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Epigenome-wide association study for perceived discrimination among sub-Saharan African migrants in Europe - the RODAM study. / van der Laan, Loes C.; Meeks, Karlijn A. C.; Chilunga, Felix P. et al.
In: Scientific reports, Vol. 10, No. 1, 4919, 01.12.2020.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Epigenome-wide association study for perceived discrimination among sub-Saharan African migrants in Europe - the RODAM study
AU - van der Laan, Loes C.
AU - Meeks, Karlijn A. C.
AU - Chilunga, Felix P.
AU - Agyemang, Charles
AU - Venema, Andrea
AU - Mannens, Marcel M. A. M.
AU - Zafarmand, Mohammad H.
AU - Klipstein-Grobusch, Kerstin
AU - Smeeth, Liam
AU - Adeyemo, Adebowale
AU - Henneman, Peter
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Sub-Saharan African (SSA) migrants in Europe experience psychosocial stressors, such as perceived discrimination (PD). The effect of such a stressor on health could potentially be mediated via epigenetics. In this study we performed an epigenome-wide association study (EWAS) to assess the association between levels of PD with genome-wide DNA methylation profiles in SSA migrants. The Illumina 450 K DNA-methylation array was used on whole blood samples of 340 Ghanaian adults residing in three European cities from the cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) study. PD was assessed using sum scores of the Everyday Discrimination Scale (EDS). Differentially methylated positions and regions (DMPs and DMRs) were identified through linear regression analysis. Two hypo-methylated DMPs, namely cg13986138 (CYFIP1) and cg10316525(ANKRD63), were found to be associated with PD. DMR analysis identified 47 regions associated with the PD. To the best of our knowledge, this survey is the first EWAS for PD in first generation SSA migrants. We identified two DMPs associated with PD. Whether these associations underlie a consequence or causal effect within the scope of biological functionality needs additional research.
AB - Sub-Saharan African (SSA) migrants in Europe experience psychosocial stressors, such as perceived discrimination (PD). The effect of such a stressor on health could potentially be mediated via epigenetics. In this study we performed an epigenome-wide association study (EWAS) to assess the association between levels of PD with genome-wide DNA methylation profiles in SSA migrants. The Illumina 450 K DNA-methylation array was used on whole blood samples of 340 Ghanaian adults residing in three European cities from the cross-sectional Research on Obesity and Diabetes among African Migrants (RODAM) study. PD was assessed using sum scores of the Everyday Discrimination Scale (EDS). Differentially methylated positions and regions (DMPs and DMRs) were identified through linear regression analysis. Two hypo-methylated DMPs, namely cg13986138 (CYFIP1) and cg10316525(ANKRD63), were found to be associated with PD. DMR analysis identified 47 regions associated with the PD. To the best of our knowledge, this survey is the first EWAS for PD in first generation SSA migrants. We identified two DMPs associated with PD. Whether these associations underlie a consequence or causal effect within the scope of biological functionality needs additional research.
UR - http://www.scopus.com/inward/record.url?scp=85082080183&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-61649-0
DO - 10.1038/s41598-020-61649-0
M3 - Article
C2 - 32188935
VL - 10
JO - Scientific reports
JF - Scientific reports
SN - 2045-2322
IS - 1
M1 - 4919
ER -
ID: 11236382