de Keyser}, {V. ronique} and Tomas Menovsky and {van der Steen}, Gregory and Corte, {Francesco Della} and Francesca Grossi and Bart Depreitere and {\D}ula {\D}ilvesi and Jago{\v s} Golubovic and Mladen Karan and Petar Vulekovic and Jens Dreier and Peter Vajkoczy and Stefan Wolf and Guy-Loup Duli{\`e}re and Hugues Mar{\'e}chal and Martin Fabricius and Daniel Kondziella and Feigin, {Valery L.} and Kelly Jones and Ao, {Braden Te} and Alice Theadom and Kelly Foks and Iain Haitsma and Victor Volovici and Alex Furmanov and Guy Rosenthal and Pablo Gagliardo and Guoyi Gao and Ji-yao Jiang and Alexandre Ghuysen and Lelde Giga and Egils Valeinis and Agate Ziverte and Ben Glocker and Daniel Rueckert and Johannes Gratz and Gruen, {Russell L.} and Deepak Gupta and Cecilie Roe and Eirik Helseth and Olav Roise and Lindsay Horton and Hutchinson, {Peter J.} and Kolias, {Angelos G.} and Bram Jacobs and {van der Naalt}, Joukje and Stefan Jankowski and Erwin Kompanje and Marjolein Timmers and Steven Laureys and Didier Ledoux and Benoit Misset and Fiona Lecky and Otesile Olubukola and Rolf Lefering and Nadine Sch{\"a}fer and Valerie Legrand and Aurelie Lejeune and Emmanuel Vega and Julia Mattern and Leon Levi and Roger Lightfoot and Marc Maegele and Alex Manara and Matt Thomas and Geoffrey Manley and Costanza Martino and Oliver Sakowitz and Renan Sanchez-Porras and Alexander Younsi and Catherine McMahon and Ancuta Negru and Matej Oresic and Aarno Palotie and Parizel, {Paul M.} and Jean-Fran{\c c}ois Payen and Paolo Persona and Anna Piippo-Karjalainen and Matti Pirinen and Horia Ples and Posti, {Jussi P.} and Louis Puybasset and Andreea Radoi and Arminas Ragauskas and Rahul Raj and Malinka Rambadagalla and Jonathan Rhodes and Sylvia Richardson and Samuli Ripatti and Saulius Rocka and Jonathan Rosand and Rosenfeld, {Jeffrey V.} and Sandra Rossi and Martin Rusn{\'a}k and Juan Sahuquillo and Janos Sandor and Silke Schmidt and Herbert Schoechl and Guus Schoonman and Toril Skandsen and Robert Stevens and William Stewart and Riikka Takala and Tomas Tamosuitis and Olli Tenovuo and Dick Tibboel and Christos Tolias and Tudora, {Cristina Maria} and {van der Jagt}, Mathieu and {van Hecke}, Wim and {van Praag}, Dominique and Vyvere, {Thijs Vande} and Jan Verheyden and Vespa, {Paul M.} and Anne Vik and Rimantas Vilcinis and Wang, {Kevin K. W.} and Zhihui Yang and Peter Yl{\'e}n",
note = "Funding Information: CENTER-TBI was supported by the European Union 7th Framework program (EC Grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA). Funding Information: CENTER-TBI was supported by the European Union 7th Framework program ( EC Grant 602150 ). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA) . Publisher Copyright: {\textcopyright} 2022",
year = "2022",
month = aug,
doi = "10.1016/j.injury.2022.05.009",
language = "English",
volume = "53",
pages = "2774--2782",
journal = "Injury",
issn = "0020-1383",
publisher = "Elsevier Limited",
number = "8",

}

RIS

TY - JOUR

T1 - Health care utilization and outcomes in older adults after Traumatic Brain Injury

T2 - A CENTER-TBI study

AU - van der Vlegel, Marjolein

AU - Mikolić, Ana

AU - Lee Hee, Quentin

AU - Kaplan, Z. L. Rana

AU - Retel Helmrich, Isabel R. A.

AU - van Veen, Ernest

AU - Andelic, Nada

AU - Steinbuechel, Nicole v.

AU - Plass, Anne Marie

AU - Zeldovich, Marina

AU - Wilson, Lindsay

AU - Maas, Andrew I. R.

AU - Haagsma, Juanita A.

