Gender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus

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Gender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus. / Gianakos, Arianna L.; Williamson, Emilie R. C.; Mercer, Nathaniel et al.
In: Journal of foot and ankle surgery, Vol. 62, No. 1, 01.01.2023, p. 75-79.

Research output: Contribution to journal › Article › Academic › peer-review

BibTeX

@article{b42d889a64104e53b80f5af4b81e5e1b,

title = "Gender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus",

abstract = "Bone marrow stimulation (BMS) is indicated for patients who have symptomatic osteochondral lesions of the talus (OLT). Despite differences in ankle biomechanics and cartilage morphology between men and women, there is scant evidence examining whether these differences affect surgical outcomes. The purpose of this study was to compare the outcomes in men and women following BMS for OLTs. A retrospective analysis comparing female and male patients treated with BMS for OLT between 2007 and 2015 was performed. Clinical outcomes were evaluated using the Foot and Ankle Outcome Scores (FAOS) and Short-Form 12 (SF-12). Magnetic resonance imaging at final follow-up was evaluated with the modified magnetic resonance observation of cartilage repair tissue score. Thirty-one females and 38 males were included. In female patients, the mean FAOS pain score improved from 60 ± 16 preoperatively to 84 ± 8.9 at 1- to 2-year follow-up (p < .01), and then decreased to 80±13 at final follow-up at 3-4 years. In male patients, the mean FAOS pain score improved from 65±17 preoperatively to 83±9.2 at 1-2 year follow-up (p < .01), and then decreased to 76±14.6 at final follow-up at 3-4 years. Lateral lesions were more common in male patients. Medial lesions were more common in female patients. The outcomes following BMS in both female and male patients were good with no significant differences at short-term follow-up. FAOS scores in male patients were more likely to decrease after 1 to 2 years postsurgery, implying a possibly faster decline than in female patients.",

keywords = "4, BMS, bone marrow stimulation, gender, osteochondral lesion, sex, talus",

author = "Gianakos, {Arianna L.} and Williamson, {Emilie R. C.} and Nathaniel Mercer and Kerkhoffs, {Gino M.} and Kennedy, {John G.}",

note = "Funding Information: IRB approval. N/A. Yoshi Shimozono for part of the data collection and Eoghan Hurley for part of the data collection and manuscript formatting. Financial Disclosure: None reported. Conflict of Interest: Dr John G. Kennedy is a consultant for Arteriocyte, Inc and Arthrex Inc; is a board member for the International Society for Cartilage Repair of the Ankle, American Orthopaedic Foot and Ankle Society Awards and Scholarships Committee, International Cartilage Repair Society finance board. Dr Gino M.M.J. Kerkhoffs is a consultant for Arthrex Inc and is a board member of the International Society for Cartilage Repair of the Ankle. Dr Arianna Gianakos, Emilie Williamson, Nathaniel Mercer have no conflicts to disclose. Publisher Copyright: {\textcopyright} 2022 the American College of Foot and Ankle Surgeons",

year = "2023",

month = jan,

day = "1",

doi = "10.1053/j.jfas.2022.04.010",

language = "English",

volume = "62",

pages = "75--79",

journal = "Journal of foot and ankle surgery",

issn = "1067-2516",

publisher = "Academic Press Inc.",

number = "1",

}

RIS

TY - JOUR

T1 - Gender Differences May Exist in the Presentation, Mechanism of Injury and Outcomes Following Bone Marrow Stimulation for Osteochondral Lesions of the Talus

AU - Gianakos, Arianna L.

AU - Williamson, Emilie R. C.

AU - Mercer, Nathaniel

AU - Kerkhoffs, Gino M.

AU - Kennedy, John G.

