DNA methylation as the link between migration and the major noncommunicable diseases: The RODAM study

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DNA methylation as the link between migration and the major noncommunicable diseases: The RODAM study. / Chilunga, Felix P.; Henneman, Peter ; Venema, Andrea et al.

In: Epigenomics, Vol. 13, No. 9, 01.05.2021, p. 653-666.

Research output: Contribution to journal › Article › Academic › peer-review

BibTeX

@article{19383a7e8eb14c8aa11ea68a9d5e4f58,

title = "DNA methylation as the link between migration and the major noncommunicable diseases: The RODAM study",

abstract = "Aim: We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians. Materials & methods: We used the Illumina Infinium{\textregistered} HumanMethylation450 BeadChip to profile DNAm of 712 Ghanaians in whole blood. We used linear models to detect differentially methylated positions (DMPs) associated with migration. We performed multiple post hoc analyses to validate our findings. Results: We identified 13 DMPs associated with migration (delta-beta values: 0.2-4.5%). Seven DMPs in CPLX2, EIF4E3, MEF2D, TLX3, ST8SIA1, ANG and CHRM3 were independent of extrinsic genomic influences in public databases. Two DMPs in NLRC5 were associated with duration of stay in Europe among migrants. All DMPs were biologically linked to migration-related factors. Conclusion: Our findings provide the first insights into DNAm differences between migrants and non-migrants.",

keywords = "DNA methylation, RODAM study, migrants, noncommunicable diseases, sub-Saharan Africans",

author = "Chilunga, {Felix P.} and Peter Henneman and Andrea Venema and Meeks, {Karlijn Ac} and Gonzalez, {Juan R.} and Carlos Ruiz-Arenas and Ana Requena-M{\'e}ndez and Erik Beune and Joachim Spranger and Liam Smeeth and Silver Bahendeka and Ellis Owusu-Dabo and Kerstin Klipstein-Grobusch and Adebowale Adeyemo and Mannens, {Marcel Mam} and Charles Agyemang",

note = "Funding Information: This work was supported by the European Commission under the Framework Programme (grant no.: 278901) and European Research Council Consolidation (grant no.: 772244). FP Chilunga is supported by the Erasmus Mundus Joint Doctorate Programme of the European Union through the Amsterdam Institute of Global Health and Development (AIGHD; grant agreement 2015– 1595). A.A. and K.A.C.M. are supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2021 Future Medicine Ltdl.",

year = "2021",

month = may,

day = "1",

doi = "10.2217/epi-2020-0329",

language = "English",

volume = "13",

pages = "653--666",

journal = "Epigenomics",

issn = "1750-1911",

publisher = "Future Medicine Ltd.",

number = "9",

}

RIS

TY - JOUR

T1 - DNA methylation as the link between migration and the major noncommunicable diseases: The RODAM study

AU - Chilunga, Felix P.

AU - Henneman, Peter

AU - Venema, Andrea

AU - Meeks, Karlijn Ac

AU - Gonzalez, Juan R.

AU - Ruiz-Arenas, Carlos

AU - Requena-Méndez, Ana

AU - Beune, Erik

AU - Spranger, Joachim

AU - Smeeth, Liam

AU - Bahendeka, Silver

AU - Owusu-Dabo, Ellis

AU - Klipstein-Grobusch, Kerstin

AU - Adeyemo, Adebowale

AU - Mannens, Marcel Mam

AU - Agyemang, Charles

N1 - Funding Information: This work was supported by the European Commission under the Framework Programme (grant no.: 278901) and European Research Council Consolidation (grant no.: 772244). FP Chilunga is supported by the Erasmus Mundus Joint Doctorate Programme of the European Union through the Amsterdam Institute of Global Health and Development (AIGHD; grant agreement 2015– 1595). A.A. and K.A.C.M. are supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2021 Future Medicine Ltdl.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Aim: We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians. Materials & methods: We used the Illumina Infinium® HumanMethylation450 BeadChip to profile DNAm of 712 Ghanaians in whole blood. We used linear models to detect differentially methylated positions (DMPs) associated with migration. We performed multiple post hoc analyses to validate our findings. Results: We identified 13 DMPs associated with migration (delta-beta values: 0.2-4.5%). Seven DMPs in CPLX2, EIF4E3, MEF2D, TLX3, ST8SIA1, ANG and CHRM3 were independent of extrinsic genomic influences in public databases. Two DMPs in NLRC5 were associated with duration of stay in Europe among migrants. All DMPs were biologically linked to migration-related factors. Conclusion: Our findings provide the first insights into DNAm differences between migrants and non-migrants.

AB - Aim: We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians. Materials & methods: We used the Illumina Infinium® HumanMethylation450 BeadChip to profile DNAm of 712 Ghanaians in whole blood. We used linear models to detect differentially methylated positions (DMPs) associated with migration. We performed multiple post hoc analyses to validate our findings. Results: We identified 13 DMPs associated with migration (delta-beta values: 0.2-4.5%). Seven DMPs in CPLX2, EIF4E3, MEF2D, TLX3, ST8SIA1, ANG and CHRM3 were independent of extrinsic genomic influences in public databases. Two DMPs in NLRC5 were associated with duration of stay in Europe among migrants. All DMPs were biologically linked to migration-related factors. Conclusion: Our findings provide the first insights into DNAm differences between migrants and non-migrants.

KW - DNA methylation

KW - RODAM study

KW - migrants

KW - noncommunicable diseases

KW - sub-Saharan Africans

UR - http://www.scopus.com/inward/record.url?scp=85105139319&partnerID=8YFLogxK

U2 - 10.2217/epi-2020-0329

DO - 10.2217/epi-2020-0329

M3 - Article

C2 - 33890479

VL - 13

SP - 653

EP - 666

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 9

ER -

ID: 18157874

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