AU - Polinder, Suzanne

AU - Åkerlund, Cecilia

AU - George, Pradeep

AU - Lanyon, Linda

AU - Muraleedharan, Visakh

AU - Nelson, David

AU - Amrein, Krisztina

AU - Ezer, Erzsébet

AU - Kovács, Noémi

AU - Melegh, B. la

AU - Nyirádi, J. zsef

AU - Tamás, Viktória

AU - Vámos, Zoltán

AU - Sorinola, Abayomi

AU - Andreassen, Lasse

AU - Anke, Audny

AU - Frisvold, Shirin

AU - Antoni, Anna

AU - Schwendenwein, Elisabeth

AU - Audibert, G. rard

AU - Azouvi, Philippe

AU - Azzolini, Maria Luisa

AU - Beretta, Luigi

AU - Calvi, Maria Rosa

AU - Bartels, Ronald

AU - Boogert, Hugo den

AU - Barzó, P. l

AU - Beauvais, Romuald

AU - Perera, Natascha

AU - Beer, Ronny

AU - Helbok, Raimund

AU - Bellander, Bo-Michael

AU - Belli, Antonio

AU - Benali, Habib

AU - Degos, Vincent

AU - Galanaud, Damien

AU - Perlbarg, Vincent

AU - Berardino, Maurizio

AU - Cavallo, Simona

AU - Blaabjerg, Morten

AU - Rosenlund, Christina

AU - Schou, Rico Frederik

AU - Bragge, Peter

AU - Brazinova, Alexandra

AU - Majdan, Marek

AU - Taylor, Mark Steven

AU - Zelinkova, Veronika

AU - Brinck, Vibeke

AU - Jarrett, Mike

AU - Brooker, Joanne

AU - Donoghue, Emma

AU - Synnot, Anneliese

AU - Brorsson, Camilla

AU - Koskinen, Lars-Owe

AU - Sundström, Nina

AU - Buki, Andras

AU - Czeiter, Endre

AU - Bullinger, Monika

AU - Cabeleira, Manuel

AU - Czosnyka, Marek

AU - Dixit, Abhishek

AU - Ercole, Ari

AU - Koraropoulos, Evgenios

AU - Menon, David

AU - Newcombe, Virginia

AU - Richter, Sophie

AU - Smielewski, Peter

AU - Stamatakis, Emmanuel

AU - Williams, Guy

AU - Winzeck, Stefan

AU - Zeiler, Frederick A.

AU - Caccioppola, Alessio

AU - Calappi, Emiliana

AU - Carbonara, Marco

AU - Ortolano, Fabrizio

AU - Zoerle, Tommaso

AU - Stocchetti, Nino

AU - Cameron, Peter

AU - Gantner, Dashiell

AU - Murray, Lynnette

AU - Trapani, Tony

AU - Vallance, Shirley

AU - Lozano, Guillermo Carbayo

AU - Pomposo, Inigo

AU - Castaño-León, Ana M.

AU - Gomez, Pedro A.

AU - Lagares, Alfonso

AU - Chevallard, Giorgio

AU - Chieregato, Arturo

AU - Citerio, Giuseppe

AU - Vargiolu, Alessia

AU - Ceyisakar, Iris

AU - Gravesteijn, Benjamin

AU - Huijben, Jilske

AU - Lingsma, Hester

AU - Nieboer, Daan

AU - Mikolic, Ana

AU - Sewalt, Charlie

AU - Steyerberg, Ewout W.

AU - Velt, Kimberley

AU - Voormolen, Daphne

AU - Wiegers, Eveline

AU - Peul, Wilco

AU - van Dijck, Jeroen T. J. M.

AU - van Essen, Thomas A.

AU - van Wijk, Roel P. J.

AU - Clusmann, Hans

AU - Coburn, Mark

AU - Kowark, Ana

AU - Rossaint, Rolf

AU - Coles, Jonathan

AU - Cooper, Jamie D.

AU - Correia, Marta

AU - Čovid, Amra

AU - von Steinbüchel, Nicole

AU - Curry, Nicola

AU - Stanworth, Simon

AU - Dahyot-Fizelier, Claire

AU - Dark, Paul

AU - Johnson, Faye

AU - Dawes, Helen

AU - Esser, Patrick

AU - van Heugten, Caroline

AU - de Keyser, V. ronique

AU - Menovsky, Tomas

AU - van der Steen, Gregory

AU - Corte, Francesco Della

AU - Grossi, Francesca

AU - Depreitere, Bart

AU - Đilvesi, Đula

AU - Golubovic, Jagoš

AU - Karan, Mladen

AU - Vulekovic, Petar

AU - Dreier, Jens

AU - Vajkoczy, Peter

AU - Wolf, Stefan

AU - Dulière, Guy-Loup

AU - Maréchal, Hugues

AU - Fabricius, Martin

AU - Kondziella, Daniel

AU - Feigin, Valery L.

