Research output: Contribution to journal › Review article › Academic › peer-review
Control of cytokine production by human Fc gamma receptors: implications for pathogen defense and autoimmunity. / Vogelpoel, Lisa T. C.; Baeten, Dominique L. P.; de Jong, Esther C. et al.
In: Frontiers in immunology, Vol. 6, 2015, p. 79.Research output: Contribution to journal › Review article › Academic › peer-review
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TY - JOUR
T1 - Control of cytokine production by human Fc gamma receptors: implications for pathogen defense and autoimmunity
AU - Vogelpoel, Lisa T. C.
AU - Baeten, Dominique L. P.
AU - de Jong, Esther C.
AU - den Dunnen, Jeroen
PY - 2015
Y1 - 2015
N2 - Control of cytokine production by immune cells is pivotal for counteracting infections via orchestration of local and systemic inflammation. Although their contribution has long been underexposed, it has recently become clear that human Fc gamma receptors (Fc gamma Rs), which are receptors for the Fc region of immunoglobulin G (IgG) antibodies, play a critical role in this process by controlling tissue- and pathogen-specific cytokine production. Whereas individual stimulation of Fc gamma Rs does not evoke cytokine production, Fc gamma Rs cell-type specifically interact with various other receptors for selective amplification or inhibition of particular cytokines, thereby tailoring cytokine responses to the immunological context. The physiological function of Fc gamma R-mediated control of cytokine production is to counteract infections with various classes of pathogens. Upon IgG opsonization, pathogens are simultaneously recognized by Fc gamma Rs as well as by various pathogen-sensing receptors, leading to the induction of pathogen class-specific immune responses. However, when erroneously activated, the same mechanism also contributes to the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In this review, we discuss control of cytokine production as a novel function of Fc gamma Rs in human innate immune cells in the context of homeostasis, infection, and autoimmunity and address the possibilities for future therapeutic exploitation
AB - Control of cytokine production by immune cells is pivotal for counteracting infections via orchestration of local and systemic inflammation. Although their contribution has long been underexposed, it has recently become clear that human Fc gamma receptors (Fc gamma Rs), which are receptors for the Fc region of immunoglobulin G (IgG) antibodies, play a critical role in this process by controlling tissue- and pathogen-specific cytokine production. Whereas individual stimulation of Fc gamma Rs does not evoke cytokine production, Fc gamma Rs cell-type specifically interact with various other receptors for selective amplification or inhibition of particular cytokines, thereby tailoring cytokine responses to the immunological context. The physiological function of Fc gamma R-mediated control of cytokine production is to counteract infections with various classes of pathogens. Upon IgG opsonization, pathogens are simultaneously recognized by Fc gamma Rs as well as by various pathogen-sensing receptors, leading to the induction of pathogen class-specific immune responses. However, when erroneously activated, the same mechanism also contributes to the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In this review, we discuss control of cytokine production as a novel function of Fc gamma Rs in human innate immune cells in the context of homeostasis, infection, and autoimmunity and address the possibilities for future therapeutic exploitation
U2 - 10.3389/fimmu.2015.00079
DO - 10.3389/fimmu.2015.00079
M3 - Review article
C2 - 25759693
VL - 6
SP - 79
JO - Frontiers in immunology
JF - Frontiers in immunology
SN - 1664-3224
ER -
ID: 2586143