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FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming. / Hansen, Ivo S.; Krabbendam, Lisette; Bernink, Jochem H. et al.

In: Nature communications, Vol. 9, No. 1, 2018, p. 863.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Hansen, IS, Krabbendam, L, Bernink, JH, Loayza-Puch, F, Hoepel, W, van Burgsteden, JA, Kuijper, EC, Buskens, CJ, Bemelman, WA, Zaat, SAJ, Agami, R, Vidarsson, G, van den Brink, GR, de Jong, EC, Wildenberg, ME, Baeten, DLP, Everts, B & den Dunnen, J 2018, 'FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming', Nature communications, vol. 9, no. 1, pp. 863. https://doi.org/10.1038/s41467-018-03318-5

APA

Hansen, I. S., Krabbendam, L., Bernink, J. H., Loayza-Puch, F., Hoepel, W., van Burgsteden, J. A., Kuijper, E. C., Buskens, C. J., Bemelman, W. A., Zaat, S. A. J., Agami, R., Vidarsson, G., van den Brink, G. R., de Jong, E. C., Wildenberg, M. E., Baeten, D. L. P., Everts, B., & den Dunnen, J. (2018). FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming. Nature communications, 9(1), 863. https://doi.org/10.1038/s41467-018-03318-5

Vancouver

Hansen IS, Krabbendam L, Bernink JH, Loayza-Puch F, Hoepel W, van Burgsteden JA et al. FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming. Nature communications. 2018;9(1):863. doi: 10.1038/s41467-018-03318-5

Author

Hansen, Ivo S. ; Krabbendam, Lisette ; Bernink, Jochem H. et al. / FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming. In: Nature communications. 2018 ; Vol. 9, No. 1. pp. 863.

BibTeX

@article{0fe7356c68dc4b2280d4ccfb16036673,
title = "FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming",
abstract = "+DCs. These cells then enhance inflammation by promoting Th17 responses and activating human intestinal innate lymphoid cells 3. Moreover, FcαRI-induced cytokine production is orchestrated via upregulation of cytokine translation and caspase-1 activation, which is dependent on glycolytic reprogramming mediated by kinases Syk, PI3K and TBK1-IKKε. Our data suggest that the formation of IgA-IC in the human intestine provides an environmental cue for the conversion of a tolerogenic to an inflammatory response",
author = "Hansen, {Ivo S.} and Lisette Krabbendam and Bernink, {Jochem H.} and Fabricio Loayza-Puch and Willianne Hoepel and {van Burgsteden}, {Johan A.} and Kuijper, {Elsa C.} and Buskens, {Christianne J.} and Bemelman, {Willem A.} and Zaat, {Sebastiaan A. J.} and Reuven Agami and Gestur Vidarsson and {van den Brink}, {Gijs R.} and {de Jong}, {Esther C.} and Wildenberg, {Manon E.} and Baeten, {Dominique L. P.} and Bart Everts and {den Dunnen}, Jeroen",
year = "2018",
doi = "10.1038/s41467-018-03318-5",
language = "English",
volume = "9",
pages = "863",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

AU - Hansen, Ivo S.

AU - Krabbendam, Lisette

AU - Bernink, Jochem H.

AU - Loayza-Puch, Fabricio

AU - Hoepel, Willianne

AU - van Burgsteden, Johan A.

AU - Kuijper, Elsa C.

AU - Buskens, Christianne J.

AU - Bemelman, Willem A.

AU - Zaat, Sebastiaan A. J.

AU - Agami, Reuven

AU - Vidarsson, Gestur

AU - van den Brink, Gijs R.

AU - de Jong, Esther C.

AU - Wildenberg, Manon E.

AU - Baeten, Dominique L. P.

AU - Everts, Bart

AU - den Dunnen, Jeroen

PY - 2018

Y1 - 2018

N2 - +DCs. These cells then enhance inflammation by promoting Th17 responses and activating human intestinal innate lymphoid cells 3. Moreover, FcαRI-induced cytokine production is orchestrated via upregulation of cytokine translation and caspase-1 activation, which is dependent on glycolytic reprogramming mediated by kinases Syk, PI3K and TBK1-IKKε. Our data suggest that the formation of IgA-IC in the human intestine provides an environmental cue for the conversion of a tolerogenic to an inflammatory response

AB - +DCs. These cells then enhance inflammation by promoting Th17 responses and activating human intestinal innate lymphoid cells 3. Moreover, FcαRI-induced cytokine production is orchestrated via upregulation of cytokine translation and caspase-1 activation, which is dependent on glycolytic reprogramming mediated by kinases Syk, PI3K and TBK1-IKKε. Our data suggest that the formation of IgA-IC in the human intestine provides an environmental cue for the conversion of a tolerogenic to an inflammatory response

U2 - 10.1038/s41467-018-03318-5

DO - 10.1038/s41467-018-03318-5

M3 - Article

C2 - 29491406

VL - 9

SP - 863

JO - Nature communications

JF - Nature communications

SN - 2041-1723

IS - 1

ER -

ID: 4637232