AU - Jones, Kelly

AU - Ao, Braden Te

AU - Theadom, Alice

AU - Foks, Kelly

AU - Haitsma, Iain

AU - Volovici, Victor

AU - Furmanov, Alex

AU - Rosenthal, Guy

AU - Gagliardo, Pablo

AU - Gao, Guoyi

AU - Jiang, Ji-yao

AU - Ghuysen, Alexandre

AU - Giga, Lelde

AU - Valeinis, Egils

AU - Ziverte, Agate

AU - Glocker, Ben

AU - Rueckert, Daniel

AU - Gratz, Johannes

AU - Gruen, Russell L.

AU - Gupta, Deepak

AU - Roe, Cecilie

AU - Helseth, Eirik

AU - Roise, Olav

AU - Horton, Lindsay

AU - Hutchinson, Peter J.

AU - Kolias, Angelos G.

AU - Jacobs, Bram

AU - van der Naalt, Joukje

AU - Jankowski, Stefan

AU - Kompanje, Erwin

AU - Timmers, Marjolein

AU - Laureys, Steven

AU - Ledoux, Didier

AU - Misset, Benoit

AU - Lecky, Fiona

AU - Olubukola, Otesile

AU - Lefering, Rolf

AU - Schäfer, Nadine

AU - Legrand, Valerie

AU - Lejeune, Aurelie

AU - Vega, Emmanuel

AU - Mattern, Julia

AU - Levi, Leon

AU - Lightfoot, Roger

AU - Maegele, Marc

AU - Manara, Alex

AU - Thomas, Matt

AU - Manley, Geoffrey

AU - Martino, Costanza

AU - Sakowitz, Oliver

AU - Sanchez-Porras, Renan

AU - Younsi, Alexander

AU - McMahon, Catherine

AU - Negru, Ancuta

AU - Oresic, Matej

AU - Palotie, Aarno

AU - Parizel, Paul M.

AU - Payen, Jean-François

AU - Persona, Paolo

AU - Piippo-Karjalainen, Anna

AU - Pirinen, Matti

AU - Ples, Horia

AU - Posti, Jussi P.

AU - Puybasset, Louis

AU - Radoi, Andreea

AU - Ragauskas, Arminas

AU - Raj, Rahul

AU - Rambadagalla, Malinka

AU - Rhodes, Jonathan

AU - Richardson, Sylvia

AU - Ripatti, Samuli

AU - Rocka, Saulius

AU - Rosand, Jonathan

AU - Rosenfeld, Jeffrey V.

AU - Rossi, Sandra

AU - Rusnák, Martin

AU - Sahuquillo, Juan

AU - Sandor, Janos

AU - Schmidt, Silke

AU - Schoechl, Herbert

AU - Schoonman, Guus

AU - Skandsen, Toril

AU - Stevens, Robert

AU - Stewart, William

AU - Takala, Riikka

AU - Tamosuitis, Tomas

AU - Tenovuo, Olli

AU - Tibboel, Dick

AU - Tolias, Christos

AU - Tudora, Cristina Maria

AU - van der Jagt, Mathieu

AU - van Hecke, Wim

AU - van Praag, Dominique

AU - Vyvere, Thijs Vande

AU - Verheyden, Jan

AU - Vespa, Paul M.

AU - Vik, Anne

AU - Vilcinis, Rimantas

AU - Wang, Kevin K. W.

AU - Yang, Zhihui

AU - Ylén, Peter

N1 - Funding Information: CENTER-TBI was supported by the European Union 7th Framework program (EC Grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA). Funding Information: CENTER-TBI was supported by the European Union 7th Framework program ( EC Grant 602150 ). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA) . Publisher Copyright: © 2022

PY - 2022/8

Y1 - 2022/8

N2 - Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.

AB - Introduction: The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI. Methods: We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury. Results: Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms. Conclusion: The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive.

KW - Health care utilization

KW - Health-related quality of life

KW - Mental health

KW - Older adults

KW - Outcomes

KW - Traumatic Brain Injury

UR - http://www.scopus.com/inward/record.url?scp=85132842261&partnerID=8YFLogxK

U2 - 10.1016/j.injury.2022.05.009

DO - 10.1016/j.injury.2022.05.009

M3 - Article

C2 - 35725508

VL - 53

SP - 2774

EP - 2782

JO - Injury

JF - Injury

SN - 0020-1383

IS - 8

ER -

ID: 24608109