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Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods. / Hofstee, Marloes I.; Muthukrishnan, Gowrishankar; Atkins, Gerald J. et al.

In: American journal of pathology, Vol. 190, No. 6, 01.06.2020, p. 1151-1163.

Research output: Contribution to journal › Review article › Academic › peer-review

Harvard

Hofstee, MI, Muthukrishnan, G, Atkins, GJ, Riool, M, Thompson, K, Morgenstern, M, Stoddart, MJ, Richards, RG, Zaat, SAJ & Moriarty, TF 2020, 'Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods', American journal of pathology, vol. 190, no. 6, pp. 1151-1163. https://doi.org/10.1016/j.ajpath.2020.02.007

APA

Hofstee, M. I., Muthukrishnan, G., Atkins, G. J., Riool, M., Thompson, K., Morgenstern, M., Stoddart, M. J., Richards, R. G., Zaat, S. A. J., & Moriarty, T. F. (2020). Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods. American journal of pathology, 190(6), 1151-1163. https://doi.org/10.1016/j.ajpath.2020.02.007

Vancouver

Hofstee MI, Muthukrishnan G, Atkins GJ, Riool M, Thompson K, Morgenstern M et al. Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods. American journal of pathology. 2020 Jun 1;190(6):1151-1163. doi: 10.1016/j.ajpath.2020.02.007

Author

Hofstee, Marloes I. ; Muthukrishnan, Gowrishankar ; Atkins, Gerald J. et al. / Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods. In: American journal of pathology. 2020 ; Vol. 190, No. 6. pp. 1151-1163.

BibTeX

@article{2eb45b08d47f44ad80a837eb4c29a8d8,
title = "Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods",
abstract = "Osteomyelitis is an inflammation of the bone and bone marrow that is most commonly caused by a Staphylococcus aureus infection. Much of our understanding of the underlying pathophysiology of osteomyelitis, from the perspective of both host and pathogen, has been revised in recent years, with notable discoveries including the role played by osteocytes in the recruitment of immune cells, the invasion and persistence of S. aureus in submicron channels of cortical bone, and the diagnostic role of polymorphonuclear cells in implant-associated osteomyelitis. Advanced in vitro cell culture models, such as ex vivo culture models or organoids, have also been developed over the past decade, and have become widespread in many fields, including infectious diseases. These models better mimic the in vivo environment, allow the use of human cells, and can reduce our reliance on animals in osteomyelitis research. In this review, we provide an overview of the main pathologic concepts in osteomyelitis, with a focus on the new discoveries in recent years. Furthermore, we outline the value of modern in vitro cell culture techniques, with a focus on their current application to infectious diseases and osteomyelitis in particular.",
author = "Hofstee, {Marloes I.} and Gowrishankar Muthukrishnan and Atkins, {Gerald J.} and Martijn Riool and Keith Thompson and Mario Morgenstern and Stoddart, {Martin J.} and Richards, {Robert G.} and Zaat, {Sebastian A. J.} and Moriarty, {Thomas F.}",
year = "2020",
month = jun,
day = "1",
doi = "10.1016/j.ajpath.2020.02.007",
language = "English",
volume = "190",
pages = "1151--1163",
journal = "American journal of pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Current Concepts of Osteomyelitis: From Pathologic Mechanisms to Advanced Research Methods

AU - Hofstee, Marloes I.

AU - Muthukrishnan, Gowrishankar

AU - Atkins, Gerald J.

AU - Riool, Martijn

AU - Thompson, Keith

AU - Morgenstern, Mario

AU - Stoddart, Martin J.

AU - Richards, Robert G.

AU - Zaat, Sebastian A. J.

AU - Moriarty, Thomas F.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Osteomyelitis is an inflammation of the bone and bone marrow that is most commonly caused by a Staphylococcus aureus infection. Much of our understanding of the underlying pathophysiology of osteomyelitis, from the perspective of both host and pathogen, has been revised in recent years, with notable discoveries including the role played by osteocytes in the recruitment of immune cells, the invasion and persistence of S. aureus in submicron channels of cortical bone, and the diagnostic role of polymorphonuclear cells in implant-associated osteomyelitis. Advanced in vitro cell culture models, such as ex vivo culture models or organoids, have also been developed over the past decade, and have become widespread in many fields, including infectious diseases. These models better mimic the in vivo environment, allow the use of human cells, and can reduce our reliance on animals in osteomyelitis research. In this review, we provide an overview of the main pathologic concepts in osteomyelitis, with a focus on the new discoveries in recent years. Furthermore, we outline the value of modern in vitro cell culture techniques, with a focus on their current application to infectious diseases and osteomyelitis in particular.

AB - Osteomyelitis is an inflammation of the bone and bone marrow that is most commonly caused by a Staphylococcus aureus infection. Much of our understanding of the underlying pathophysiology of osteomyelitis, from the perspective of both host and pathogen, has been revised in recent years, with notable discoveries including the role played by osteocytes in the recruitment of immune cells, the invasion and persistence of S. aureus in submicron channels of cortical bone, and the diagnostic role of polymorphonuclear cells in implant-associated osteomyelitis. Advanced in vitro cell culture models, such as ex vivo culture models or organoids, have also been developed over the past decade, and have become widespread in many fields, including infectious diseases. These models better mimic the in vivo environment, allow the use of human cells, and can reduce our reliance on animals in osteomyelitis research. In this review, we provide an overview of the main pathologic concepts in osteomyelitis, with a focus on the new discoveries in recent years. Furthermore, we outline the value of modern in vitro cell culture techniques, with a focus on their current application to infectious diseases and osteomyelitis in particular.

UR - http://www.scopus.com/inward/record.url?scp=85085038648&partnerID=8YFLogxK

U2 - 10.1016/j.ajpath.2020.02.007

DO - 10.1016/j.ajpath.2020.02.007

M3 - Review article

C2 - 32194053

VL - 190

SP - 1151

EP - 1163

JO - American journal of pathology

JF - American journal of pathology

SN - 0002-9440

IS - 6

ER -

ID: 11683240