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Echocardiographic Analysis of Cardiac Function after Infarction in Mice: Validation of Single-Plane Long-Axis View Measurements and the Bi-Plane Simpson Method. / Heinen, Andre; Raupach, Annika; Behmenburg, Friederike et al.

In: Ultrasound in medicine & biology, Vol. 44, No. 7, 2018, p. 1544-1555.

Research output: Contribution to journalArticleAcademicpeer-review

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Heinen, A, Raupach, A, Behmenburg, F, Hölscher, N, Flögel, U, Kelm, M, Kaisers, W, Nederlof, R, Huhn, R & Gödecke, A 2018, 'Echocardiographic Analysis of Cardiac Function after Infarction in Mice: Validation of Single-Plane Long-Axis View Measurements and the Bi-Plane Simpson Method', Ultrasound in medicine & biology, vol. 44, no. 7, pp. 1544-1555. https://doi.org/10.1016/j.ultrasmedbio.2018.03.020

APA

Vancouver

Author

Heinen, Andre ; Raupach, Annika ; Behmenburg, Friederike et al. / Echocardiographic Analysis of Cardiac Function after Infarction in Mice: Validation of Single-Plane Long-Axis View Measurements and the Bi-Plane Simpson Method. In: Ultrasound in medicine & biology. 2018 ; Vol. 44, No. 7. pp. 1544-1555.

BibTeX

@article{06983cf08cca426f9e74a84299fedf5c,
title = "Echocardiographic Analysis of Cardiac Function after Infarction in Mice: Validation of Single-Plane Long-Axis View Measurements and the Bi-Plane Simpson Method",
abstract = "Although echocardiography is commonly used to analyze cardiac function in small animal models of cardiac remodeling after myocardial infarction, the different echocardiographic methods are validated poorly. End-diastolic volume, end-systolic volume and ejection fraction were analyzed using either standard single-plane analysis from parasternal long-axis B-mode views (PSLAX) or the bi-plane Simpson method (using PSLAX and three short-axis views) and validated using magnetic resonance imaging as standard. Ejection fraction measured by PSLAX was moderately correlated with a coefficient of R2 = 0.49. The standard deviation of residuals was 9.91. Simpson analysis revealed an improved correlation coefficient of R2 = 0.77 and a reduction in standard deviation of residuals by 45% (5.45 vs. 9.92, p = 0.014). Subgroup analysis revealed that the high variation in PSLAX is due to changes in ventricular geometry after myocardial infarction. Our results indicate that the bi-plane Simpson method is advantageous for the assessment of cardiac function after myocardial infarction.",
author = "Andre Heinen and Annika Raupach and Friederike Behmenburg and Nina H{\"o}lscher and Ulrich Fl{\"o}gel and Malte Kelm and Wolfgang Kaisers and Rianne Nederlof and Ragnar Huhn and Axel G{\"o}decke",
year = "2018",
doi = "10.1016/j.ultrasmedbio.2018.03.020",
language = "English",
volume = "44",
pages = "1544--1555",
journal = "Ultrasound in medicine & biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "7",

}

RIS

TY - JOUR

T1 - Echocardiographic Analysis of Cardiac Function after Infarction in Mice: Validation of Single-Plane Long-Axis View Measurements and the Bi-Plane Simpson Method

AU - Heinen, Andre

AU - Raupach, Annika

AU - Behmenburg, Friederike

AU - Hölscher, Nina

AU - Flögel, Ulrich

AU - Kelm, Malte

AU - Kaisers, Wolfgang

AU - Nederlof, Rianne

AU - Huhn, Ragnar

AU - Gödecke, Axel

PY - 2018

Y1 - 2018

N2 - Although echocardiography is commonly used to analyze cardiac function in small animal models of cardiac remodeling after myocardial infarction, the different echocardiographic methods are validated poorly. End-diastolic volume, end-systolic volume and ejection fraction were analyzed using either standard single-plane analysis from parasternal long-axis B-mode views (PSLAX) or the bi-plane Simpson method (using PSLAX and three short-axis views) and validated using magnetic resonance imaging as standard. Ejection fraction measured by PSLAX was moderately correlated with a coefficient of R2 = 0.49. The standard deviation of residuals was 9.91. Simpson analysis revealed an improved correlation coefficient of R2 = 0.77 and a reduction in standard deviation of residuals by 45% (5.45 vs. 9.92, p = 0.014). Subgroup analysis revealed that the high variation in PSLAX is due to changes in ventricular geometry after myocardial infarction. Our results indicate that the bi-plane Simpson method is advantageous for the assessment of cardiac function after myocardial infarction.

AB - Although echocardiography is commonly used to analyze cardiac function in small animal models of cardiac remodeling after myocardial infarction, the different echocardiographic methods are validated poorly. End-diastolic volume, end-systolic volume and ejection fraction were analyzed using either standard single-plane analysis from parasternal long-axis B-mode views (PSLAX) or the bi-plane Simpson method (using PSLAX and three short-axis views) and validated using magnetic resonance imaging as standard. Ejection fraction measured by PSLAX was moderately correlated with a coefficient of R2 = 0.49. The standard deviation of residuals was 9.91. Simpson analysis revealed an improved correlation coefficient of R2 = 0.77 and a reduction in standard deviation of residuals by 45% (5.45 vs. 9.92, p = 0.014). Subgroup analysis revealed that the high variation in PSLAX is due to changes in ventricular geometry after myocardial infarction. Our results indicate that the bi-plane Simpson method is advantageous for the assessment of cardiac function after myocardial infarction.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046144535&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/29706407

U2 - 10.1016/j.ultrasmedbio.2018.03.020

DO - 10.1016/j.ultrasmedbio.2018.03.020

M3 - Article

C2 - 29706407

VL - 44

SP - 1544

EP - 1555

JO - Ultrasound in medicine & biology

JF - Ultrasound in medicine & biology

SN - 0301-5629

IS - 7

ER -

ID: 5754023