N1 - Funding Information: IRB approval. N/A. Yoshi Shimozono for part of the data collection and Eoghan Hurley for part of the data collection and manuscript formatting. Financial Disclosure: None reported. Conflict of Interest: Dr John G. Kennedy is a consultant for Arteriocyte, Inc and Arthrex Inc; is a board member for the International Society for Cartilage Repair of the Ankle, American Orthopaedic Foot and Ankle Society Awards and Scholarships Committee, International Cartilage Repair Society finance board. Dr Gino M.M.J. Kerkhoffs is a consultant for Arthrex Inc and is a board member of the International Society for Cartilage Repair of the Ankle. Dr Arianna Gianakos, Emilie Williamson, Nathaniel Mercer have no conflicts to disclose. Publisher Copyright: © 2022 the American College of Foot and Ankle Surgeons

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Bone marrow stimulation (BMS) is indicated for patients who have symptomatic osteochondral lesions of the talus (OLT). Despite differences in ankle biomechanics and cartilage morphology between men and women, there is scant evidence examining whether these differences affect surgical outcomes. The purpose of this study was to compare the outcomes in men and women following BMS for OLTs. A retrospective analysis comparing female and male patients treated with BMS for OLT between 2007 and 2015 was performed. Clinical outcomes were evaluated using the Foot and Ankle Outcome Scores (FAOS) and Short-Form 12 (SF-12). Magnetic resonance imaging at final follow-up was evaluated with the modified magnetic resonance observation of cartilage repair tissue score. Thirty-one females and 38 males were included. In female patients, the mean FAOS pain score improved from 60 ± 16 preoperatively to 84 ± 8.9 at 1- to 2-year follow-up (p < .01), and then decreased to 80±13 at final follow-up at 3-4 years. In male patients, the mean FAOS pain score improved from 65±17 preoperatively to 83±9.2 at 1-2 year follow-up (p < .01), and then decreased to 76±14.6 at final follow-up at 3-4 years. Lateral lesions were more common in male patients. Medial lesions were more common in female patients. The outcomes following BMS in both female and male patients were good with no significant differences at short-term follow-up. FAOS scores in male patients were more likely to decrease after 1 to 2 years postsurgery, implying a possibly faster decline than in female patients.

AB - Bone marrow stimulation (BMS) is indicated for patients who have symptomatic osteochondral lesions of the talus (OLT). Despite differences in ankle biomechanics and cartilage morphology between men and women, there is scant evidence examining whether these differences affect surgical outcomes. The purpose of this study was to compare the outcomes in men and women following BMS for OLTs. A retrospective analysis comparing female and male patients treated with BMS for OLT between 2007 and 2015 was performed. Clinical outcomes were evaluated using the Foot and Ankle Outcome Scores (FAOS) and Short-Form 12 (SF-12). Magnetic resonance imaging at final follow-up was evaluated with the modified magnetic resonance observation of cartilage repair tissue score. Thirty-one females and 38 males were included. In female patients, the mean FAOS pain score improved from 60 ± 16 preoperatively to 84 ± 8.9 at 1- to 2-year follow-up (p < .01), and then decreased to 80±13 at final follow-up at 3-4 years. In male patients, the mean FAOS pain score improved from 65±17 preoperatively to 83±9.2 at 1-2 year follow-up (p < .01), and then decreased to 76±14.6 at final follow-up at 3-4 years. Lateral lesions were more common in male patients. Medial lesions were more common in female patients. The outcomes following BMS in both female and male patients were good with no significant differences at short-term follow-up. FAOS scores in male patients were more likely to decrease after 1 to 2 years postsurgery, implying a possibly faster decline than in female patients.

KW - 4

KW - BMS

KW - bone marrow stimulation

KW - gender

KW - osteochondral lesion

KW - sex

KW - talus

UR - http://www.scopus.com/inward/record.url?scp=85131369320&partnerID=8YFLogxK

U2 - 10.1053/j.jfas.2022.04.010

DO - 10.1053/j.jfas.2022.04.010

M3 - Article

C2 - 35659478

VL - 62

SP - 75

EP - 79

JO - Journal of foot and ankle surgery

JF - Journal of foot and ankle surgery

SN - 1067-2516

IS - 1

ER -

ID: 24148903

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