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Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes. / Faber, Jaeike W.; Wüst, Rob C.I.; Dierx, Inge et al.

In: iScience, Vol. 25, No. 11, 105393, 18.11.2022.

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Vancouver

Faber JW, Wüst RCI, Dierx I, Hummelink JA, Kuster DWD, Nollet E et al. Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes. iScience. 2022 Nov 18;25(11). 105393. https://doi.org/10.1016/j.isci.2022.105393

Author

Faber, Jaeike W. ; Wüst, Rob C.I. ; Dierx, Inge et al. / Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes. In: iScience. 2022 ; Vol. 25, No. 11.

BibTeX

@article{54c8d007c2d64f4280f6ad0d9c86f234,
title = "Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes",
abstract = "Trabecular myocardium makes up most of the ventricular wall of the human embryo. A process of compaction in the fetal period presumably changes ventricular wall morphology by converting ostensibly weaker trabecular myocardium into stronger compact myocardium. Using developmental series of embryonic and fetal humans, mice and chickens, we show ventricular morphogenesis is driven by differential rates of growth of trabecular and compact layers rather than a process of compaction. In mouse, fetal cardiomyocytes are relatively weak but adult cardiomyocytes from the trabecular and compact layer show an equally large force generating capacity. In fetal and adult humans, trabecular and compact myocardium are not different in abundance of immunohistochemically detected vascular, mitochondrial and sarcomeric proteins. Similar findings are made in human excessive trabeculation, a congenital malformation. In conclusion, trabecular and compact myocardium is equally equipped for force production and their proportions are determined by differential growth rates rather than by compaction.",
keywords = "Anatomy, Biology of human development, Developmental anatomy, Developmental biology, Mechanobiology, Medical imaging, Medicine",
author = "Faber, {Jaeike W.} and W{\"u}st, {Rob C.I.} and Inge Dierx and Hummelink, {Janneke A.} and Kuster, {Diederik W.D.} and Edgar Nollet and Moorman, {Antoon F.M.} and Dami{\'a}n S{\'a}nchez-Quintana and {van der Wal}, {Allard C.} and Christoffels, {Vincent M.} and Bjarke Jensen",
note = "Funding Information: We would like to thank Fernanda Bosada, Rajiv Mohan, Antoinette van Ouwerkerk, Corrie de Gier-de Vries and Maurice van den Hoff for their assistance. This study was funded by an Amsterdam UMC grant 170421/2017.03.042 obtained by Antoon F. M. Moorman. Conceptualization: J.W.F. and B.J.; Methodology: J.W.F. D.W.D. K. and B.J.; Formal analysis and investigation: J.W.F. R.C.I.W, I.D. J.A.H. and E.N.; Writing – original draft preparation: J.W.F. and B.J.; Writing – review and editing: J.W.F. R.C.I.W. I.D. J.A.H, D.W.D.K. E.N. A.F.M.M. A.V-D.W. V.M.C, and B.J.; Funding acquisition: A.F.M.M.; Resources: D.W.D.K. D.S-Q. A.V-D.W. and V.C.; Supervision: B.J. and V.M.C. The authors declare no competing interests. Funding Information: This study was funded by an Amsterdam UMC grant 170421/2017.03.042 obtained by Antoon F. M. Moorman. Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = nov,
day = "18",
doi = "10.1016/j.isci.2022.105393",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Equal force generation potential of trabecular and compact wall ventricular cardiomyocytes

AU - Faber, Jaeike W.

AU - Wüst, Rob C.I.

AU - Dierx, Inge

AU - Hummelink, Janneke A.

AU - Kuster, Diederik W.D.

AU - Nollet, Edgar

AU - Moorman, Antoon F.M.

AU - Sánchez-Quintana, Damián

AU - van der Wal, Allard C.

AU - Christoffels, Vincent M.

AU - Jensen, Bjarke

N1 - Funding Information: We would like to thank Fernanda Bosada, Rajiv Mohan, Antoinette van Ouwerkerk, Corrie de Gier-de Vries and Maurice van den Hoff for their assistance. This study was funded by an Amsterdam UMC grant 170421/2017.03.042 obtained by Antoon F. M. Moorman. Conceptualization: J.W.F. and B.J.; Methodology: J.W.F. D.W.D. K. and B.J.; Formal analysis and investigation: J.W.F. R.C.I.W, I.D. J.A.H. and E.N.; Writing – original draft preparation: J.W.F. and B.J.; Writing – review and editing: J.W.F. R.C.I.W. I.D. J.A.H, D.W.D.K. E.N. A.F.M.M. A.V-D.W. V.M.C, and B.J.; Funding acquisition: A.F.M.M.; Resources: D.W.D.K. D.S-Q. A.V-D.W. and V.C.; Supervision: B.J. and V.M.C. The authors declare no competing interests. Funding Information: This study was funded by an Amsterdam UMC grant 170421/2017.03.042 obtained by Antoon F. M. Moorman. Publisher Copyright: © 2022 The Author(s)

PY - 2022/11/18

Y1 - 2022/11/18

N2 - Trabecular myocardium makes up most of the ventricular wall of the human embryo. A process of compaction in the fetal period presumably changes ventricular wall morphology by converting ostensibly weaker trabecular myocardium into stronger compact myocardium. Using developmental series of embryonic and fetal humans, mice and chickens, we show ventricular morphogenesis is driven by differential rates of growth of trabecular and compact layers rather than a process of compaction. In mouse, fetal cardiomyocytes are relatively weak but adult cardiomyocytes from the trabecular and compact layer show an equally large force generating capacity. In fetal and adult humans, trabecular and compact myocardium are not different in abundance of immunohistochemically detected vascular, mitochondrial and sarcomeric proteins. Similar findings are made in human excessive trabeculation, a congenital malformation. In conclusion, trabecular and compact myocardium is equally equipped for force production and their proportions are determined by differential growth rates rather than by compaction.

AB - Trabecular myocardium makes up most of the ventricular wall of the human embryo. A process of compaction in the fetal period presumably changes ventricular wall morphology by converting ostensibly weaker trabecular myocardium into stronger compact myocardium. Using developmental series of embryonic and fetal humans, mice and chickens, we show ventricular morphogenesis is driven by differential rates of growth of trabecular and compact layers rather than a process of compaction. In mouse, fetal cardiomyocytes are relatively weak but adult cardiomyocytes from the trabecular and compact layer show an equally large force generating capacity. In fetal and adult humans, trabecular and compact myocardium are not different in abundance of immunohistochemically detected vascular, mitochondrial and sarcomeric proteins. Similar findings are made in human excessive trabeculation, a congenital malformation. In conclusion, trabecular and compact myocardium is equally equipped for force production and their proportions are determined by differential growth rates rather than by compaction.

KW - Anatomy

KW - Biology of human development

KW - Developmental anatomy

KW - Developmental biology

KW - Mechanobiology

KW - Medical imaging

KW - Medicine

UR - http://www.scopus.com/inward/record.url?scp=85140982090&partnerID=8YFLogxK

U2 - 10.1016/j.isci.2022.105393

DO - 10.1016/j.isci.2022.105393

M3 - Article

C2 - 36345331

AN - SCOPUS:85140982090

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 11

M1 - 105393

ER -

ID: 26687028