Research output: Contribution to journal › Article › Academic › peer-review
Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations. / the T2B! immunity against SARS-CoV-2 study group.
In: Journal of autoimmunity, Vol. 135, 102984, 01.02.2023.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Disease activity in patients with immune-mediated inflammatory diseases after SARS-CoV-2 vaccinations
AU - van Dam, Koos P. J.
AU - Wieske, Luuk
AU - Stalman, Eileen W.
AU - Kummer, Laura Y. L.
AU - Roosen, Jesse
AU - van Kempen, Zoé L. E.
AU - Killestein, Joep
AU - Volkers, Adriaan G.
AU - Boekel, Laura
AU - Wolbink, Gerrit J.
AU - van der Kooi, Anneke J.
AU - Raaphorst, Joost
AU - Löwenberg, Mark
AU - Takkenberg, R. Bart
AU - D'Haens, Geert R. A. M.
AU - Spuls, Phyllis I.
AU - Bekkenk, Marcel W.
AU - Musters, Annelie H.
AU - Post, Nicoline F.
AU - Bosma, Angela L.
AU - Hilhorst, Marc L.
AU - Vegting, Yosta
AU - Bemelman, Frederike J.
AU - Voskuyl, Alexandre E.
AU - Broens, Bo
AU - Sanchez, Agner Parra
AU - van Els, C. cile A. C. M.
AU - de Wit, Jelle
AU - Rutgers, Abraham
AU - de Leeuw, Karina
AU - Horváth, Barbara
AU - Verschuuren, Jan J. G. M.
AU - Ruiter, Annabel M.
AU - van Ouwerkerk, Lotte
AU - van der Woude, Diane
AU - Allaart, Renée C. F.
AU - Teng, Y. K. Onno
AU - van Paassen, Pieter
AU - Busch, Matthias H.
AU - Jallah, Papay B. P.
AU - Brusse, Esther
AU - van Doorn, Pieter A.
AU - Baars, Adája E.
AU - Hijnen, Dirk Jan
AU - Schreurs, Corine R. G.
AU - van der Pol, W. Ludo
AU - Goedee, H. Stephan
AU - Steenhuis, Maurice
AU - Keijzer, Sofie
AU - Keijser, Jim B. D.
AU - Cristianawati, Olvi
AU - Rispens, Theo
AU - Brinke, Anja ten
AU - Verstegen, Niels J. M.
AU - Marieke van Ham, S.
AU - Tas, Sander W.
AU - the T2B! immunity against SARS-CoV-2 study group
AU - Kuijpers, Taco W.
AU - Eftimov, Filip
N1 - Funding Information: We would like to thank ZonMw (The Netherlands Organization for Health Research and Development, grant 10430072010007 ) for the funding of the study and the T2B partners, including the patient groups and Health Holland for the support in this study. This collaboration project is financed by the PPP Allowance made available by Top Sector Life Sciences & Health to Samenwerkende Gezondheidsfondsen ( SGF ) under project number LSHM18055-SGF to stimulate public-private partnerships and co-financing by health foundations that are part of the SGF. Also, we would like to thank E.P. Moll van Charante, J.A Bogaards and R.A. Scholte for their guidance in the data safety monitoring board. Funding Information: This study was supported by ZonMw (The Netherlands Organization for Health Research and Development; project number 10430012010009 ). The sponsor had no role in the design, analysis or reporting of the study. Publisher Copyright: © 2022
PY - 2023/2/1
Y1 - 2023/2/1
N2 - For patients with immune-mediated inflammatory diseases (IMIDs), concerns exist about increased disease activity after vaccination. We aimed to assess changes in disease activity after SARS-CoV-2 vaccination in patients with IMIDs, and determine risk factors for increased disease activity. In this substudy of a prospective observational cohort study (Target-to-B!), we included patients with IMIDs who received a SARS-CoV-2 vaccine. Patients reported changes in disease activity on a five-point Likert scale every 60 days for up to twelve months after first vaccination. In case of self-reported increased activity, hospital records were screened whether the treating physician reported increased activity, and for potential intensification of immunosuppressive (ISP) treatment. Mixed models were used to study determinants for self-reported increased disease activity. In total, 2111 patients were included for analysis after primary immunization (mean age 49.7 years [SD 13.7], 1329/2111 (63.0%) female), from which 1266 patients for analysis after first additional vaccination. Increased disease activity at 60 days after start of primary immunization was reported by 223/2111 (10.6%). In 96/223 (43.0%) the increase was confirmed by the treating physician and in 36/223 (16.1%) ISP treatment was intensified. Increased disease activity at seven to 60 days after additional vaccination, was reported by 139/1266 (11.0%). Vaccinations were not temporally associated with self-reported increased disease activity. Conversely, increased disease activity before first vaccination, neuromuscular disease, and multiple sclerosis were associated. Altogether, self-reported increased disease activity after vaccination against SARS-CoV-2 was recorded in a minority of patients and was generally mild. Moreover, multivariate analyses suggest that disease related factors, but not vaccinations are the major determinants for self-reported increased disease activity.
AB - For patients with immune-mediated inflammatory diseases (IMIDs), concerns exist about increased disease activity after vaccination. We aimed to assess changes in disease activity after SARS-CoV-2 vaccination in patients with IMIDs, and determine risk factors for increased disease activity. In this substudy of a prospective observational cohort study (Target-to-B!), we included patients with IMIDs who received a SARS-CoV-2 vaccine. Patients reported changes in disease activity on a five-point Likert scale every 60 days for up to twelve months after first vaccination. In case of self-reported increased activity, hospital records were screened whether the treating physician reported increased activity, and for potential intensification of immunosuppressive (ISP) treatment. Mixed models were used to study determinants for self-reported increased disease activity. In total, 2111 patients were included for analysis after primary immunization (mean age 49.7 years [SD 13.7], 1329/2111 (63.0%) female), from which 1266 patients for analysis after first additional vaccination. Increased disease activity at 60 days after start of primary immunization was reported by 223/2111 (10.6%). In 96/223 (43.0%) the increase was confirmed by the treating physician and in 36/223 (16.1%) ISP treatment was intensified. Increased disease activity at seven to 60 days after additional vaccination, was reported by 139/1266 (11.0%). Vaccinations were not temporally associated with self-reported increased disease activity. Conversely, increased disease activity before first vaccination, neuromuscular disease, and multiple sclerosis were associated. Altogether, self-reported increased disease activity after vaccination against SARS-CoV-2 was recorded in a minority of patients and was generally mild. Moreover, multivariate analyses suggest that disease related factors, but not vaccinations are the major determinants for self-reported increased disease activity.
KW - Autoimmune disease
KW - COVID-19
KW - Disease activity
KW - Flare
KW - SARS-CoV-2
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=85145851522&partnerID=8YFLogxK
U2 - 10.1016/j.jaut.2022.102984
DO - 10.1016/j.jaut.2022.102984
M3 - Article
C2 - 36621174
VL - 135
JO - Journal of autoimmunity
JF - Journal of autoimmunity
SN - 0896-8411
M1 - 102984
ER -
ID: 30840554