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Computed tomographic airway morphology after targeted lung denervation treatment in COPD. / AIRFLOW-2 Study Group.
In: Respiratory medicine, Vol. 206, 107059, 01.01.2023.

Research output: Contribution to journal › Article › Academic › peer-review

Harvard

AIRFLOW-2 Study Group 2023, 'Computed tomographic airway morphology after targeted lung denervation treatment in COPD', Respiratory medicine, vol. 206, 107059. https://doi.org/10.1016/j.rmed.2022.107059

APA

AIRFLOW-2 Study Group (2023). Computed tomographic airway morphology after targeted lung denervation treatment in COPD. Respiratory medicine, 206, [107059]. https://doi.org/10.1016/j.rmed.2022.107059

Vancouver

AIRFLOW-2 Study Group. Computed tomographic airway morphology after targeted lung denervation treatment in COPD. Respiratory medicine. 2023 Jan 1;206:107059. doi: 10.1016/j.rmed.2022.107059

Author

AIRFLOW-2 Study Group. / Computed tomographic airway morphology after targeted lung denervation treatment in COPD. In: Respiratory medicine. 2023 ; Vol. 206.

BibTeX

@article{0e1c1fbaa3294a0c927f2be6530895d6,
title = "Computed tomographic airway morphology after targeted lung denervation treatment in COPD",
abstract = "This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV1. Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes.",
author = "Hartman, {Jorine E.} and Herth, {Felix J. F.} and Pallav Shah and {AIRFLOW-2 Study Group} and Christophe Pison and Arschang Valipour and Dirk-Jan Slebos and Christine Abele and Irene Firlinger and Kiran Kothakuzhakal and Marina Duller and Bernd Lamprecht and Roland Kropfmueller and Kornelia Holzmann and Sandra Rathmeier and Ralf Hubner and Leonore Erdmann and Bettina Temmesfeld-Wollbr{\"u}ck and {Ruwwe Gl{\"o}senkamp}, Christoph and Wolfgang Gesierich and Frank Reichenberger and Christa Niehaus and Felix Herth and Ralf Eberhardt and Daniela Gompelmann and Brigitte Rump and Kaid Darwiche and Stephan Eisenmann and Ulrike Kaiser and Birte Schwarz and Ulrike Sampel and Christian Schumann and Robert Kaiser and Kathryn Schumann-Stoiber and Dirk Skowasch and Sabine Ring and Amandine Briault and Francois Arbib and Marie Jondot and Thierry Perez and Clement Fournier and Regis Matran and Michele Catto and Nathalie Bautin and {de Broucker}, Virginie and Marie Willemin and Anne Prevotat and Ludivine Wemeau and Alice Gicquello and Morgane Foulon and Hasna Camara and Gaetan Deslee and Herve Vallerand and Sandra Dury and Delphine Gras and Margaux Bonnaire-Verdier and Romain Kessler and Sandrine Hirschi and Michele Porzio and Tristan Degot and Mathieu Canuet and Armelle Schuller and Julien Stauder and Azouaou, {Sahra Ali} and Armelle Marceau and Herv{\'e} Mal and Yolande Costa and Shah, {Pallav L.} and Justin Garner and Karthi Srikanthan and Cielito Caneja and John Thornton and Hacken, {Nick Ten} and Jorine Hartman and Karin Klooster and Sonja Augustijn and Peter Bonta and Jouke Annema and {van de Pol}, Marianne and Annika Goorsenberg",
note = "Funding Information: The AIRFLOW-2 trial was funded by Nuvaira Inc, Minneapolis, MN, USA . The funding source had no involvement in this analysis or in the writing of this manuscript. Funding Information: The AIRFLOW-2 trial was funded by Nuvaira Inc, Minneapolis, MN, USA. The funding source had no involvement in this analysis or in the writing of this manuscript.We would like to thank the Dutch Foundation for Asthma Prevention (Noorderlijke CARA stichting) for the grant we received which allowed us to purchase the software used for this analysis. Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2023",
month = jan,
day = "1",
doi = "10.1016/j.rmed.2022.107059",
language = "English",
volume = "206",
journal = "Respiratory medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",

}

RIS

TY - JOUR

T1 - Computed tomographic airway morphology after targeted lung denervation treatment in COPD

AU - Hartman, Jorine E.

