Standard

Dim light at night disturbs the daily sleep-wake cycle in the rat. / Stenvers, Dirk Jan; van Dorp, Rick; Foppen, Ewout et al.

In: Scientific reports, Vol. 6, 2016, p. 35662.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Stenvers, DJ, van Dorp, R, Foppen, E, Mendoza, J, Opperhuizen, A-L, Fliers, E, Bisschop, PH, Meijer, JH, Kalsbeek, A & Deboer, T 2016, 'Dim light at night disturbs the daily sleep-wake cycle in the rat', Scientific reports, vol. 6, pp. 35662. https://doi.org/10.1038/srep35662

APA

Stenvers, D. J., van Dorp, R., Foppen, E., Mendoza, J., Opperhuizen, A-L., Fliers, E., Bisschop, P. H., Meijer, J. H., Kalsbeek, A., & Deboer, T. (2016). Dim light at night disturbs the daily sleep-wake cycle in the rat. Scientific reports, 6, 35662. https://doi.org/10.1038/srep35662

Vancouver

Stenvers DJ, van Dorp R, Foppen E, Mendoza J, Opperhuizen A-L, Fliers E et al. Dim light at night disturbs the daily sleep-wake cycle in the rat. Scientific reports. 2016;6:35662. doi: 10.1038/srep35662

Author

Stenvers, Dirk Jan ; van Dorp, Rick ; Foppen, Ewout et al. / Dim light at night disturbs the daily sleep-wake cycle in the rat. In: Scientific reports. 2016 ; Vol. 6. pp. 35662.

BibTeX

@article{22254e64ea81468eaf5115275996ec4a,
title = "Dim light at night disturbs the daily sleep-wake cycle in the rat",
abstract = "Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats to either a 12 h light (150-200lux):12 h dark (LD) schedule or a 12 h light (150-200 lux):12 h dim white light (5 lux) (LDim) schedule. LDim acutely decreased the amplitude of daily rhythms of REM and NREM sleep, with a further decrease over the following days. LDim diminished the rhythms of 1) the circadian 16-19 Hz frequency domain within the NREM sleep EEG, and 2) SCN clock gene expression. LDim also induced internal desynchronization in locomotor activity by introducing a free running rhythm with a period of similar to 25 h next to the entrained 24 h rhythm. LDim did not affect body weight or glucose tolerance. In conclusion, we introduce the first rodent model for disturbed circadian control of sleep due to LAN. We show that internal desynchronization is possible in a 24 h L:D cycle which suggests that a similar desynchronization may explain the association between LAN and human insomnia",
author = "Stenvers, {Dirk Jan} and {van Dorp}, Rick and Ewout Foppen and Jorge Mendoza and Anne-Loes Opperhuizen and Eric Fliers and Bisschop, {Peter H.} and Meijer, {Johanna H.} and Andries Kalsbeek and Tom Deboer",
year = "2016",
doi = "10.1038/srep35662",
language = "English",
volume = "6",
pages = "35662",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Dim light at night disturbs the daily sleep-wake cycle in the rat

AU - Stenvers, Dirk Jan

AU - van Dorp, Rick

AU - Foppen, Ewout

AU - Mendoza, Jorge

AU - Opperhuizen, Anne-Loes

AU - Fliers, Eric

AU - Bisschop, Peter H.

AU - Meijer, Johanna H.

AU - Kalsbeek, Andries

AU - Deboer, Tom

PY - 2016

Y1 - 2016

N2 - Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats to either a 12 h light (150-200lux):12 h dark (LD) schedule or a 12 h light (150-200 lux):12 h dim white light (5 lux) (LDim) schedule. LDim acutely decreased the amplitude of daily rhythms of REM and NREM sleep, with a further decrease over the following days. LDim diminished the rhythms of 1) the circadian 16-19 Hz frequency domain within the NREM sleep EEG, and 2) SCN clock gene expression. LDim also induced internal desynchronization in locomotor activity by introducing a free running rhythm with a period of similar to 25 h next to the entrained 24 h rhythm. LDim did not affect body weight or glucose tolerance. In conclusion, we introduce the first rodent model for disturbed circadian control of sleep due to LAN. We show that internal desynchronization is possible in a 24 h L:D cycle which suggests that a similar desynchronization may explain the association between LAN and human insomnia

AB - Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats to either a 12 h light (150-200lux):12 h dark (LD) schedule or a 12 h light (150-200 lux):12 h dim white light (5 lux) (LDim) schedule. LDim acutely decreased the amplitude of daily rhythms of REM and NREM sleep, with a further decrease over the following days. LDim diminished the rhythms of 1) the circadian 16-19 Hz frequency domain within the NREM sleep EEG, and 2) SCN clock gene expression. LDim also induced internal desynchronization in locomotor activity by introducing a free running rhythm with a period of similar to 25 h next to the entrained 24 h rhythm. LDim did not affect body weight or glucose tolerance. In conclusion, we introduce the first rodent model for disturbed circadian control of sleep due to LAN. We show that internal desynchronization is possible in a 24 h L:D cycle which suggests that a similar desynchronization may explain the association between LAN and human insomnia

U2 - 10.1038/srep35662

DO - 10.1038/srep35662

M3 - Article

C2 - 27762290

VL - 6

SP - 35662

JO - Scientific reports

JF - Scientific reports

SN - 2045-2322

ER -

ID: 3004214