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C-type lectin receptors in the control of T helper cell differentiation. / Geijtenbeek, Teunis B. H.; Gringhuis, Sonja I.

In: Nature reviews. Immunology, Vol. 16, No. 7, 2016, p. 433-448.

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@article{bfc34e487b6242fbaf7f82532d12a19d,
title = "C-type lectin receptors in the control of T helper cell differentiation",
abstract = "Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with other receptors, such as other CLRs, Toll-like receptors and interferon receptors, to induce signalling pathways that trigger specialized cytokine programmes for polarization of TH cell differentiation. In this Review, we discuss how triggering of the prototypical CLRs leads to distinct pathogen-tailored TH cell responses and how we can harness our expanding knowledge for vaccine design and the treatment of inflammatory and malignant diseases",
author = "Geijtenbeek, {Teunis B. H.} and Gringhuis, {Sonja I.}",
year = "2016",
doi = "10.1038/nri.2016.55",
language = "English",
volume = "16",
pages = "433--448",
journal = "Nature reviews. Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - C-type lectin receptors in the control of T helper cell differentiation

AU - Geijtenbeek, Teunis B. H.

AU - Gringhuis, Sonja I.

PY - 2016

Y1 - 2016

N2 - Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with other receptors, such as other CLRs, Toll-like receptors and interferon receptors, to induce signalling pathways that trigger specialized cytokine programmes for polarization of TH cell differentiation. In this Review, we discuss how triggering of the prototypical CLRs leads to distinct pathogen-tailored TH cell responses and how we can harness our expanding knowledge for vaccine design and the treatment of inflammatory and malignant diseases

AB - Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with other receptors, such as other CLRs, Toll-like receptors and interferon receptors, to induce signalling pathways that trigger specialized cytokine programmes for polarization of TH cell differentiation. In this Review, we discuss how triggering of the prototypical CLRs leads to distinct pathogen-tailored TH cell responses and how we can harness our expanding knowledge for vaccine design and the treatment of inflammatory and malignant diseases

U2 - 10.1038/nri.2016.55

DO - 10.1038/nri.2016.55

M3 - Review article

C2 - 27291962

VL - 16

SP - 433

EP - 448

JO - Nature reviews. Immunology

JF - Nature reviews. Immunology

SN - 1474-1733

IS - 7

ER -

ID: 2929574