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Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. / Datema, Mareen R.; Zuidmeer-Jongejan, Laurian; Asero, Riccardo; Barreales, Laura; Belohlavkova, Simona; de Blay, Frédéric; Bures, Peter; Clausen, Michael; Dubakiene, Ruta; Gislason, David; Jedrzejczak-Czechowicz, Monika; Kowalski, Marek L.; Knulst, André C.; Kralimarkova, Tanya; Le, Thuy-My; Lovegrove, Alison; Marsh, Justin; Papadopoulos, Nikolaos G.; Popov, Todor; del Prado, Náyade; Purohit, Ashok; Reese, Gerald; Reig, Isabel; Seneviratne, Suranjith L.; Sinaniotis, Athanasios; Versteeg, Serge A.; Vieths, Stefan; Zwinderman, Aeilko H.; Mills, Clare; Lidholm, Jonas; Hoffmann-Sommergruber, Karin; Fernández-Rivas, Montserrat; Ballmer-Weber, Barbara; van Ree, Ronald.

In: Journal of allergy and clinical immunology, Vol. 136, No. 2, 2015, p. 382-391.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Datema, MR, Zuidmeer-Jongejan, L, Asero, R, Barreales, L, Belohlavkova, S, de Blay, F, Bures, P, Clausen, M, Dubakiene, R, Gislason, D, Jedrzejczak-Czechowicz, M, Kowalski, ML, Knulst, AC, Kralimarkova, T, Le, T-M, Lovegrove, A, Marsh, J, Papadopoulos, NG, Popov, T, del Prado, N, Purohit, A, Reese, G, Reig, I, Seneviratne, SL, Sinaniotis, A, Versteeg, SA, Vieths, S, Zwinderman, AH, Mills, C, Lidholm, J, Hoffmann-Sommergruber, K, Fernández-Rivas, M, Ballmer-Weber, B & van Ree, R 2015, 'Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey', Journal of allergy and clinical immunology, vol. 136, no. 2, pp. 382-391. https://doi.org/10.1016/j.jaci.2014.12.1949

APA

Datema, M. R., Zuidmeer-Jongejan, L., Asero, R., Barreales, L., Belohlavkova, S., de Blay, F., ... van Ree, R. (2015). Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. Journal of allergy and clinical immunology, 136(2), 382-391. https://doi.org/10.1016/j.jaci.2014.12.1949

Vancouver

Datema MR, Zuidmeer-Jongejan L, Asero R, Barreales L, Belohlavkova S, de Blay F et al. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. Journal of allergy and clinical immunology. 2015;136(2):382-391. https://doi.org/10.1016/j.jaci.2014.12.1949

Author

Datema, Mareen R. ; Zuidmeer-Jongejan, Laurian ; Asero, Riccardo ; Barreales, Laura ; Belohlavkova, Simona ; de Blay, Frédéric ; Bures, Peter ; Clausen, Michael ; Dubakiene, Ruta ; Gislason, David ; Jedrzejczak-Czechowicz, Monika ; Kowalski, Marek L. ; Knulst, André C. ; Kralimarkova, Tanya ; Le, Thuy-My ; Lovegrove, Alison ; Marsh, Justin ; Papadopoulos, Nikolaos G. ; Popov, Todor ; del Prado, Náyade ; Purohit, Ashok ; Reese, Gerald ; Reig, Isabel ; Seneviratne, Suranjith L. ; Sinaniotis, Athanasios ; Versteeg, Serge A. ; Vieths, Stefan ; Zwinderman, Aeilko H. ; Mills, Clare ; Lidholm, Jonas ; Hoffmann-Sommergruber, Karin ; Fernández-Rivas, Montserrat ; Ballmer-Weber, Barbara ; van Ree, Ronald. / Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. In: Journal of allergy and clinical immunology. 2015 ; Vol. 136, No. 2. pp. 382-391.

BibTeX

@article{e214bad639f24f02a08b9c9be583ed94,
title = "Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey",
abstract = "Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens. Establishing a molecular map of hazelnut allergy across Europe. In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP. Hazelnut allergy was confirmed in 70{\%} of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10{\%}, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10{\%} to 25{\%}), correlated with IgE to nuts, seeds, and pollen. In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established",
author = "Datema, {Mareen R.} and Laurian Zuidmeer-Jongejan and Riccardo Asero and Laura Barreales and Simona Belohlavkova and {de Blay}, Fr{\'e}d{\'e}ric and Peter Bures and Michael Clausen and Ruta Dubakiene and David Gislason and Monika Jedrzejczak-Czechowicz and Kowalski, {Marek L.} and Knulst, {Andr{\'e} C.} and Tanya Kralimarkova and Thuy-My Le and Alison Lovegrove and Justin Marsh and Papadopoulos, {Nikolaos G.} and Todor Popov and {del Prado}, N{\'a}yade and Ashok Purohit and Gerald Reese and Isabel Reig and Seneviratne, {Suranjith L.} and Athanasios Sinaniotis and Versteeg, {Serge A.} and Stefan Vieths and Zwinderman, {Aeilko H.} and Clare Mills and Jonas Lidholm and Karin Hoffmann-Sommergruber and Montserrat Fern{\'a}ndez-Rivas and Barbara Ballmer-Weber and {van Ree}, Ronald",
year = "2015",
doi = "10.1016/j.jaci.2014.12.1949",
language = "English",
volume = "136",
pages = "382--391",
journal = "Journal of allergy and clinical immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

AU - Datema, Mareen R.

AU - Zuidmeer-Jongejan, Laurian

AU - Asero, Riccardo

AU - Barreales, Laura

AU - Belohlavkova, Simona

AU - de Blay, Frédéric

AU - Bures, Peter

AU - Clausen, Michael

AU - Dubakiene, Ruta

AU - Gislason, David

AU - Jedrzejczak-Czechowicz, Monika

AU - Kowalski, Marek L.

AU - Knulst, André C.

AU - Kralimarkova, Tanya

AU - Le, Thuy-My

AU - Lovegrove, Alison

AU - Marsh, Justin

AU - Papadopoulos, Nikolaos G.

AU - Popov, Todor

AU - del Prado, Náyade

AU - Purohit, Ashok

AU - Reese, Gerald

AU - Reig, Isabel

AU - Seneviratne, Suranjith L.

AU - Sinaniotis, Athanasios

AU - Versteeg, Serge A.

AU - Vieths, Stefan

AU - Zwinderman, Aeilko H.

AU - Mills, Clare

AU - Lidholm, Jonas

AU - Hoffmann-Sommergruber, Karin

AU - Fernández-Rivas, Montserrat

AU - Ballmer-Weber, Barbara

AU - van Ree, Ronald

PY - 2015

Y1 - 2015

N2 - Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens. Establishing a molecular map of hazelnut allergy across Europe. In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP. Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen. In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established

AB - Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens. Establishing a molecular map of hazelnut allergy across Europe. In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP. Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen. In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established

U2 - 10.1016/j.jaci.2014.12.1949

DO - 10.1016/j.jaci.2014.12.1949

M3 - Article

C2 - 25772593

VL - 136

SP - 382

EP - 391

JO - Journal of allergy and clinical immunology

JF - Journal of allergy and clinical immunology

SN - 0091-6749

IS - 2

ER -

ID: 2590676