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FiO2 predicts outcome in infants with respiratory syncytial virus-induced acute respiratory distress syndrome. / Schene, Kiry M.; van den Berg, Elske; Wösten-van Asperen, Roelie M.; van Rijn, Rick R.; Bos, Albert P.; van Woensel, Job B. M.

In: Pediatric pulmonology, Vol. 49, No. 11, 2014, p. 1138-1144.

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@article{3b093d9890ed45e8b1f769bd3c228368,
title = "FiO2 predicts outcome in infants with respiratory syncytial virus-induced acute respiratory distress syndrome",
abstract = "Respiratory syncytial virus (RSV) infection can progress to acute respiratory distress syndrome (ARDS) in infants. ARDS is a life-threatening condition that is characterized by severe hypoxemia, defined as PaO(2)/FiO(2) ratio <300 mmHg. This ratio is used in many trials as the sole oxygenation criterion for ARDS. Recently, however, it has been shown in adults with ARDS that FiO(2), independently of the PaO(2)/FiO(2) ratio predicts mortality. Because epidemiology and outcome of ARDS differ strongly between children and adults, we determined if FiO(2) on admission (baseline FiO(2)) independently predicted the duration of mechanical ventilation (MV) and length of stay (LOS) in the pediatric intensive care unit (PICU) in infants with RSV-induced ARDS. Retrospective observational study. A 14-bed pediatric intensive care unit. One hundred twenty-nine mechanically ventilated infants with RSV-induced ARDS. None. Independent predictors for outcome, including baseline FiO(2) and PEEP, were analyzed using the cox regression model. Endpoints were duration of MV and LOS in the PICU. A higher baseline FiO(2) was independently associated with a longer duration of MV (HR 0.12, CI 0.02-0.87, P = 0.036) and increased LOS in the PICU (HR 0.09, CI 0.01-0.57, P = 0.023). Neither baseline PEEP nor PaO(2)/FiO(2) ratio correlated with outcome. FiO(2) level independently predicted outcome in infants with RSV-induced ARDS, whereas both PEEP and the PaO(2)/FiO(2) ratio did not. This suggests that FiO(2) should be taken into account in defining disease severity in infants with RSV-induced ARDS",
author = "Schene, {Kiry M.} and {van den Berg}, Elske and {W{\"o}sten-van Asperen}, {Roelie M.} and {van Rijn}, {Rick R.} and Bos, {Albert P.} and {van Woensel}, {Job B. M.}",
year = "2014",
doi = "10.1002/ppul.22974",
language = "English",
volume = "49",
pages = "1138--1144",
journal = "Pediatric pulmonology",
issn = "8755-6863",
publisher = "Wiley-Liss Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - FiO2 predicts outcome in infants with respiratory syncytial virus-induced acute respiratory distress syndrome

AU - Schene, Kiry M.

AU - van den Berg, Elske

AU - Wösten-van Asperen, Roelie M.

AU - van Rijn, Rick R.

AU - Bos, Albert P.

AU - van Woensel, Job B. M.

PY - 2014

Y1 - 2014

N2 - Respiratory syncytial virus (RSV) infection can progress to acute respiratory distress syndrome (ARDS) in infants. ARDS is a life-threatening condition that is characterized by severe hypoxemia, defined as PaO(2)/FiO(2) ratio <300 mmHg. This ratio is used in many trials as the sole oxygenation criterion for ARDS. Recently, however, it has been shown in adults with ARDS that FiO(2), independently of the PaO(2)/FiO(2) ratio predicts mortality. Because epidemiology and outcome of ARDS differ strongly between children and adults, we determined if FiO(2) on admission (baseline FiO(2)) independently predicted the duration of mechanical ventilation (MV) and length of stay (LOS) in the pediatric intensive care unit (PICU) in infants with RSV-induced ARDS. Retrospective observational study. A 14-bed pediatric intensive care unit. One hundred twenty-nine mechanically ventilated infants with RSV-induced ARDS. None. Independent predictors for outcome, including baseline FiO(2) and PEEP, were analyzed using the cox regression model. Endpoints were duration of MV and LOS in the PICU. A higher baseline FiO(2) was independently associated with a longer duration of MV (HR 0.12, CI 0.02-0.87, P = 0.036) and increased LOS in the PICU (HR 0.09, CI 0.01-0.57, P = 0.023). Neither baseline PEEP nor PaO(2)/FiO(2) ratio correlated with outcome. FiO(2) level independently predicted outcome in infants with RSV-induced ARDS, whereas both PEEP and the PaO(2)/FiO(2) ratio did not. This suggests that FiO(2) should be taken into account in defining disease severity in infants with RSV-induced ARDS

AB - Respiratory syncytial virus (RSV) infection can progress to acute respiratory distress syndrome (ARDS) in infants. ARDS is a life-threatening condition that is characterized by severe hypoxemia, defined as PaO(2)/FiO(2) ratio <300 mmHg. This ratio is used in many trials as the sole oxygenation criterion for ARDS. Recently, however, it has been shown in adults with ARDS that FiO(2), independently of the PaO(2)/FiO(2) ratio predicts mortality. Because epidemiology and outcome of ARDS differ strongly between children and adults, we determined if FiO(2) on admission (baseline FiO(2)) independently predicted the duration of mechanical ventilation (MV) and length of stay (LOS) in the pediatric intensive care unit (PICU) in infants with RSV-induced ARDS. Retrospective observational study. A 14-bed pediatric intensive care unit. One hundred twenty-nine mechanically ventilated infants with RSV-induced ARDS. None. Independent predictors for outcome, including baseline FiO(2) and PEEP, were analyzed using the cox regression model. Endpoints were duration of MV and LOS in the PICU. A higher baseline FiO(2) was independently associated with a longer duration of MV (HR 0.12, CI 0.02-0.87, P = 0.036) and increased LOS in the PICU (HR 0.09, CI 0.01-0.57, P = 0.023). Neither baseline PEEP nor PaO(2)/FiO(2) ratio correlated with outcome. FiO(2) level independently predicted outcome in infants with RSV-induced ARDS, whereas both PEEP and the PaO(2)/FiO(2) ratio did not. This suggests that FiO(2) should be taken into account in defining disease severity in infants with RSV-induced ARDS

U2 - 10.1002/ppul.22974

DO - 10.1002/ppul.22974

M3 - Article

C2 - 24347224

VL - 49

SP - 1138

EP - 1144

JO - Pediatric pulmonology

JF - Pediatric pulmonology

SN - 8755-6863

IS - 11

ER -

ID: 2274995