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Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus. / Bot, Maarten; Schuurman, P. Richard; Odekerken, Vincent J. J. et al.

In: Journal of neurology, neurosurgery, and psychiatry, Vol. 89, 2018, p. 493-498.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

Bot, M, Schuurman, PR, Odekerken, VJJ, Verhagen, R, Contarino, FM, de Bie, RMA & van den Munckhof, P 2018, 'Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus', Journal of neurology, neurosurgery, and psychiatry, vol. 89, pp. 493-498. https://doi.org/10.1136/jnnp-2017-316907

APA

Bot, M., Schuurman, P. R., Odekerken, V. J. J., Verhagen, R., Contarino, F. M., de Bie, R. M. A., & van den Munckhof, P. (2018). Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus. Journal of neurology, neurosurgery, and psychiatry, 89, 493-498. https://doi.org/10.1136/jnnp-2017-316907

Vancouver

Bot M, Schuurman PR, Odekerken VJJ, Verhagen R, Contarino FM, de Bie RMA et al. Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus. Journal of neurology, neurosurgery, and psychiatry. 2018;89:493-498. doi: 10.1136/jnnp-2017-316907

Author

Bot, Maarten ; Schuurman, P. Richard ; Odekerken, Vincent J. J. et al. / Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus. In: Journal of neurology, neurosurgery, and psychiatry. 2018 ; Vol. 89. pp. 493-498.

BibTeX

@article{f40778d911c24bf79188107551b96ec2,
title = "Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus",
abstract = "Individual motor improvement after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) varies considerably. Stereotactic targeting of the dorsolateral sensorimotor part of the STN is considered paramount for maximising effectiveness, but studies employing the midcommissural point (MCP) as anatomical reference failed to show correlation between DBS location and motor improvement. The medial border of the STN as reference may provide better insight in the relationship between DBS location and clinical outcome. Motor improvement after 12 months of 65 STN DBS electrodes was categorised into non-responding, responding and optimally responding body-sides. Stereotactic coordinates of optimal electrode contacts relative to both medial STN border and MCP served to define theoretic DBS 'hotspots'. Using the medial STN border as reference, significant negative correlation (Pearson's correlation -0.52, P <0.01) was found between the Euclidean distance from the centre of stimulation to this DBS hotspot and motor improvement. This hotspot was located at 2.8 mm lateral, 1.7 mm anterior and 2.5 mm superior relative to the medial STN border. Using MCP as reference, no correlation was found. The medial STN border proved superior compared with MCP as anatomical reference for correlation of DBS location and motor improvement, and enabled defining an optimal DBS location within the nucleus. We therefore propose the medial STN border as a better individual reference point than the currently used MCP on preoperative stereotactic imaging, in order to obtain optimal and thus less variable motor improvement for individual patients with PD following STN DBS",
author = "Maarten Bot and Schuurman, {P. Richard} and Odekerken, {Vincent J. J.} and Rens Verhagen and Contarino, {Fiorella Maria} and {de Bie}, {Rob M. A.} and {van den Munckhof}, Pepijn",
year = "2018",
doi = "10.1136/jnnp-2017-316907",
language = "English",
volume = "89",
pages = "493--498",
journal = "Journal of neurology, neurosurgery, and psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",

}

RIS

TY - JOUR

T1 - Deep brain stimulation for Parkinson's disease: defining the optimal location within the subthalamic nucleus

AU - Bot, Maarten

AU - Schuurman, P. Richard

AU - Odekerken, Vincent J. J.

AU - Verhagen, Rens

AU - Contarino, Fiorella Maria

AU - de Bie, Rob M. A.

AU - van den Munckhof, Pepijn

PY - 2018

Y1 - 2018

N2 - Individual motor improvement after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) varies considerably. Stereotactic targeting of the dorsolateral sensorimotor part of the STN is considered paramount for maximising effectiveness, but studies employing the midcommissural point (MCP) as anatomical reference failed to show correlation between DBS location and motor improvement. The medial border of the STN as reference may provide better insight in the relationship between DBS location and clinical outcome. Motor improvement after 12 months of 65 STN DBS electrodes was categorised into non-responding, responding and optimally responding body-sides. Stereotactic coordinates of optimal electrode contacts relative to both medial STN border and MCP served to define theoretic DBS 'hotspots'. Using the medial STN border as reference, significant negative correlation (Pearson's correlation -0.52, P <0.01) was found between the Euclidean distance from the centre of stimulation to this DBS hotspot and motor improvement. This hotspot was located at 2.8 mm lateral, 1.7 mm anterior and 2.5 mm superior relative to the medial STN border. Using MCP as reference, no correlation was found. The medial STN border proved superior compared with MCP as anatomical reference for correlation of DBS location and motor improvement, and enabled defining an optimal DBS location within the nucleus. We therefore propose the medial STN border as a better individual reference point than the currently used MCP on preoperative stereotactic imaging, in order to obtain optimal and thus less variable motor improvement for individual patients with PD following STN DBS

AB - Individual motor improvement after deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) varies considerably. Stereotactic targeting of the dorsolateral sensorimotor part of the STN is considered paramount for maximising effectiveness, but studies employing the midcommissural point (MCP) as anatomical reference failed to show correlation between DBS location and motor improvement. The medial border of the STN as reference may provide better insight in the relationship between DBS location and clinical outcome. Motor improvement after 12 months of 65 STN DBS electrodes was categorised into non-responding, responding and optimally responding body-sides. Stereotactic coordinates of optimal electrode contacts relative to both medial STN border and MCP served to define theoretic DBS 'hotspots'. Using the medial STN border as reference, significant negative correlation (Pearson's correlation -0.52, P <0.01) was found between the Euclidean distance from the centre of stimulation to this DBS hotspot and motor improvement. This hotspot was located at 2.8 mm lateral, 1.7 mm anterior and 2.5 mm superior relative to the medial STN border. Using MCP as reference, no correlation was found. The medial STN border proved superior compared with MCP as anatomical reference for correlation of DBS location and motor improvement, and enabled defining an optimal DBS location within the nucleus. We therefore propose the medial STN border as a better individual reference point than the currently used MCP on preoperative stereotactic imaging, in order to obtain optimal and thus less variable motor improvement for individual patients with PD following STN DBS

U2 - 10.1136/jnnp-2017-316907

DO - 10.1136/jnnp-2017-316907

M3 - Article

C2 - 29353236

VL - 89

SP - 493

EP - 498

JO - Journal of neurology, neurosurgery, and psychiatry

JF - Journal of neurology, neurosurgery, and psychiatry

SN - 0022-3050

ER -

ID: 4548421