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Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation : A Matched Case-Control Study. / Zhang, Jian; Can, Anil; Lai, Pui Man Rosalind; Mukundan, Srinivasan; Castro, Victor M.; Dligach, Dmitriy; Finan, Sean; Gainer, Vivian S.; Shadick, Nancy A.; Savova, Guergana; Murphy, Shawn N.; Cai, Tianxi; Weiss, Scott T.; du, Rose.

In: Journal of stroke and cerebrovascular diseases, Vol. 31, No. 3, 106268, 01.03.2022.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Zhang, J, Can, A, Lai, PMR, Mukundan, S, Castro, VM, Dligach, D, Finan, S, Gainer, VS, Shadick, NA, Savova, G, Murphy, SN, Cai, T, Weiss, ST & du, R 2022, 'Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation: A Matched Case-Control Study', Journal of stroke and cerebrovascular diseases, vol. 31, no. 3, 106268. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106268

APA

Zhang, J., Can, A., Lai, P. M. R., Mukundan, S., Castro, V. M., Dligach, D., Finan, S., Gainer, V. S., Shadick, N. A., Savova, G., Murphy, S. N., Cai, T., Weiss, S. T., & du, R. (2022). Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation: A Matched Case-Control Study. Journal of stroke and cerebrovascular diseases, 31(3), [106268]. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106268

Vancouver

Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D et al. Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation: A Matched Case-Control Study. Journal of stroke and cerebrovascular diseases. 2022 Mar 1;31(3). 106268. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.106268

Author

Zhang, Jian ; Can, Anil ; Lai, Pui Man Rosalind ; Mukundan, Srinivasan ; Castro, Victor M. ; Dligach, Dmitriy ; Finan, Sean ; Gainer, Vivian S. ; Shadick, Nancy A. ; Savova, Guergana ; Murphy, Shawn N. ; Cai, Tianxi ; Weiss, Scott T. ; du, Rose. / Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation : A Matched Case-Control Study. In: Journal of stroke and cerebrovascular diseases. 2022 ; Vol. 31, No. 3.

BibTeX

@article{31127f78633546fb837cc9144866a5da,
title = "Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation: A Matched Case-Control Study",
abstract = "Objectives: The pathogenesis of intracranial aneurysms is multifactorial and includes genetic, environmental, and anatomic influences. We aimed to identify image-based morphological parameters that were associated with middle cerebral artery (MCA) bifurcation aneurysms. Materials and methods: We evaluated three-dimensional morphological parameters obtained from CT angiography (CTA) or digital subtraction angiography (DSA) from 317 patients with unilateral MCA bifurcation aneurysms diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016. We chose the contralateral unaffected MCA bifurcation as the control group, in order to control for genetic and environmental risk factors. Diameters and angles of surrounding parent and daughter vessels of 634 MCAs were examined. Results: Univariable and multivariable statistical analyses were performed to determine statistical significance. Sensitivity analyses with smaller (≤ 3 mm) aneurysms only and with angles excluded, were also performed. In a multivariable conditional logistic regression model we showed that smaller diameter size ratio (OR 0.0004, 95% CI 0.0001–0.15), larger daughter-daughter angles (OR 1.08, 95% CI 1.06–1.11) and larger parent-daughter angle ratios (OR 4.24, 95% CI 1.77–10.16) were significantly associated with MCA aneurysm presence after correcting for other variables. In order to account for possible changes to the vasculature by the aneurysm, a subgroup analysis of small aneurysms (≤ 3 mm) was performed and showed that the results were similar. Conclusions: Easily measurable morphological parameters of the surrounding vasculature of the MCA may provide objective metrics to assess MCA aneurysm formation risk in high-risk patients.",
keywords = "Aneurysm, Middle cerebral artery, Morphology, Subarachnoid hemorrhage",
author = "Jian Zhang and Anil Can and Lai, {Pui Man Rosalind} and Srinivasan Mukundan and Castro, {Victor M.} and Dmitriy Dligach and Sean Finan and Gainer, {Vivian S.} and Shadick, {Nancy A.} and Guergana Savova and Murphy, {Shawn N.} and Tianxi Cai and Weiss, {Scott T.} and Rose. du",
note = "Funding Information: This study was supported by Partners Personalized Medicine (RD), the National Institutes of Health ( U54 HG007963: TC and SM, U01 HG008685: SM, and R01 HG009174: SM ), and National Natural Science Foundation of China ( 81571121 ). Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2022",
month = mar,
day = "1",
doi = "10.1016/j.jstrokecerebrovasdis.2021.106268",
language = "English",
volume = "31",
journal = "Journal of stroke and cerebrovascular diseases",
issn = "1052-3057",
publisher = "W.B. Saunders Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation

T2 - A Matched Case-Control Study

AU - Zhang, Jian

AU - Can, Anil

AU - Lai, Pui Man Rosalind

AU - Mukundan, Srinivasan

AU - Castro, Victor M.