AU - Herth, Felix J. F.

AU - Shah, Pallav

AU - AIRFLOW-2 Study Group

AU - Pison, Christophe

AU - Valipour, Arschang

AU - Slebos, Dirk-Jan

AU - Abele, Christine

AU - Firlinger, Irene

AU - Kothakuzhakal, Kiran

AU - Duller, Marina

AU - Lamprecht, Bernd

AU - Kropfmueller, Roland

AU - Holzmann, Kornelia

AU - Rathmeier, Sandra

AU - Hubner, Ralf

AU - Erdmann, Leonore

AU - Temmesfeld-Wollbrück, Bettina

AU - Ruwwe Glösenkamp, Christoph

AU - Gesierich, Wolfgang

AU - Reichenberger, Frank

AU - Niehaus, Christa

AU - Herth, Felix

AU - Eberhardt, Ralf

AU - Gompelmann, Daniela

AU - Rump, Brigitte

AU - Darwiche, Kaid

AU - Eisenmann, Stephan

AU - Kaiser, Ulrike

AU - Schwarz, Birte

AU - Sampel, Ulrike

AU - Schumann, Christian

AU - Kaiser, Robert

AU - Schumann-Stoiber, Kathryn

AU - Skowasch, Dirk

AU - Ring, Sabine

AU - Briault, Amandine

AU - Arbib, Francois

AU - Jondot, Marie

AU - Perez, Thierry

AU - Fournier, Clement

AU - Matran, Regis

AU - Catto, Michele

AU - Bautin, Nathalie

AU - de Broucker, Virginie

AU - Willemin, Marie

AU - Prevotat, Anne

AU - Wemeau, Ludivine

AU - Gicquello, Alice

AU - Foulon, Morgane

AU - Camara, Hasna

AU - Deslee, Gaetan

AU - Vallerand, Herve

AU - Dury, Sandra

AU - Gras, Delphine

AU - Bonnaire-Verdier, Margaux

AU - Kessler, Romain

AU - Hirschi, Sandrine

AU - Porzio, Michele

AU - Degot, Tristan

AU - Canuet, Mathieu

AU - Schuller, Armelle

AU - Stauder, Julien

AU - Azouaou, Sahra Ali

AU - Marceau, Armelle

AU - Mal, Hervé

AU - Costa, Yolande

AU - Shah, Pallav L.

AU - Garner, Justin

AU - Srikanthan, Karthi

AU - Caneja, Cielito

AU - Thornton, John

AU - Hacken, Nick Ten

AU - Hartman, Jorine

AU - Klooster, Karin

AU - Augustijn, Sonja

AU - Bonta, Peter

AU - Annema, Jouke

AU - van de Pol, Marianne

AU - Goorsenberg, Annika

N1 - Funding Information: The AIRFLOW-2 trial was funded by Nuvaira Inc, Minneapolis, MN, USA . The funding source had no involvement in this analysis or in the writing of this manuscript. Funding Information: The AIRFLOW-2 trial was funded by Nuvaira Inc, Minneapolis, MN, USA. The funding source had no involvement in this analysis or in the writing of this manuscript.We would like to thank the Dutch Foundation for Asthma Prevention (Noorderlijke CARA stichting) for the grant we received which allowed us to purchase the software used for this analysis. Publisher Copyright: © 2022 The Author(s)

PY - 2023/1/1

Y1 - 2023/1/1

N2 - This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV1. Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes.

AB - This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV1. Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85142827916&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2022.107059

DO - 10.1016/j.rmed.2022.107059

M3 - Article

C2 - 36459953

VL - 206

JO - Respiratory medicine

JF - Respiratory medicine

SN - 0954-6111

M1 - 107059

ER -

ID: 28415984