AU - Dligach, Dmitriy

AU - Finan, Sean

AU - Gainer, Vivian S.

AU - Shadick, Nancy A.

AU - Savova, Guergana

AU - Murphy, Shawn N.

AU - Cai, Tianxi

AU - Weiss, Scott T.

AU - du, Rose.

N1 - Funding Information: This study was supported by Partners Personalized Medicine (RD), the National Institutes of Health ( U54 HG007963: TC and SM, U01 HG008685: SM, and R01 HG009174: SM ), and National Natural Science Foundation of China ( 81571121 ). Publisher Copyright: © 2021 Elsevier Inc.

PY - 2022/3/1

Y1 - 2022/3/1

N2 - Objectives: The pathogenesis of intracranial aneurysms is multifactorial and includes genetic, environmental, and anatomic influences. We aimed to identify image-based morphological parameters that were associated with middle cerebral artery (MCA) bifurcation aneurysms. Materials and methods: We evaluated three-dimensional morphological parameters obtained from CT angiography (CTA) or digital subtraction angiography (DSA) from 317 patients with unilateral MCA bifurcation aneurysms diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016. We chose the contralateral unaffected MCA bifurcation as the control group, in order to control for genetic and environmental risk factors. Diameters and angles of surrounding parent and daughter vessels of 634 MCAs were examined. Results: Univariable and multivariable statistical analyses were performed to determine statistical significance. Sensitivity analyses with smaller (≤ 3 mm) aneurysms only and with angles excluded, were also performed. In a multivariable conditional logistic regression model we showed that smaller diameter size ratio (OR 0.0004, 95% CI 0.0001–0.15), larger daughter-daughter angles (OR 1.08, 95% CI 1.06–1.11) and larger parent-daughter angle ratios (OR 4.24, 95% CI 1.77–10.16) were significantly associated with MCA aneurysm presence after correcting for other variables. In order to account for possible changes to the vasculature by the aneurysm, a subgroup analysis of small aneurysms (≤ 3 mm) was performed and showed that the results were similar. Conclusions: Easily measurable morphological parameters of the surrounding vasculature of the MCA may provide objective metrics to assess MCA aneurysm formation risk in high-risk patients.

AB - Objectives: The pathogenesis of intracranial aneurysms is multifactorial and includes genetic, environmental, and anatomic influences. We aimed to identify image-based morphological parameters that were associated with middle cerebral artery (MCA) bifurcation aneurysms. Materials and methods: We evaluated three-dimensional morphological parameters obtained from CT angiography (CTA) or digital subtraction angiography (DSA) from 317 patients with unilateral MCA bifurcation aneurysms diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016. We chose the contralateral unaffected MCA bifurcation as the control group, in order to control for genetic and environmental risk factors. Diameters and angles of surrounding parent and daughter vessels of 634 MCAs were examined. Results: Univariable and multivariable statistical analyses were performed to determine statistical significance. Sensitivity analyses with smaller (≤ 3 mm) aneurysms only and with angles excluded, were also performed. In a multivariable conditional logistic regression model we showed that smaller diameter size ratio (OR 0.0004, 95% CI 0.0001–0.15), larger daughter-daughter angles (OR 1.08, 95% CI 1.06–1.11) and larger parent-daughter angle ratios (OR 4.24, 95% CI 1.77–10.16) were significantly associated with MCA aneurysm presence after correcting for other variables. In order to account for possible changes to the vasculature by the aneurysm, a subgroup analysis of small aneurysms (≤ 3 mm) was performed and showed that the results were similar. Conclusions: Easily measurable morphological parameters of the surrounding vasculature of the MCA may provide objective metrics to assess MCA aneurysm formation risk in high-risk patients.

KW - Aneurysm

KW - Middle cerebral artery

KW - Morphology

KW - Subarachnoid hemorrhage

UR - http://www.scopus.com/inward/record.url?scp=85122084409&partnerID=8YFLogxK

U2 - 10.1016/j.jstrokecerebrovasdis.2021.106268

DO - 10.1016/j.jstrokecerebrovasdis.2021.106268

M3 - Article

C2 - 34974241

VL - 31

JO - Journal of stroke and cerebrovascular diseases

JF - Journal of stroke and cerebrovascular diseases

SN - 1052-3057

IS - 3

M1 - 106268

ER -

ID: 21062084